Hypoxia-induced downregulation of microRNA-186-5p in endothelial cells promotes non-small cell lung cancer angiogenesis by upregulating protein kinase C alpha [0.03%]
缺氧通过下调内皮细胞中microRNA-186-5p促进蛋白激酶Cα表达从而诱导非小细胞肺癌新生血管形成
Vivien Becker,Xu Yuan,Anne S Boewe et al.
Vivien Becker et al.
The tumor microenvironment stimulates the angiogenic activity of endothelial cells (ECs) to facilitate tumor vascularization, growth, and metastasis. The involvement of microRNA-186-5p (miR-186) in regulating the aberrant activity of tumor-...
Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice [0.03%]
经ENA修饰的反义寡核苷酸瞬时降低TDP-43可维持ALS/FTD小鼠的长期治疗效果
Toshihide Takeuchi,Kazuhiro Maeta,Xin Ding et al.
Toshihide Takeuchi et al.
The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although how TDP-43 forms cytoplasmic aggregates and cau...
Exon definitive regions for MPC1 microexon splicing and its usage for splicing modulation [0.03%]
MPC1微外显子剪接的外显子确定区域及其在剪接调控中的应用
Eunjin Koh,Daye Shin,Kyung-Sup Kim
Eunjin Koh
Alternative splicing of microexons (3-30 base pairs [bp]) is involved in important biological processes in brain development and human cancers. However, understanding a splicing process of non-3x bp microexons is scarce. We showed that 4 bp...
Rapid molecular imaging of active thrombi in vivo using aptamer-antidote probes [0.03%]
基于适配体和拮抗剂探针的活体内血栓分子成像技术
Bethany Powell Gray,Linsley Kelly,Kady-Ann Steen-Burrell et al.
Bethany Powell Gray et al.
Pathological blood clotting, or thrombosis, limits vital blood flow to organs; such deprivation can lead to catastrophic events including myocardial infarction, pulmonary embolism, and ischemic stroke. Prompt restoration of blood flow great...
Natural selection of the D614G mutation in SARS-CoV-2 Omicron (B.1.1.529) variant and its subvariants [0.03%]
SARS-CoV-2奥密克戎变异株及其亚型中D614G突变的自然选择作用
Chiranjib Chakraborty,Abinit Saha,Manojit Bhattacharya et al.
Chiranjib Chakraborty et al.
Aptamer-programmable adeno-associated viral vectors as a novel platform for cell-specific gene transfer [0.03%]
适配体编程的腺相关病毒载体作为细胞特异性基因转移的新平台
Francesco Puzzo,Chuanling Zhang,Bethany Powell Gray et al.
Francesco Puzzo et al.
Adeno-associated viruses (AAVs) are commonly used for in vivo gene therapy. Nevertheless, the wide tropism that characterizes these vectors limits specific targeting to a particular cell type or tissue. Here, we developed new chemically mod...
Discovery of DNA aptamers targeting SARS-CoV-2 nucleocapsid protein and protein-binding epitopes for label-free COVID-19 diagnostics [0.03%]
用于无标记诊断的SARS-CoV-2核衣壳蛋白DNA适配体及蛋白质结合抗原表位的鉴定
Suttinee Poolsup,Emil Zaripov,Nico Hüttmann et al.
Suttinee Poolsup et al.
The spread of COVID-19 has affected billions of people across the globe, and the diagnosis of viral infection still needs improvement. Because of high immunogenicity and abundant expression during viral infection, SARS-CoV-2 nucleocapsid (N...
CRISPR-Cas9 editing of a TNPO3 mutation in a muscle cell model of limb-girdle muscular dystrophy type D2 [0.03%]
在肢带肌营养不良症D2型肌肉细胞模型中编辑TNPO3突变体的CRISPR-Cas9技术
Javier Poyatos-García,Águeda Blázquez-Bernal,Marta Selva-Giménez et al.
Javier Poyatos-García et al.
A single-nucleotide deletion in the stop codon of the nuclear import receptor transportin-3 (TNPO3), also involved in human immunodeficiency virus type 1 (HIV-1) infection, causes the ultrarare autosomal dominant disease limb-girdle muscula...
Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis [0.03%]
靶向补体C5的高效siRNA鉴定及其在重症肌无力和胶原诱导性关节炎临前模型中的显著活性
Yoshikazu Kuboi,Yuta Suzuki,Sotaro Motoi et al.
Yoshikazu Kuboi et al.
Complement component 5 (C5), an important molecule in the complement cascade, blockade by antibodies shows clinical efficacy in treating complement-mediated disorders. However, insufficient blockading induced by single-nucleotide polymorphi...