Royal jelly extracellular vesicles promote wound healing by modulating underlying cellular responses [0.03%]
royal jelly外泌体通过调节细胞内在反应促进伤口愈合
Simón Álvarez,Pamina Contreras-Kallens,Sebastian Aguayo et al.
Simón Álvarez et al.
Apis mellifera royal jelly (RJ) is a well-known remedy in traditional medicine around the world and its versatile effects range from antibacterial to anti-inflammatory properties and pro-regenerative properties. As a glandular product, RJ h...
Gene network landscape of mouse splenocytes reveals integrin complex as the A151 ODN-responsive hub molecule in the immune transcriptome [0.03%]
小鼠脾细胞基因调控网络景观分析揭示整合素复合体为A151 ODN响应的免疫转录组核心分子
Volkan Yazar,Ismail Cem Yilmaz,Artun Bulbul et al.
Volkan Yazar et al.
Homeostatic restoration of an inflammatory response requires quenching of the immune system after pathogen threats vanish. A continued assault orchestrated by host defense results in tissue destruction or autoimmunity. A151 is the epitome o...
Identification of a novel small-molecule inhibitor of miR-29b attenuates muscle atrophy [0.03%]
一种新型的miR-29b的小分子抑制剂减轻肌肉萎缩效应的鉴定研究
Qi Liu,Weilin Yuan,Yuwei Yan et al.
Qi Liu et al.
Muscle atrophy is debilitating and can be induced by several stressors. Unfortunately, there are no effective pharmacological treatment until now. MicroRNA (miR)-29b is an important target that we identified to be commonly involved in multi...
Eric B Kmiec
Eric B Kmiec
Depleting hepatitis B virus relaxed circular DNA is necessary for resolution of infection by CRISPR-Cas9 [0.03%]
CRISPR-Cas9治愈乙肝病毒需要耗尽乙肝病毒松弛型共价闭合环状DNA
Dmitry Kostyushev,Anastasiya Kostyusheva,Sergey Brezgin et al.
Dmitry Kostyushev et al.
CRISPR-Cas9 systems can directly target the hepatitis B virus (HBV) major genomic form, covalently closed circular DNA (cccDNA), for decay and demonstrate remarkable anti-HBV activity. Here, we demonstrate that CRISPR-Cas9-mediated inactiva...
Increased PRL-1 in BM-derived MSCs triggers anaerobic metabolism via mitochondria in a cholestatic rat model [0.03%]
PRL-1上调的BM-MSCs通过线粒体途径触发胆汁淤积大鼠模型的糖酵解增强现象
Jae Yeon Kim,Se Ho Kim,Jin Seok et al.
Jae Yeon Kim et al.
Mesenchymal stem cell (MSC) therapy in chronic liver disease is associated with mitochondrial anaerobic metabolism. Phosphatase of regenerating liver-1 (PRL-1), known as protein tyrosine phosphatase type 4A, member 1 (PTP4A1), plays a criti...
H Helena Wu,Sarah Leng,Yasser Abuetabh et al.
H Helena Wu et al.
The tumor suppressor p53 plays a critical role in cancer pathogenesis, and regulation of p53 expression is essential for maintaining normal cell growth. UBE4B is an E3/E4 ubiquitin ligase involved in a negative-feedback loop with p53. UBE4B...
Cas9-induced single cut enables highly efficient and template-free repair of a muscular dystrophy causing founder mutation [0.03%]
Cas9介导的单切口修复引起杜氏肌营养不良症的基础突变高效且无需模板修复
Stefanie Müthel,Andreas Marg,Busem Ignak et al.
Stefanie Müthel et al.
With thousands of patients worldwide, CAPN3 c.550delA is the most frequent mutation causing severe, progressive, and untreatable limb girdle muscular dystrophy. We aimed to genetically correct this founder mutation in primary human muscle s...
Forced enhancer-promoter rewiring to alter gene expression in animal models [0.03%]
利用动物模型强制改变增强子-启动子的互作模式以修改基因表达
Scott A Peslak,Selami Demirci,Vemika Chandra et al.
Scott A Peslak et al.
Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (HBG) and adult-type (HBB) β-globin genes during c...
Self-attention enabled deep learning of dihydrouridine (D) modification on mRNAs unveiled a distinct sequence signature from tRNAs [0.03%]
自注意力增强的深度学习揭示了mRNA中DHU位点修饰与tRNA的区别性序列模式
Yue Wang,Xuan Wang,Xiaodong Cui et al.
Yue Wang et al.
Dihydrouridine (D) is a modified pyrimidine nucleotide universally found in viral, prokaryotic, and eukaryotic species. It serves as a metabolic modulator for various pathological conditions, and its elevated levels in tumors are associated...