Erianin inhibits 3T3-L1 adipocyte differentiation through downregulation of CCAAT-enhancer binding protein-α and peroxisome proliferator-activated receptor-γ, lipogenic genes and impairment of mitochondrial respiration [0.03%]
姜黄素通过下调CCAAT增强子结合蛋白-α和过氧化物酶体增殖激活受体-γ，脂生成基因以及线粒体呼吸紊乱抑制3T3-L1脂肪细胞分化
Hathaichanok Yimpreeda,Chayanee Laowittawat,Siraprapa Siritutsoontorn et al.
Hathaichanok Yimpreeda et al.
Erianin, a natural bibenzyl compound, has recently garnered attention owing to its diverse biological activities. In the present study, we investigated the effects of Erianin on adipocyte differentiation, lipid metabolism, and mitochondrial...
CAPG enhances adipogenesis and inflammatory cytokine expression in adipocytes [0.03%]
CAPG促进脂肪细胞的脂肪生成及炎性因子表达
Luyao Zhang,Botao Sang,Sainan Li et al.
Luyao Zhang et al.
The expression of CAPG (capping actin protein, gelsolin-like) is upregulated in visceral white adipose tissue of high-fat diet -fed mice; however, its impact on adipocyte functionality remains unclear. We observed upregulated CAPG expressio...
Investigating the contribution of circulating inflammatory cytokines on the link between obesity and COVID-19 [0.03%]
探究循环炎症细胞因子在肥胖和COVID-19关联中的作用贡献
Zahra J Khamis,Emmanouil Karteris,Amani Alhajeri et al.
Zahra J Khamis et al.
Coronavirus disease 2019 (COVID-19) is more severe in obesity. A cytokine storm was observed in critically ill patients. Since adipose tissue secretes cytokines, we investigated whether cytokines mediate the effect of obesity on COVID-19 se...
Comparative analysis of adipose tissue mitophagy and inflammatory markers in obesity and health [0.03%]
肥胖与健康对照组中比较分析脂肪组织线粒体自噬和炎症标志物
Shaghayegh Mohammadzadeh,Mitra Nourbakhsh,Parichehreh Yaghmaei et al.
Shaghayegh Mohammadzadeh et al.
Obesity is associated with chronic inflammation and disruptions in cellular homeostasis, including impaired autophagy in adipose tissue. This study aimed to investigate the key mitophagy markers in the adipose tissue of individuals with obe...
Comparative Study
Adipocyte. 2025 Dec;14(1):2596407. DOI:10.1080/21623945.2025.2596407 2025
Discovery of a bell-shaped dose response curve to melanin-concentrating hormone in the 3T3-L1 adipocyte model: low-dose MCH facilitates adipogenesis [0.03%]
黑色素浓缩激素在3T3-L1脂肪细胞模型中的剂量效应关系呈钟形曲线：低剂量MCH促进脂肪生成
Laurie B Cook,Colin M King,Hiba Y Abdullah
Laurie B Cook
Melanin-concentrating hormone signalling pathways in the central nervous system are of significant clinical interest in treating appetite, sleep, and mood disorders. However, with the additional discovery of active MCH signalling pathways i...
WDR4-mediate tRNA m7G modification to promote mitophagy and browning of white adipose tissue for ameliorating obesity in male mice [0.03%]
WDR4介导的tRNA m7G修饰通过促进线粒体自噬和白色脂肪组织褐变改善雄性小鼠肥胖症状
Beisi Lin,Chaofan Wang,Yanling Yang et al.
Beisi Lin et al.
Objective: Brown adipose tissue activation is a potential anti-obesity strategy. N7-methylguanosine (m7G) modification is a novel RNA epigenetic modification, but its role in adipose metabolism remains unexplored. ...
Electroacupuncture pretreatment alleviates myocardial ischemia injury via brown adipose tissue and BMP3b/Smad1/5 pathway in mice [0.03%]
电针预处理通过棕色脂肪组织和BMP3b/Smad1/5信号通路减轻小鼠心肌缺血损伤
Yuhang Yan,Danying Qian,Xiaohan Lu et al.
Yuhang Yan et al.
Acute myocardial infarction (AMI) is a critical condition that induces myocardial ischaemic injury and necrosis, requiring timely intervention to improve outcomes. Emerging evidence suggests that brown adipose tissue (BAT) plays a crucial r...
Identification of SDC4 as a potential target for obesity via integrated analysis of the lncRNA-miRNA-mRNA network in visceral adipose tissue [0.03%]
整合分析内脏脂肪组织中的长链非编码RNA-微小RNA-信使RNA网络鉴定肥胖的潜在治疗靶点SDC4
Yuancheng Shao,Feng Ju,Jun Qian et al.
Yuancheng Shao et al.
Obesity is a major global health issue. This study aimed to elucidate its molecular mechanisms by analysing the expression of lncRNAs, miRNAs, and mRNAs in visceral adipose tissue. Through integrated transcriptome sequencing and bioinformat...
Crosstalk between microRNAs and autophagy in adipocyte differentiation: emerging therapeutic targets for obesity [0.03%]
微小核糖核酸和自噬在脂肪细胞分化中的串扰：肥胖的潜在治疗靶点
Shan Gao
Shan Gao
Obesity remains a global health challenge, underscoring the need for more effective therapeutic strategies. Recent evidence highlights the central role of adipose tissue autophagy in metabolic homoeostasis, with its dysregulation contributi...
In vivo evidence supports the effectiveness of the longevity-associated protein LAV-BPIFB4 in reducing adipose tissue-derived mediators of systemic inflammation to prevent vascular insult and atheromatous change [0.03%]
体内证据支持长寿相关蛋白LAV-BPIFB4通过减少脂肪组织介导的全身炎症因子来预防血管损伤和动脉粥样变性
Elena Ciaglia,Valentina Lopardo,Francesco Montella et al.
Elena Ciaglia et al.
Obesity triggers chronic low-grade inflammation contributing to cardiovascular and metabolic diseases. Over-release of adipokines and pro-inflammatory mediators by white adipose tissue (WAT) enhances inflammation through a feedforward loop ...