Vincristine could partly suppress stromal support to T-ALL blasts during pegylated arginase I treatment [0.03%]
长春新碱可以部分抑制血管细胞对T-ALL细胞的支持作用 Pegylated精氨酸酶I疗法期间出现
Fung Kwong-Lam,Chan Godfrey Chi-Fung
Fung Kwong-Lam
Background: Relapsed T-lineage acute lymphoblastic leukemia (T-ALL) has been an incurable disease. Recent reports showed that an L-arginine depleting enzyme, pegylated arginase (BCT-100) may be effective against T-ALL cel...
Increased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia [0.03%]
T淋巴细胞急性淋巴细胞性白血病中miR-221表达增强与总生存期缩短有关
Hamilton L Gimenes-Teixeira,Antonio R Lucena-Araujo,Guilherme A Dos Santos et al.
Hamilton L Gimenes-Teixeira et al.
Background: CD56 expression has been associated with a poor prognosis in lymphoid neoplasms, including T-cell acute lymphoblastic leukemia (T-ALL). MicroRNAs (miRNAs) play an important role in lymphoid differentiation, an...
Bone marrow non-mesenchymal mononuclear cells induce functional differentiation of neuroblastoma cells [0.03%]
骨髓非间质单核细胞诱导神经母细胞瘤细胞的功能分化
Chareerut Phruksaniyom,Permphan Dharmasaroja,Surapol Issaragrisil
Chareerut Phruksaniyom
Less is known about the non-mesenchymal mononuclear cell fraction of human bone marrow on functional adaptation of neuroblastoma cells. Using immunocytochemistry, we showed that bone-marrow mononuclear cell (BMMC)-conditioned medium can ind...
Genetic profiles of plasmacytoid (BDCA-4 expressing) DC subtypes-clues to DC subtype function in vivo [0.03%]
浆细胞样树突状细胞亚型的基因表达特征及对体内DC功能的研究提示
Stephen H Wrzesinski,Jan L Fisher,Marc S Ernstoff
Stephen H Wrzesinski
Among the dendritic cell (DC) subsets, plasmacytoid DC's (pDC) are thought to be important in the generation of both antiviral and antitumor responses. While pDC may be useful in developing dendritic cell-based tumor vaccines, the low frequ...
A standardized microarray assay for the independent gene expression markers in AML: EVI1 and BAALC [0.03%]
急性髓系白血病独立基因表达标志EVI1和BAALC的微阵列检测方法
Jaap Brand,Martin H van Vliet,Leonie de Best et al.
Jaap Brand et al.
High levels of BAALC, ERG, EVI1 and MN1 expression have been associated with shorter overall survival in AML but standardized and clinically validated assays are lacking. We have therefore developed and optimized an assay for standardized d...
The forgotten tale of immunoglobulin allotypes in cancer risk and treatment [0.03%]
免疫球蛋白基因型在癌症风险和治疗中的作用被遗忘了？
Janardan P Pandey,Zihai Li
Janardan P Pandey
Monoclonal antibody (mAb) has fulfilled the promise of being the "Magic Bullet" in oncology with the clinical success of mAbs against CD20, Her-2/neu, epidermal growth factor receptor, vascular endothelial cell growth factor and others in a...
The relative efficacy of imatinib, dasatinib and nilotinib for newly diagnosed chronic myeloid leukemia: a systematic review and network meta-analysis [0.03%]
伊马替尼、达沙替尼和尼洛替尼治疗新诊断的慢性髓性白血病相对有效性的系统评价和网络 meta 分析
Stuart Mealing,Leticia Barcena,Neil Hawkins et al.
Stuart Mealing et al.
Objectives: Dasatinib 100 mg daily and nilotinib 600/800 mg daily have been compared to imatinib as first line treatments for CML in two recent randomised studies. However, no head to head evidence exists of the relative ...
Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma [0.03%]
针对早期B细胞受体信号传导可诱导恶性套细胞淋巴瘤发生凋亡
Mohand-Akli Boukhiar,Claudine Roger,Julie Tran et al.
Mohand-Akli Boukhiar et al.
Background: We previously showed that B-cell receptor (BCR) signaling pathways are important for in vitro survival of mantle cell lymphoma (MCL) cells. To further identify early BCR-activated signaling pathways involved i...
Clinical and laboratory characteristics of adolescents with platelet function disorders and heavy menstrual bleeding [0.03%]
青少年血小板功能障碍并重度月经过多的临床及实验室特点分析
Lawrence S Amesse,Teresa Pfaff-Amesse,William T Gunning et al.
Lawrence S Amesse et al.
Background: Platelet function disorders (PFDs) have emerged as an important etiology of heavy menstrual bleeding (HMB) in adolescents. However, neither clinical nor laboratory data have been methodically analyzed in this ...
Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors [0.03%]
人B细胞中苯扎莫司汀耐药的克服：补体依赖性细胞毒性和环氧酮不可逆蛋白酶体抑制剂的作用
Sue Ellen Verbrugge,Marjon Al,Yehuda G Assaraf et al.
Sue Ellen Verbrugge et al.
Background: In clinical and experimental settings, antibody-based anti-CD20/rituximab and small molecule proteasome inhibitor (PI) bortezomib (BTZ) treatment proved effective modalities for B cell depletion in lymphoproli...