Self-replicating RNA nanoparticle vaccine elicits protective immune responses against SARS-CoV-2 [0.03%]
自我复制型RNA纳米颗粒疫苗可激发针对SARS-CoV-2的保护性免疫反应
Guibin Lin,Huan Yan,Jing Sun et al.
Guibin Lin et al.
The creation of safe and effective vaccines that induce potent cellular and humoral immune responses against SARS-CoV-2 is urgently needed to end the global COVID-19 epidemic. Here, we developed an alphavirus-derived self-replicating RNA (r...
Landscape and significance of human super enhancer-driven core transcription regulatory circuitry [0.03%]
人类超级增强子驱动的核心转录调控线路的景观及其意义
Chenchen Feng,Chao Song,Yong Jiang et al.
Chenchen Feng et al.
A core transcription regulatory circuitry (CRC) is an interconnected self-regulatory circuitry that is formed by a group of core transcription factors (TFs). These core TFs collectively regulate gene expression by binding not only to their ...
Lihua Xie,Xiaolin Zhong,Wenyu Cao et al.
Lihua Xie et al.
In the early stage, N4-acetylcytidine (ac4C) was regarded as a conservative nucleoside present on tRNA and rRNA. Recently, studies have shown that ac4C also exists in human and yeast mRNA. N-Acetyltransferase-like protein 10 (NAT10) is the ...
MicroRNA-nanoparticles against cancer: Opportunities and challenges for personalized medicine [0.03%]
微RNA-纳米颗粒抗肿瘤治疗：个性化医疗的机会与挑战
Elisa Martino,Nunzia D&#x;Onofrio,Camilla Anastasio et al.
Elisa Martino et al.
Micro-RNAs (miRNAs) control gene expression at the post-transcriptional level and are widely involved in carcinogenesis, playing a role as both oncogenes and tumor suppressors. MiRNAs act as potent therapeutic weapon in cancer, but their po...
miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYC [0.03%]
miR-342-5p下游的Notch通过抑制MYC增强内皮细胞在剪切应力作用下的动脉转变
Xiaoyan Zhang,Jiaxing Sun,Peiran Zhang et al.
Xiaoyan Zhang et al.
During vascular development, endothelial cells (ECs) undergo arterialization in response to genetic programs and shear stress-triggered mechanotransduction, forming a stable vasculature. Although the Notch receptor is known to sense shear s...
Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells [0.03%]
用于CAR-T细胞的诱导型转激活因子药物： lentiviral载体的用途
María Tristán-Manzano,Noelia Maldonado-Pérez,Pedro Justicia-Lirio et al.
María Tristán-Manzano et al.
Controlling transgene expression through an externally administered inductor is envisioned as a potent strategy to improve safety and efficacy of gene therapy approaches. Generally, inducible ON systems require a chimeric transcription fact...
Identification of shared characteristics in tumor-infiltrating T cells across 15 cancers [0.03%]
基于15种癌症类型的肿瘤浸润性T细胞的特征识别
Xiyun Jin,Yideng Cai,Guangfu Xue et al.
Xiyun Jin et al.
Tumor-infiltrating T cells are essential players in tumor immunotherapy. Great progress has been achieved in the investigation of T cell heterogeneity. However, little is well known about the shared characteristics of tumor-infiltrating T c...