Role of adiponectin in gestational diabetes mellitus: advances in mechanistic insights and early predictive potential [0.03%]
脂联素在妊娠糖尿病中的作用：机制见解和早期预测潜力的新进展
Yuting Chen,Feiming He,Lili Zhang et al.
Yuting Chen et al.
Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy and is associated with an increased risk of short-term adverse maternal and neonatal outcomes, as well as long-term metabolic disorders in both mothers and ...
Depot-specific differences in visceral and subcutaneous adipose tissue from patients with obesity [0.03%]
肥胖患者的肠系膜和皮下脂肪组织的部位特异性差异
Mathis Neuhaus,Claes Fryklund,Min Cai et al.
Mathis Neuhaus et al.
Factors limiting fat cell expandability remain scarcely explored, and comprehensive functional comparisons of adipose depots in humans are limited. In the present study, we collected visceral adipose tissue (VAT) and subcutaneous adipose ti...
β2-adrenergic receptor stimulation drives differentiation of human adipose-derived mesenchymal stem cells into beige adipocytes [0.03%]
β2-肾上腺素受体刺激驱动人脂肪源性间充质干细胞向米色脂肪细胞分化
Kazuki Maekawa,Fumika Yokoyama,Rie Tsutsumi et al.
Kazuki Maekawa et al.
β-Adrenergic receptors (β-ARs) drive the induction of beige adipocytes in rodents and humans, yet the dominant human subtype, β2-AR or β3-AR, remains debated. This study aimed to confirm whether human adipose-derived mesenchymal stem ce...
When LXA4 meets white fat: browning via the miR-133a-3p/SIRT1 pathway in mouse models [0.03%]
LXA4通过miR-133a-3p/SIRT1信号通路诱导白色脂肪棕色化及其机制研究
Dan Yu,Yuan Ruan,Yisu Wang et al.
Dan Yu et al.
Given the established positive role of Lipoxin A4 (LXA4) in adipose browning at the cellular level, this study investigated its possible effect on white fat browning and the underlying molecular mechanisms. The obese insulin resistance mous...
Twf1 regulates adipocyte proliferation and differentiation through Yap nucleus accumulation [0.03%]
Twf1通过Yap核积累调节脂肪细胞增殖和分化
Chen Kai,Haiyan Xu,Suzhen Lv et al.
Chen Kai et al.
Obesity involves white adipose tissue (WAT) expansion via hyperplasia and hypertrophy. Impaired adipocyte proliferation leads to pathological hypertrophy, inflammation and metabolic dysfunction. Aberrant F‑actin turnover disrupts prolifera...
Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone [0.03%]
前列腺PI-RADS和PSA双灰区患者的前列腺穿刺结果相关影像学标记：前列腺周脂肪厚度标准化测量
Tianyu Xiong,Liting Shen,Yunpeng Fan et al.
Tianyu Xiong et al.
Periprostatic adipose tissue (PPAT) is a potential factor closely associated with prostate cancer (PCa) development. This study aimed to introduce normalized PPAT thickness, a novel imaging biomarker, as a PCa predictor for patients within ...
Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells [0.03%]
多组学整合揭示了小鼠胚胎干细胞向脂肪细胞分化过程中趋同的细胞外基质重塑和脂质代谢重编程是类脂肪细胞分化的中心轴线
M Al-Sayegh,M Khalili,M Alzaabi et al.
M Al-Sayegh et al.
Adipogenesis from mouse embryonic stem cells (mESCs) offers a tractable model for dissecting early adipocyte commitment, yet the mechanisms coordinating this transition across multiple biological layers remain incompletely understood. Here ...
Lin-Fei He,Zhi-Mei Liao,Jun-Ling Chen et al.
Lin-Fei He et al.
Visceral fat has weaker beige adipogenesis than subcutaneous fat with unclear mechanisms. The Wilms tumour gene (Wt1), a visceral adipocyte marker, is highly expressed in visceral adipose tissue (VAT) and visceral adipose-derived stem cells...
A non-invasive method for light-inducible knockout across all cell types in mouse subcutaneous adipose tissue [0.03%]
一种在小鼠皮下脂肪组织所有细胞类型中进行光诱导敲除的非侵入性方法
Erica de Sousa,Magdalena Blaszkiewicz,Kristy Townsend
Erica de Sousa
Cre recombination is a widely used technique for mechanistic insights in physiology and disease. However, available constitutive and inducible Cre systems present challenges that can be prohibitive for some study designs. For example, Cre e...
mTORC2 regulates lipid metabolism-driven TAMs via the PPAR-γ/CD36 pathway to promote liposarcoma progression [0.03%]
mTORC2通过PPAR-γ/CD36通路调节脂代谢驱动的巨噬细胞促进脂肪肉瘤进展
Weihua Xiao,Jingdan Sheng,Chunjiao Liu et al.
Weihua Xiao et al.
Tumour-associated macrophages (TAMs) exert a pivotal function in tumour progression, and M2-type TAMs are closely linked to tumour-promoting functions. Mechanistic target of rapamycin complex 2 (mTORC2) may mediate TAM polarization and subs...