Validation of a microRNA profile in urine liquid biopsy with diagnostic and stratification value for bladder cancer classification, available through the open app BladdermiRaCan [0.03%]
通过开源应用程序BladdermiRaCan进行膀胱癌分类的尿液液体活检中microRNA谱系验证及其诊断和分层价值评估
Julia Oto,Raquel Herranz,Emma Plana et al.
Julia Oto et al.
We aimed to identify a profile of urine microRNAs (miRNAs) with diagnostic and stratification potential in the whole range of bladder cancer (BC) categories, to avoid current invasive, harmful and expensive procedures. We collected a first ...
Correction: AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition [0.03%]
纠正：AOH1996通过线粒体PCNA抑制作用靶向白血病干细胞的线粒体动力学和代谢
HyunJun Kang,Melissa Valerio,Jia Feng et al.
HyunJun Kang et al.
Published Erratum
Experimental hematology & oncology. 2025 Apr 10;14(1):56. DOI:10.1186/s40164-025-00650-7 2025
Pan Gao,Yang Zhang,Jun Ma et al.
Pan Gao et al.
Chronic lymphocytic leukemia (CLL) is characterized as a clonal proliferation of mature B lymphocytes with distinct immunophenotypic traits, predominantly affecting the middle-aged and elderly population. This condition is marked by an accu...
GLS2 inhibition synergizes with copper to reprogram TCA cycle for cuproptosis-driven radiosensitization in esophageal cancer [0.03%]
GLS2抑制与铜协同作用重新编程三羧酸循环以驱动食管癌的铜死亡放射增敏作用
Wang Jing,Wenhao Wang,Yi Ding et al.
Wang Jing et al.
Esophageal squamous cell carcinoma (ESCC) is notorious for its poor prognosis. In the present study, the role of glutaminase 2 (GLS2) and copper (Cu) in the radiosensitivity of ESCC was explored. Both in vitro and in vivo experiments were c...
Extracellular matrix stiffness: mechanisms in tumor progression and therapeutic potential in cancer [0.03%]
细胞外基质硬度：肿瘤进展中的机制及其在癌症治疗中的潜力
Meiling Zhang,Bin Zhang
Meiling Zhang
Tumor microenvironment (TME) is a complex ecosystem composed of both cellular and non-cellular components that surround tumor tissue. The extracellular matrix (ECM) is a key component of the TME, performing multiple essential functions by p...
NKG2D/CD28 chimeric receptor boosts cytotoxicity and durability of CAR-T cells for solid and hematological tumors [0.03%]
NKG2D/CD28嵌合受体增强CAR-T细胞对实体瘤和血液系统肿瘤的细胞毒性和持久性
Xia Teng,Shance Li,Chaoting Zhang et al.
Xia Teng et al.
Background: CAR-T cell therapy faces challenges in solid tumor treatment and hematologic malignancy relapse, among which the limited persistence of CAR-T cells and target antigen downregulation are prominent factors. Ther...
Interleukin-21 engineering enhances CD19-specific CAR-NK cell activity against B-cell lymphoma via enriched metabolic pathways [0.03%]
通过增强代谢途径工程化IL-21可增强CAR-NK细胞特异性杀伤CD19阳性B淋巴瘤细胞活性
Bailin He,Hong Chen,Jiaxu Wu et al.
Bailin He et al.
Background: NK cells engineered to express interleukin-15 (IL-15) and a CD19-targeted chimeric antigen receptor (CAR) have been used to treat patients with relapsed and/or refractory B cell malignances, demonstrating enco...
Correction: Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain [0.03%]
关于PD1胞外区修饰的嵌合抗原受体T细胞靶向性和杀伤活性的校正文章
Ang Zhang,Shenyu Wang,Yao Sun et al.
Ang Zhang et al.
Published Erratum
Experimental hematology & oncology. 2025 Apr 2;14(1):50. DOI:10.1186/s40164-025-00645-4 2025
RNA modifications in the tumor microenvironment: insights into the cancer-immunity cycle and beyond [0.03%]
肿瘤微环境中的RNA修饰：对癌症免疫循环及其以外领域的洞察
You-Peng Ding,Cui-Cui Liu,Ke-Da Yu
You-Peng Ding
The chemical modification of biological molecules is a critical regulatory mechanism for controlling molecular functions. Although research has long focused on DNA and proteins, RNA modifications have recently attracted substantial interest...
Siltuximab for the treatment of early complications after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia in children, adolescents, and young adults [0.03%]
用于儿童、青少年和年轻成人急性淋巴细胞白血病接受嵌合抗原受体T细胞治疗后早期并发症的西利珠单抗疗法
Víctor Galán-Gómez,Berta González-Martínez,Anna Alonso-Saladrigues et al.
Víctor Galán-Gómez et al.
Background: Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are complications associated with CAR T-cell therapy. Siltuximab directly binds interleukin-6 (IL-6) and may b...