Non-viral in vivo cytidine base editing in hepatocytes using focused ultrasound targeted microbubbles [0.03%]
利用聚焦超声靶向微气泡实现体内肝脏细胞非病毒胞苷编辑
Cynthia D Anderson,Jennifer Ataam Arthur,Yuan Zhang et al.
Cynthia D Anderson et al.
CRISPR-Cas9-based genome editing technologies, such as base editing, have the potential for clinical translation, but delivering nucleic acids into target cells in vivo is a major obstacle. Viral vectors are widely used but come with safety...
Leverage of nuclease-deficient CasX for preventing pathological angiogenesis [0.03%]
CasX无酶切活性变异体用于抗病理性血管生成的潜在应用研究
Haote Han,Yanhui Yang,Yunjuan Jiao et al.
Haote Han et al.
Gene editing with a CRISPR/Cas system is a novel potential strategy for treating human diseases. Pharmacological inhibition of phosphoinositide 3-kinase (PI3K) δ suppresses retinal angiogenesis in a mouse model of oxygen-induced retinopath...
Overexpression of the mitochondrial anti-viral signaling protein, MAVS, in cancers is associated with cell survival and inflammation [0.03%]
线粒体抗病毒信号蛋白MAVS在癌症中的过表达与细胞存活和炎症相关
Sweta Trishna,Avia Lavon,Anna Shteinfer-Kuzmine et al.
Sweta Trishna et al.
Mitochondrial anti-viral signaling protein (MAVS) plays an important role in host defense against viral infection via coordinating the activation of NF-κB and interferon regulatory factors. The mitochondrial-bound form of MAVS is essential...
Novel approaches to glaucomatous neurodegeneration, based on the integrated stress response [0.03%]
基于整合应激反应的青光眼神经退行性病变的新方法研究
Luciana B Chiarini,Hilda Petrs-Silva,Rafael Linden
Luciana B Chiarini
Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G [0.03%]
一种利用慢病毒载体表达融合抑制肽mC46和抗Vif的APOBEC3G来强力阻断HIV-1感染的方法
Krista A Delviks-Frankenberry,Chet R Ojha,Kip J Hermann et al.
Krista A Delviks-Frankenberry et al.
Gene therapy strategies that effectively inhibit HIV-1 replication are needed to reduce the requirement for lifelong antiviral therapy and potentially achieve a functional cure. We previously designed self-activating lentiviral vectors that...
Unveiling ATF6 and PPM1H signaling in hepatocellular carcinoma progression: From ER stress to tumor suppression [0.03%]
ATF6和PPM1H信号在肝细胞癌进展中的作用：从内质网应激到肿瘤抑制
Prajish Iyer,Shivangi Oberai,Brian Jiang et al.
Prajish Iyer et al.
Role of long non-coding RNAs in cancer: From subcellular localization to nanoparticle-mediated targeted regulation [0.03%]
长链非编码RNA在癌症中的作用：从细胞定位到纳米粒子介导的靶向调控
Chunfang Wei,Ya Xu,Qian Shen et al.
Chunfang Wei et al.
Long non-coding RNAs (lncRNAs) are a class of RNA transcripts more than 200 nucleotides in length that play crucial roles in cancer development and progression. With the rapid development of high-throughput sequencing technology, a consider...
Cancer kill code extension [0.03%]
癌症杀伤程序扩展
Marcus E Peter
Marcus E Peter
Disease modeling and gene correction of LGMDR21 iPSCs elucidates the role of POGLUT1 in skeletal muscle maintenance, regeneration, and the satellite cell niche [0.03%]
POGLUT1在骨骼肌维持、再生和卫星细胞生态位中的作用的LGMDR21 iPSC疾病建模和基因校正
Jose L Ortiz-Vitali,Jianbo Wu,Nasa Xu et al.
Jose L Ortiz-Vitali et al.
Autosomal recessive limb-girdle muscular dystrophy 21 (LGMDR21) is caused by pathogenic variants in protein O-glucosyltransferase 1 (POGLUT1), which is responsible for O-glucosylation of specific epidermal growth factor (EGF) repeats found ...
Insight into the regulatory mechanism of dynamic chromatin 3D interactions during cardiomyocyte differentiation in human [0.03%]
人类心肌细胞分化过程中动态染色体三维互作的调控机制研究
Hui Liu,Yingying Ma,Jiaxin Yu et al.
Hui Liu et al.
Cardiogenesis is an extremely complicated process involved with DNA regulatory elements, and trans factors regulate gene expression pattern spatiotemporally. Enhancers, as the well-known DNA elements, activate target gene expression by tran...