How well does a data-driven prediction method distinguish dihydrouridine from tRNA and mRNA? [0.03%]
数据驱动的预测方法如何辨别双氢尿苷与tRNA和mRNA？
Shaherin Basith,Balachandran Manavalan
Shaherin Basith
Exosome-mediated inhibition of microRNA-449a promotes the amplification of mouse retinal progenitor cells and enhances their transplantation in retinal degeneration mouse models [0.03%]
外泌体介导的microRNA-449a抑制促进小鼠视网膜祖细胞扩增并增强其在视网膜变性小鼠模型中的移植效果
Chen Jun Guo,Xiu Li Cao,Yu Fei Zhang et al.
Chen Jun Guo et al.
Inherited and age-related retinal degenerations are the commonest causes of blindness without effective treatments. Retinal progenitor cells (RPCs), which have the multipotency to differentiate into various retinal cell types, are regarded ...
High-capacity adenovector delivery of forced CRISPR-Cas9 heterodimers fosters precise chromosomal deletions in human cells [0.03%]
高效腺病毒载体递送强制性CRISPR-Cas9异二聚体促进人类细胞中精确的染色体重排删除
Francesca Tasca,Marcella Brescia,Jin Liu et al.
Francesca Tasca et al.
Genome editing based on dual CRISPR-Cas9 complexes (multiplexes) permits removing specific genomic sequences in living cells leveraging research on functional genomics and genetic therapies. Delivering the required large and multicomponent ...
Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation [0.03%]
意料之外！基因抑制表观遗传"阅读器"EED增强cyclinD1基因活化
Mengxue Zhang,Jing Li,Qingwei Wang et al.
Mengxue Zhang et al.
Epigenetically switched, proliferative vascular smooth muscle cells (SMCs) form neointima, engendering stenotic diseases. Histone-3 lysine-27 trimethylation (H3K27me3) and acetylation (H3K27ac) marks are associated with gene repression and ...
A novel gene therapy for methamphetamine- induced cognitive disorder with a hyper-acidified fusion variant of DnaJB1 [0.03%]
一种新型基因疗法治疗甲基苯丙胺致认知障碍疾病的DnaJB1超酸性融合突变体疗法
Mengru Zhang,Cheng Chen,Qingyan Peng et al.
Mengru Zhang et al.
Methamphetamine (MA) is spread worldwide and is a highly addictive psychostimulant that can induce neurodegeneration and cognitive disorder, which lacks effective treatments. We and other researchers have found that the crucial member of Hs...
Artificial intelligence for drug discovery: Resources, methods, and applications [0.03%]
药物发现中的人工智能：资源、方法及应用
Wei Chen,Xuesong Liu,Sanyin Zhang et al.
Wei Chen et al.
Conventional wet laboratory testing, validations, and synthetic procedures are costly and time-consuming for drug discovery. Advancements in artificial intelligence (AI) techniques have revolutionized their applications to drug discovery. C...
Delivery of anti-microRNA-21 by lung-targeted liposomes for pulmonary fibrosis treatment [0.03%]
肺靶向脂质体递送抗microRNA-21用于肺纤维化治疗
Lingyue Yan,Yafei Su,Isaac Hsia et al.
Lingyue Yan et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder with a low survival rate. Pulmonary fibrosis is one of the complications of COVID-19 and has a high prevalence in COVID-19 patients. Currently, no effective therapies other than...
Minh Ngoc Le,Tuan Anh Nguyen
Minh Ngoc Le
IL-10 modified mRNA monotherapy prolongs survival after composite facial allografting through the induction of mixed chimerism [0.03%]
携带IL-10的修饰型mRNA单药治疗通过诱导混合嵌合体延长复合脸移植后的生存期
Ana Elena Aviña,Dante De Paz,Shu-Chun Huang et al.
Ana Elena Aviña et al.
Vascularized composite allotransplantation has great potential in face transplantation by supporting functional restoration following tissue grafting. However, the need for lifelong administration of immunosuppressive drugs still limits its...