Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone [0.03%]
前列腺PI-RADS和PSA双灰区患者的前列腺穿刺结果相关影像学标记：前列腺周脂肪厚度标准化测量
Tianyu Xiong,Liting Shen,Yunpeng Fan et al.
Tianyu Xiong et al.
Periprostatic adipose tissue (PPAT) is a potential factor closely associated with prostate cancer (PCa) development. This study aimed to introduce normalized PPAT thickness, a novel imaging biomarker, as a PCa predictor for patients within ...
Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells [0.03%]
多组学整合揭示了小鼠胚胎干细胞向脂肪细胞分化过程中趋同的细胞外基质重塑和脂质代谢重编程是类脂肪细胞分化的中心轴线
M Al-Sayegh,M Khalili,M Alzaabi et al.
M Al-Sayegh et al.
Adipogenesis from mouse embryonic stem cells (mESCs) offers a tractable model for dissecting early adipocyte commitment, yet the mechanisms coordinating this transition across multiple biological layers remain incompletely understood. Here ...
Lin-Fei He,Zhi-Mei Liao,Jun-Ling Chen et al.
Lin-Fei He et al.
Visceral fat has weaker beige adipogenesis than subcutaneous fat with unclear mechanisms. The Wilms tumour gene (Wt1), a visceral adipocyte marker, is highly expressed in visceral adipose tissue (VAT) and visceral adipose-derived stem cells...
A non-invasive method for light-inducible knockout across all cell types in mouse subcutaneous adipose tissue [0.03%]
一种在小鼠皮下脂肪组织所有细胞类型中进行光诱导敲除的非侵入性方法
Erica de Sousa,Magdalena Blaszkiewicz,Kristy Townsend
Erica de Sousa
Cre recombination is a widely used technique for mechanistic insights in physiology and disease. However, available constitutive and inducible Cre systems present challenges that can be prohibitive for some study designs. For example, Cre e...
mTORC2 regulates lipid metabolism-driven TAMs via the PPAR-γ/CD36 pathway to promote liposarcoma progression [0.03%]
mTORC2通过PPAR-γ/CD36通路调节脂代谢驱动的巨噬细胞促进脂肪肉瘤进展
Weihua Xiao,Jingdan Sheng,Chunjiao Liu et al.
Weihua Xiao et al.
Tumour-associated macrophages (TAMs) exert a pivotal function in tumour progression, and M2-type TAMs are closely linked to tumour-promoting functions. Mechanistic target of rapamycin complex 2 (mTORC2) may mediate TAM polarization and subs...
Hao Liu,Jie Chen,Dan-Qi Qiu et al.
Hao Liu et al.
Obesity is one of the most significant health challenges today, with its prevalence increasing rapidly worldwide. The associated inflammatory state is a major risk factor for developing type 2 diabetes, cardiovascular diseases, and sleep ap...
The adiponectin/leptin ratio as a biomarker of adiposopathy and visceral adipose tissue accumulation: sex-specific mechanisms [0.03%]
脂联素/瘦素比值作为脂肪病理和内脏脂肪积累生物标志物的性别差异机制研究
Aida Medina-Urrutia,Iván Torre-Villalvazo,Andrea Díaz-Villaseñor et al.
Aida Medina-Urrutia et al.
Adipose tissue (AT) dysfunction can lead to increased visceral AT (VAT) and metabolic damage. The adiponectin/leptin ratio (ALR) has been proposed as a biomarker of AT functionality. However, its participation in VAT accumulation and the im...
Hypotonic induced volume activated chloride current in 3T3-L1 preadipocytes and its effect on cell differentiation [0.03%]
低渗诱导的3T3-L1前脂肪细胞容积激活氯电流及其对细胞分化的影响
Hua Guan,Zhenghao Huang,Ziyue Wang et al.
Hua Guan et al.
Volume-activated chloride current (VACC), the most common and abundant anion current in organisms, is involved in various physiological and pathological processes. However, its expression and characteristics in preadipocytes remain unclear....
The transcription elongation factors Spt4 and Spt6 promote dermal adipocyte differentiation [0.03%]
转录延伸因子Spt4和Spt6能够促进真皮脂肪细胞分化
Julian Gomez,Samiksha Mahapatra,Uyanga Batzorig et al.
Julian Gomez et al.
Regulation of adipogenesis has classically been viewed through the lens of transcription initiation driven by lineage defining transcription factors. In this study, we uncover transcription elongation as a critical and previously underappre...
Super-enhancer-associated miR-1260b coordinates adipogenesis and metabolic programming in human adipose stem cells [0.03%]
人源脂肪干细胞中与超级增强子相关的miR-1260b调控脂质生成及代谢重编程
Sen Li,Shuhui Ji,Zihan Yu et al.
Sen Li et al.
Obesity and its metabolic complications represent a major and growing public health burden, for which effective therapeutic strategies remain limited. Although super-enhancers are recognized as key regulators of cell identity and adipogenes...