Improved gene therapy for MFRP deficiency-mediated retinal degeneration by knocking down endogenous bicistronic Mfrp and Ctrp5 transcript [0.03%]
通过敲低内源性双顺反子Mfrp和Ctrp5转录物改善MFRP缺乏介导的视网膜退行性疾病基因治疗
Xiao Tian,Qingyun Zheng,Jinyan Xie et al.
Xiao Tian et al.
The membrane frizzled-related protein (Mfrp) and C1-tumor necrosis factor related protein 5 (Ctrp5) genes are transcribed as a bicistronic unit and dysregulation of either gene is associated with retinal degeneration in the retinal pigment ...
Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches [0.03%]
慢性伤口愈合中外泌体生物载体的产生和递送机制研究
Garima,Deepika Sharma,Arun Kumar et al.
Garima et al.
Chronic wounds remain an unresolved medical issue because of major social and therapeutic repercussions that require extensive focus. Recent related theragnostic focuses only on wound management and is not effectively promoting chronic woun...
704/DNA vaccines leverage cytoplasmic DNA stimulation to promote anti-HIV neutralizing antibody production in mice and strong immune response against alpha-fetoprotein in non-human primates [0.03%]
DNA疫苗通过胞质DNA刺激促进小鼠中和HIV抗体的产生及在非人灵长类动物中针对AFP的免疫应答
Thibault Colombani,Thomas Haudebourg,Bruno Pitard
Thibault Colombani
Genetic immunization is an attractive approach for prophylactic and therapeutic vaccination using synthetic vectors to deliver antigen-encoding nucleic acids. Recently, DNA delivered by a physical means or RNA by liposomes consisting of fou...
Modified ASO conjugates encapsulated with cytidinyl/cationic lipids exhibit more potent and longer-lasting anti-HCC effects [0.03%]
新型ASO衍生物高效抑制肝癌生长与转移
Yufei Pan,Jing Guan,Yujing Gao et al.
Yufei Pan et al.
Antisense oligonucleotides (ASOs) are a class of therapeutics targeting mRNAs or genes that have attracted much attention. However, effective delivery and optimal accumulation in target tissues in vivo are still challenging issues. CT102 is...
GraphCPIs: A novel graph-based computational model for potential compound-protein interactions [0.03%]
基于图的潜在化合物-蛋白质相互作用的新型计算模型 GraphCPIs
Zhan-Heng Chen,Bo-Wei Zhao,Jian-Qiang Li et al.
Zhan-Heng Chen et al.
Identifying proteins that interact with drug compounds has been recognized as an important part in the process of drug discovery. Despite extensive efforts that have been invested in predicting compound-protein interactions (CPIs), existing...
Combination of protein and cell internalization SELEX identifies a potential RNA therapeutic and delivery platform to treat EphA2-expressing tumors [0.03%]
蛋白质和细胞内化SELEX的结合鉴定出了一种潜在的RNA治疗和输送平台以治疗EphA2表达肿瘤
Laura Santana-Viera,Justin P Dassie,Marta Rosàs-Lapeña et al.
Laura Santana-Viera et al.
The EphA2 receptor tyrosine kinase is overexpressed in most solid tumors and acts as the major driver of tumorigenesis. In this study, we developed a novel approach for targeting the EphA2 receptor using a 2'-fluoro-modified pyrimidine RNA ...
Silencing of microRNA-106b-5p prevents doxorubicin-mediated cardiotoxicity through modulation of the PR55α/YY1/sST2 signaling axis [0.03%]
microRNA-106b-5p沉默通过调节PR55α/YY1/sST2信号轴防止多柔比星介导的心脏毒性
Antonio Lax,Fernando Soler,Maria Josefa Fernandez Del Palacio et al.
Antonio Lax et al.
Clinical use of doxorubicin (Dox), an anthracycline with potent anti-tumor effects, is limited because of its highly chemotherapy-induced cardiotoxicity (CIC). After myocardial infarction (MI), we have recently identified Yin Yang-1 (YY1) a...
PPFIA1- targeting miR-181a mimic and saRNA overcome imatinib resistance in BCR-ABL1-independent chronic myeloid leukemia by suppressing leukemia stem cell regeneration [0.03%]
针对非BCR-ABL1依赖的慢性髓性白血病，miR-181a模拟物和saRNA通过抑制白血病干细胞再生来克服伊马替尼耐药性研究
Rui Su,Chuting Li,Xiuyuan Wang et al.
Rui Su et al.
A large proportion of patients with chronic myeloid leukemia (CML; 20%-50%) develop resistance to imatinib in a BCR-ABL1-independent manner. Therefore, new therapeutic strategies for use in this subset of imatinib-resistant CML patients are...
Circulating ECVs prevent neurodegeneration and preserve neuronal function in a model of preclinical intracerebral hemorrhage [0.03%]
循环工程条件外囊保护脑出血前期模型中的神经元免于变性并维持其功能
Annette Burkhart,Torben Moos
Annette Burkhart
Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies [0.03%]
编辑HPFH缺失突变的中心区域可改变胎儿血红蛋白和成人血红蛋白表达以治疗β型地中海贫血症
Vigneshwaran Venkatesan,Abisha Crystal Christopher,Manuel Rhiel et al.
Vigneshwaran Venkatesan et al.
Reactivation of fetal hemoglobin (HbF) is a commonly adapted strategy to ameliorate β-hemoglobinopathies. However, the continued production of defective adult hemoglobin (HbA) limits HbF tetramer production affecting the therapeutic benefi...