MicroRNA-142a-3p regulates neurogenic skeletal muscle atrophy by targeting Mef2a [0.03%]
microRNA-142a-3p通过靶向Mef2a调节神经源性肌肉萎缩
Xinyi Gu,Shen Wang,Dongdong Li et al.
Xinyi Gu et al.
Peripheral nerve injury can lead to progressive muscle atrophy and poor motor function recovery, which is a difficult point of treatment, and the mechanism needs to be further explored. In previous studies, we found that miR-142a-3p was sig...
Restoration of functional PAX6 in aniridia patient iPSC-derived ocular tissue models using repurposed nonsense suppression drugs [0.03%]
利用再利用的无义抑制药物在源自aniridia患者诱导多能干细胞的ocular组织模型中恢复功能性PAX6蛋白质
Dulce Lima Cunha,Hajrah Sarkar,Jonathan Eintracht et al.
Dulce Lima Cunha et al.
Congenital aniridia is a rare, pan-ocular disease causing severe sight loss, with only symptomatic intervention offered to patients. Approximately 40% of aniridia patients present with heterozygous nonsense variants in PAX6, resulting in ha...
Epigenetic therapy: BBC1115, a novel BET inhibitor with broad antitumor activity [0.03%]
表观遗传治疗：BBC1115，一种新型BET抑制剂，具有广谱抗肿瘤活性
Pradeep Reddy Cingaram
Pradeep Reddy Cingaram
Asymmetric trichotomous partitioning overcomes dataset limitations in building machine learning models for predicting siRNA efficacy [0.03%]
不对称三分划分法可以克服数据集局限性以建立预测siRNA有效性的机器学习模型
Kathryn R Monopoli,Dmitry Korkin,Anastasia Khvorova
Kathryn R Monopoli
Chemically modified small interfering RNAs (siRNAs) are promising therapeutics guiding sequence-specific silencing of disease genes. Identifying chemically modified siRNA sequences that effectively silence target genes remains challenging. ...
Amu Gubu,Xueli Zhang,Aiping Lu et al.
Amu Gubu et al.
Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups, have been widely used in programmable bioengineering. Since nucleic acids are intrinsically hydrophilic, the hydrophobic groups endow nucleic acid ...
PPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit progression of hepatocellular carcinoma [0.03%]
ATF6下调PPM1H并通过去磷酸化p-RPS6KB1抑制肝癌进展
Xiaoshuang Yang,Jianting Guo,Wei Li et al.
Xiaoshuang Yang et al.
We have shown previously that polymorphism of activating transcription factor 6 (ATF6) is associated with susceptibility to hepatocellular carcinoma (HCC). Therefore, genes down-regulated by ATF6 might play a tumor-suppressing role. In the ...
Integrated multiomics analysis and machine learning refine molecular subtypes and prognosis for muscle-invasive urothelial cancer [0.03%]
整合多组学分析和机器学习可精确诊断肌层浸润性尿路上皮癌的分子亚型和预后
Guangdi Chu,Xiaoyu Ji,Yonghua Wang et al.
Guangdi Chu et al.
Muscle-invasive urothelial cancer (MUC), characterized by high aggressiveness and significant heterogeneity, is currently lacking highly precise individualized treatment options. We used a computational pipeline to synthesize multiomics dat...
Quantum computing on nucleic acid research: Approaching towards next-generation computing [0.03%]
核酸量子计算研究：向下一代计算迈进
Chiranjib Chakraborty,Manojit Bhattacharya,Kuldeep Dhama et al.
Chiranjib Chakraborty et al.
Angiotensin II mediates hypertensive cardiac fibrosis via an Erbb4-IR-dependent mechanism [0.03%]
血管紧张素II通过ErbB4-IR依赖性机制介导高血压性心脏纤维化
Jian-Chun Li,Jian Jia,Li Dong et al.
Jian-Chun Li et al.
Transforming growth factor β (TGF-β)/Smad3 plays a vital role in hypertensive cardiac fibrosis. The long non-coding RNA (lncRNA) Erbb4-IR is a novel Smad3-dependent lncRNA that mediates kidney fibrosis. However, the role of Erbb4-IR in hy...
Salvatore Oliviero
Salvatore Oliviero