Disrupted adipokine secretion and inflammatory responses in human adipocyte hypertrophy [0.03%]
人类脂肪细胞肥大过程中脂肪细胞因子分泌及炎症反应的变化规律研究
Dan Gao,Chen Bing,Helen R Griffiths
Dan Gao
Adipocyte hypertrophy is a critical contributor to obesity-induced inflammation and insulin resistance. This study employed a human adipocyte hypertrophy model to investigate the adipokine release, inflammatory responses, and the intracellu...
Adipose tissue and adipose-derived stromal cells can reduce skin contraction in an in vitro tissue engineered full thickness skin model [0.03%]
脂肪组织和脂肪来源的基质细胞可以在体外工程化全厚度皮肤模型中减少皮肤收缩
Victoria L Workman,Anna-Victoria Giblin,Nicola H Green et al.
Victoria L Workman et al.
Skin contracts during wound healing to facilitate wound closure. In some patients, skin contraction can lead to the formation of skin contractures that limit movement, impair function, and significantly impact well-being. Current treatment ...
Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue [0.03%]
TAK-981对SUMOylation的药理抑制模仿了小鼠 perigonadal白色脂肪组织中的遗传HypoSUMOylation现象
Damien Dufour,Xu Zhao,Florian Chaleil et al.
Damien Dufour et al.
Post-translational modification by the small ubiquitin-like modifier (SUMO) is essential for cellular differentiation and homeostasis. Here, we investigate the role of SUMOylation in adipose tissue development using TAK-981, a pharmacologic...
miR-6402 targets Bmpr2 and negatively regulates mouse adipogenesis [0.03%]
miR-6402靶向Bmpr2并负调节小鼠脂肪形成过程
Malaz Elsheikh,Tomomi Sano,Akiko Mizokami et al.
Malaz Elsheikh et al.
Obesity is characterized by macrophage infiltration into adipose tissue. White adipose tissue remodelling under inflammatory conditions involves both hypertrophy and adipogenesis and is regulated by transcription factors, which are influenc...
Adipogenic dedifferentiation enhances survival of human umbilical cord-derived mesenchymal stem cells under oxidative stress [0.03%]
脂肪细胞去分化可提高人脐带间充质干细胞在氧化应激环境中的存活率
Yin Yuan,Meina Kuang,Tengye Yu et al.
Yin Yuan et al.
Mesenchymal stem cells (MSCs) serve as ideal candidates for a broad range of cell-based therapies. However, cell ageing caused by long-term in vitro expansion and poor survival after in vivo delivery greatly limits their success in preclini...
Lea M Merz,Karsten Winter,Sandy Richter et al.
Lea M Merz et al.
Phosphatase and tensin homolog (PTEN) hamartoma tumour syndrome (PHTS) is a rare disorder caused by germline mutations in the tumour suppressor gene PTEN, a key negative regulator of phosphatidylinositol 3-kinase (PI3K)/AKT signalling. Chil...
Bioinformatics analysis identifies key secretory protein-encoding differentially expressed genes in adipose tissue of metabolic syndrome [0.03%]
生物信息学分析鉴定代谢综合征脂肪组织中差异表达的关键分泌蛋白编码基因
Jiandong Zhou,Yunshan Guo,Xuan Liu et al.
Jiandong Zhou et al.
The objective of this study was to identify key secretory protein-encoding differentially expressed genes (SP-DEGs) in adipose tissue in female metabolic syndrome, thus detecting potential targets in treatment. We examined gene expression p...
Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue [0.03%]
Angiotensin 1-7的抗炎作用及在白色脂肪组织中的作用机制研究
Nozomi Nishida,Satoru Sugimoto,Satoshi Miyagaki et al.
Nozomi Nishida et al.
Obesity is a global health concern that promotes chronic low-grade inflammation, leading to insulin resistance, a key factor in many metabolic diseases. Angiotensin 1-7 (Ang 1-7), a component of the renin-angiotensin system (RAS), exhibits ...
Correlation analysis of key genes and immune infiltration in visceral adipose tissue and subcutaneous adipose tissue of patients with type 2 diabetes in women [0.03%]
女性2型糖尿病患者内脏脂肪组织和皮下脂肪组织关键基因与免疫浸润相关性分析
Qian Shi,Yongxin Li,Chunyan Liu et al.
Qian Shi et al.
Immune cell infiltration into adipose tissue (AT) is a key factor in type 2 diabetes (T2DM). However, research on the impact of fat distribution on immune cells and immune responses in women is still lacking. This study used enrichment, pro...
Research progress on the pathogenesis of multiple symmetrical lipomatosis [0.03%]
多发性对称性脂肪瘤病发病机制的研究进展
Bo Hu,Ze Wang,Tengxiao Ma et al.
Bo Hu et al.
Multiple symmetric lipomatosis, also known as madelung's disease, is a rare syndrome characterized by the accumulation of multiple symmetric subcutaneous adipose tissues that significantly affect patients' quality of life. Since the aetiolo...