Adipose tissue explant culture using PDMS flow chambers: an alternative to static explant culture [0.03%]
基于PDMS流动腔的脂肪组织切片培养：静态切片培养的一种替代方法
M Cohen,P Bandaru,K Szylo et al.
M Cohen et al.
As obesity rates continue to rise, it is important that we can effectively study adipose tissue to understand its physiological contribution in individuals with obesity. Unfortunately, due to the fragility and buoyancy of adipose tissue, cu...
Molecular mechanisms of propolis in adipogenesis, lipid metabolism and white adipose tissue Browning: a systematic review of preclinical studies [0.03%]
巴西蜂胶在脂肪细胞生成、脂质代谢和白色脂肪组织褐变的分子机制：对临床前研究的系统性综述
Imam Megantara,Putri Karisa,Wahana Inova Pakpahan et al.
Imam Megantara et al.
White adipose tissue (WAT) browning has gained increasing attention as potential strategy for obesity management. The conversion of WAT into brown adipose tissue (BAT) enhances energy expenditure and improves metabolic health. Propolis, nat...
A compendium of adipocyte morphologies across different breast pathologies [0.03%]
不同乳腺病理中脂肪细胞形态学的汇编
Abigail Dodson,Katie Hanna,Kerri Palmer et al.
Abigail Dodson et al.
Adipocytes are abundant in the breast tissue microenvironment. In breast cancer, they can change morphologically according to their proximity to tumour cells, with the closest becoming cancer-associated adipocytes (CAAs). It remains unclear...
Fatty acid composition of lipid fractions in white- and brown-like adipocytes derived from human mesenchymal stem cells [0.03%]
源自人类间充质干细胞的白色和类似褐色脂肪细胞脂质组分的脂肪酸组成
Khadijeh Abbasi,Amir Mehdizadeh,Hamed Hamishehkar et al.
Khadijeh Abbasi et al.
White and brown adipocytes differ markedly in lipid composition and metabolic function. White adipocytes primarily serve as energy storage depots, whereas brown adipocytes are mitochondria-rich and specialized for thermogenesis. However, th...
Isabelle Hue,Adèle Branthonne,Manon Thomas et al.
Isabelle Hue et al.
Different adipose tissues (AT) have been described, including subcutaneous and visceral tissues (SCAT and VAT). They display different morphological structures, physiological and metabolic functions. Imaging adipocytes in the whole AT was n...
Development of vascularized adipose organoids from PBMSCs and their application in evaluating Celastrol's effects [0.03%]
基于PBMSC的血管化脂肪器官体外构建及评估Celastrol作用效应的研究
Sen Li,Fangming Kan,Shuhui Ji et al.
Sen Li et al.
Obesity lacks physiologically relevant human models, which constrains in-depth investigation into its underlying mechanisms and hampers the development of effective therapeutic strategies for obesity and its associated comorbidities. Here, ...
Retinoid X receptor γ interacts with peroxisome proliferator-activated receptor-γ to promote browning during adipose tissue differentiation [0.03%]
视黄醇X受体γ通过促进脂肪细胞分化过程中的棕色化与过氧化物酶体增殖激活受体γ相互作用
Defei Chen,Saed Woraikat,Xiong Guo et al.
Defei Chen et al.
Obesity and type 2 diabetes mellitus are global public health challenges. Activating thermogenic adipose tissues, such as brown adipose tissue and beige adipose tissue, could be a promising strategy to combat obesity and consequently obesit...
Hematopoietic stem cell-derived adipocytes suppress leptin production, and attenuate ovariectomy-induced inhibition of physical activity and insulin sensitivity in female mice [0.03%]
造血干细胞来源的脂肪细胞可抑制瘦素产生并减轻卵巢切除引起的雌性小鼠身体活动和胰岛素敏感性下降
Andrew E Libby,Timothy M Sullivan,Joanne K Maltzahn et al.
Andrew E Libby et al.
A subpopulation of adipocytes in mice and humans is produced from haematopoietic stem cells rather than mesenchymal progenitors; the source of conventional white and brown/beige adipocytes. The abundance of these haematopoietic stem cell-de...
High-throughput measurement of adipocyte size with open-source software using whole-slide adipose tissue images [0.03%]
利用整个脂肪组织图像开源软件进行高通量测量脂肪细胞大小
Alan Ramalho,Marie-Frédérique Gauthier,Ina Maltais-Payette et al.
Alan Ramalho et al.
The aim of this study was to create and validate a high-throughput method based on open-source software for the measurement of adipocyte diameters in white adipose tissue histological sections. Human omental and subcutaneous adipose tissue ...
Ultrastructural characterization of white adipocytes in a mouse model with enhanced sequestration of fatty acids in adipose tissue [0.03%]
一种小鼠模型的白色脂肪细胞 ultra 结构特征化 该模型可增强脂肪组织中脂肪酸的隔离作用
Yi Zhang,Keigo Tomoo,Yen-Hsi Lai et al.
Yi Zhang et al.
Sequestration of free fatty acids (FFA) inside white adipose tissue (WAT) may reduce plasma FFA levels and prevent lipotoxicity in other organs. However, it is poorly understood how WAT responds to this metabolic stress. As albumin promotes...