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Mitotic MTH1 inhibitor karonudib kills epithelial ovarian cancer independent of platinum sensitivity

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The prognosis for women with ovarian cancer (OC) is particularly poor if resistance to platinum compounds, the mainstay of standard-of-care therapy, develops. Inhibitors of the Nudix hydrolase MuT Homolog 1 (MTH1) have previously been shown to arrest cancer ce... ...