Inhalation of an RNA aptamer that selectively binds extracellular histones protects from acute lung injury [0.03%]
一种可选择结合细胞外组蛋白的RNA适配体的吸入作用能够保护免受急性肺损伤的影响
Beilei Lei,Chaojian Wang,Kamie Snow et al.
Beilei Lei et al.
Acute lung injury (ALI) is a syndrome of acute inflammation, barrier disruption, and hypoxemic respiratory failure associated with high morbidity and mortality. Diverse conditions lead to ALI, including inhalation of toxic substances, aspir...
Ilayda Sen,Shizuka Uchida,Venkata Naga Srikanth Garikipati
Ilayda Sen
Therapeutic gene correction for Lesch-Nyhan syndrome using CRISPR-mediated base and prime editing [0.03%]
利用CRISPR介导的碱基编辑和先导编辑进行Lesch-Nyhan综合征治疗性基因矫正
Gayoung Jang,Ha Rim Shin,Hyo-Sang Do et al.
Gayoung Jang et al.
Lesch-Nyhan syndrome (LNS) is inherited as an X-linked recessive genetic disorder caused by mutations in hypoxanthine-guanine phosphoribosyl transferase 1 (HPRT1). Patients with LNS show various clinical phenotypes, including hyperuricemia,...
Circular RNA in liquid biopsy as biomarkers toward precision medicine [0.03%]
循环RNA在液体活检中的作用及作为精准医疗中生物标志物的潜力
Yueh-Chun Lee,Huey-En Tzeng,Hui-Hsuan Lin et al.
Yueh-Chun Lee et al.
BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis [0.03%]
BMAL1-TTK-H2Bub1回路缺陷影响了老年骨质疏松介导的骨形成能力
Li Jinteng,Xu Peitao,Yu Wenhui et al.
Li Jinteng et al.
During the aging process, the reduced osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) results in decreased bone formation, which contributes to senile osteoporosis. Previous studies have confirmed that interrupted...
Enzalutamide-induced signatures revealed by epigenetic plasticity using single-cell multi-omics sequencing in prostate cancer [0.03%]
利用单细胞多组学测序技术揭示前列腺癌中enzalutamide诱导的表观遗传可塑性信号素enzealutamide引起的表观遗传可塑性标志物
Huihui Fan,Jinze Li,Astrid M Manuel et al.
Huihui Fan et al.
Prostate cancer is morphologically and molecularly heterogeneous, which poses obstacles for early diagnosis and treatment. Advancements in understanding the heterogeneity of prostate cancer will help navigate through these challenges and ul...
Antisense oligonucleotide therapy corrects splicing in the common Stargardt disease type 1-causing variant ABCA4 c.5461-10T>C [0.03%]
反义寡核苷酸疗法可纠正常见斯塔加德病致病突变ABCA4 c.5461-10T>C的剪接异常
Melita Kaltak,Petra de Bruijn,Davide Piccolo et al.
Melita Kaltak et al.
Stargardt disease type 1 (STGD1) is the most common hereditary form of maculopathy and remains untreatable. STGD1 is caused by biallelic variants in the ABCA4 gene, which encodes the ATP-binding cassette (type 4) protein (ABCA4) that clears...
In vivo base editing rescues photoreceptors in a mouse model of retinitis pigmentosa [0.03%]
在视网膜色素变性小鼠模型中，体内碱基编辑可恢复感光细胞功能
Jing Su,Kaiqin She,Li Song et al.
Jing Su et al.
Retinitis pigmentosa (RP) is a group of retinal diseases that cause the progressive death of retinal photoreceptor cells and eventually blindness. Mutations in the β-domain of the phosphodiesterase 6 (Pde6b) gene are the most identified ca...
Therapeutic phosphorodiamidate morpholino oligonucleotides: Physical properties, solution structures, and folding thermodynamics [0.03%]
治疗性磷吗啉类寡核苷酸：物理性质、溶液结构和折叠热力学
Farkhad Maksudov,Evgenii Kliuchnikov,Daniel Pierson et al.
Farkhad Maksudov et al.
Elucidating the structure-function relationships for therapeutic RNA mimicking phosphorodiamidate morpholino oligonucleotides (PMOs) is challenging due to the lack of information about their structures. While PMOs have been approved by the ...
IPs-GRUAtt: An attention-based bidirectional gated recurrent unit network for predicting phosphorylation sites of SARS-CoV-2 infection [0.03%]
基于注意力机制的双向门控循环单元网络预测SARS-CoV-2感染位点
Guiyang Zhang,Qiang Tang,Pengmian Feng et al.
Guiyang Zhang et al.
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has generated tremendous concern and poses a serious threat to international public health. Phosphorylation is a common post-translational modific...