A single stereogenic center matters: Development of stereodefined anti-tau PMO-gapmers [0.03%]
单一手性中心的重要性：抗tau PMO-gapmers的立体定义开发
Suxiang Chen,Bal Hari Poudel,Rakesh Naduvile Veedu
Suxiang Chen
Erratum: FUBP3 enhances HIV-1 transcriptional activity and regulates immune response pathways in T cells [0.03%]
FUBP3增强HIV-1转录活性并调节T细胞中的免疫反应途径（勘误）
Quentin M R Gibaut,Chuan Li,Anqi Cheng et al.
Quentin M R Gibaut et al.
[This corrects the article DOI: 10.1016/j.omtn.2025.102525.]. © 2025 The Author(s).
Published Erratum
Molecular therapy. Nucleic acids. 2025 Apr 24;36(2):102544. DOI:10.1016/j.omtn.2025.102544 2025
Analytical approach for identification and mechanistic insights into mRNA-lipid adduct formation [0.03%]
mRNA脂质加合物的识别与机理研究的分析方法
Sebastien Peronin,Camille Malburet,Chamsan Daher-Hassan et al.
Sebastien Peronin et al.
Messenger ribonucleic acid (mRNA), a promising tool in vaccine and therapeutic development, is reliant on intact mRNA delivery into target cells. Given its susceptibility to degradation, ensuring its stability is crucial, necessitating rigo...
Epigenetic small molecule screening identifies a new HDACi compound for ameliorating Duchenne muscular dystrophy [0.03%]
表观遗传小分子筛选发现改善杜氏肌营养不良的新组蛋白去乙酰化抑制剂化合物
Ke&#x;ale W Louie,Eva H Hasegawa,Gist H Farr rd et al.
Ke&#x;ale W Louie et al.
Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease. There are currently few effective therapies to treat the disease, although many approaches are being pursued. Certain histone deacetylase inhibitors (HDACi) have...
Human opsin restoration by histone methylation using methyltransferase fusion protein SETD7-dCas9 [0.03%]
利用SETD7-dCas9甲基转移酶融合蛋白通过组蛋白甲基化修复人眼 opsins
Na Ly Tran,Yoo Eun Kang,Hyeyeon Jeong et al.
Na Ly Tran et al.
Epigenetic modulation enables precise gene regulation without altering DNA sequences. While histone acetylation has been widely utilized for gene activation, the therapeutic potential of histone methylation remains underexplored. In this st...
Molecular properties and intramolecular interactions of peptide-conjugated phosphorodiamidate morpholino oligonucleotides [0.03%]
肽连接磷酰二胺吗啉氧寡核苷酸的分子性质及分子内相互作用研究
Evgenii Kliuchnikov,Farkhad Maksudov,Daniel Pierson et al.
Evgenii Kliuchnikov et al.
We combined circular dichroism (CD) and viscosity measurements with molecular dynamics (MD) simulations and classification and regression approaches to machine learning to characterize solution structures of 22-mer, 25-mer, and 30-mer pepti...
Transcriptomic analysis reveals lung cancer and subtype-specific alternative splicing biomarkers regulated by RNA-binding proteins [0.03%]
转录组分析揭示了由RNA结合蛋白调控的肺癌和亚型特有的选择性剪接生物标志物
Yilei Liu,Chenxi Zhang,Youqi Zheng et al.
Yilei Liu et al.
Lung cancer is the leading cause of cancer-related death worldwide, and the complex molecular mechanisms underlying its development, particularly the role of alternative splicing (AS) in different subtypes, remain poorly understood. In this...
Morgan N Ogwo,Bhupender Sharma,Gunjan Goyal et al.
Morgan N Ogwo et al.
Parkinson's disease (PD) is a debilitating neurodegenerative condition. Synaptic dysfunctions are associated with the onset and progressive neurodegeneration exhibited in PD. Healthy, active synapses are a prerequisite for non-pathological ...
A series of precise and controllable base editors with split-TadA-8e [0.03%]
一系列可精控的碱基编辑器（具有拆分TadA-8e）
Jinxin Wang,Qingjing He,Yuqiang Zeng et al.
Jinxin Wang et al.
Adenine base editors (ABEs) enable efficient A-to-G base conversions in genomic DNA, serving as powerful tools for basic research and clinical disease treatment. TadA-8e with high processive and compatibility makes ABE8e to be the most wide...