Bryony Leeke,Judith Marsman,Justin M O&#x;Sullivan et al.
Bryony Leeke et al.
Recently, whole genome sequencing approaches have pinpointed mutations in genes that were previously not associated with cancer. For Acute Myeloid Leukaemia (AML), and other myeloid disorders, these approaches revealed a high prevalence of ...
Expression and diagnostic values of calretinin and CK5/6 in cholangiocarcinoma [0.03%]
钙结合蛋白和CK5/6在胆管癌的表达及诊断价值评估
Lanjing Zhang,Renee Frank,Emma E Furth et al.
Lanjing Zhang et al.
Background: Mesothelin, a mesothelial marker, has been found expressed in and as a potential treatment target of cholangioacarcinoma (CC). It is possible that CC may be derived from the cells sharing mesothelial markers. ...
Single low-dose rHuIL-12 safely triggers multilineage hematopoietic and immune-mediated effects [0.03%]
单剂量rHuIL-12安全诱导多谱系造血作用和免疫介导的作用
Mamata S Gokhale,Vladimir Vainstein,Jamie Tom et al.
Mamata S Gokhale et al.
Background: Recombinant human interleukin 12 (rHuIL-12) regulates hematopoiesis and cell-mediated immunity. Based on these hematopoietic and immunomodulatory activities, a recombinant human IL-12 (rHuIL-12) is now under d...
Survival and hospitalization among patients with acute myeloid leukemia treated with azacitidine or decitabine in a large managed care population: a real-world, retrospective, claims-based, comparative analysis [0.03%]
在大型管理式护理人群中使用阿扎胞苷或地西他滨治疗的急性髓系白血病患者的生存率和住院情况：基于理赔数据的回顾性、对比分析
B Douglas Smith,Charles L Beach,Dalia Mahmoud et al.
B Douglas Smith et al.
Background: This study examined patient outcomes using real world data for acute myeloid leukemia (AML) patients initiating treatment. Methods: ...
Vitamin D3 potentiates the antitumorigenic effects of arsenic trioxide in human leukemia (HL-60) cells [0.03%]
维生素D3能够增强三氧化二砷在人类白血病(HL-60)细胞中的抑癌功效
Christian S Rogers,Clement G Yedjou,Dwayne J Sutton et al.
Christian S Rogers et al.
Background: Arsenic trioxide (ATO) is a novel form of therapy that has been found to aid acute promyelocytic leukemia (APL) patients. Our laboratory has demonstrated that ATO-induced cytotoxicity in human leukemia (HL-60)...
Acute myeloid leukemia with t(7;21)(p22;q22) and 5q deletion: a case report and literature review [0.03%]
涉及t(7;21)(p22;q22)和5q-的急性髓系白血病一例报告及文献复习
Jianling Ji,Eric Loo,Sheeja Pullarkat et al.
Jianling Ji et al.
The gene RUNX1 at chromosome 21q22 encodes the alpha subunit of Core binding factor (CBF), a heterodimeric transcription factor involved in the development of normal hematopoiesis. Translocations of RUNX1 are seen in several types of leukem...
Lymphocytes from chronic lymphocytic leukaemia undergo ABL1-linked amoeboid motility and homotypic interaction as an early adaptive change to ex vivo culture [0.03%]
慢性淋巴细胞白血病淋巴细胞在体外培养早期发生ABL1介导的变形运动和同型相互作用适应性变化
Claire V Hutchinson,Shiva Natarajan,Suzanne M Johnson et al.
Claire V Hutchinson et al.
Background: Those stimuli that together promote the survival, differentiation and proliferation of the abnormal B-lymphocytes of chronic lymphocytic leukaemia (CLL) are encountered within tissues, where together they form...
A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation [0.03%]
一例起源于携带JAK2-V617F突变克隆之外的克隆的原发性骨髓增生性肿瘤相关急性淋巴细胞白血病的病例报告
Yuya Nagai,Masahiro Kawahara,Noriko Sugino et al.
Yuya Nagai et al.
Here we report on a case of Philadelphia chromosome positive B lymphoblastic leukemia (Ph+ALL), which developed following a long duration of essential thrombocythemia (ET). A mutational analysis of Janus Kinase 2 (JAK2) revealed that the V6...
Tumor dormancy: potential therapeutic target in tumor recurrence and metastasis prevention [0.03%]
肿瘤休眠：预防肿瘤复发和转移的潜在治疗靶点
Sih-Han Wang,Shiaw-Yih Lin
Sih-Han Wang
In past decades, cancer patient survival has been improved with earlier detection and advancements in therapy. However, many patients who exhibit no clinical symptoms after frontline therapy subsequently suffer, often many years later, aggr...
Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies [0.03%]
代谢性乳腺癌的临床病理特征、预后因素和系统治疗策略
Theresa L Schwartz,Harveshp Mogal,Christos Papageorgiou et al.
Theresa L Schwartz et al.
Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatment options are available for MB...