mRNA vaccine based on high-frequency prevalent antigens provides broad protection against influenza B virus [0.03%]
基于高频率抗原的mRNA疫苗可为乙型流感病毒提供广谱保护
Ziqi Cheng,Yeqing Sun,Yunbo Bai et al.
Ziqi Cheng et al.
Influenza B virus (IBV) is a major pathogen affecting the human respiratory tract. B/Victoria is currently the only prevalent influenza B lineage as B/Yamagata has become increasingly rare. Existing influenza vaccines provide limited protec...
Molecular and imaging biomarker responses to brain mutant HTT lowering in a mouse model of Huntington disease [0.03%]
亨廷顿舞蹈病小鼠模型中脑部突变HTT降低的分子和影像学生物标志物反应
Nicholas S Caron,Jianjia Fan,Da Ma et al.
Nicholas S Caron et al.
Therapies targeting mutant huntingtin (mHTT) reduction in the brain hold promise as disease-modifying treatments for Huntington disease (HD), necessitating biomarkers that accurately reflect treatment response. We evaluated candidate molecu...
MicroRNA mapping of bronchial aspirate for molecular phenotyping and prognostication in patients on mechanical ventilation [0.03%]
支气管吸引物的微小核糖核酸谱型在机械通气患者的分子分型和预后中的应用
Marta Molinero,Iván D Benítez,Manel Perez-Pons et al.
Marta Molinero et al.
The application of microRNA (miRNA) profiling in respiratory biospecimens, particularly bronchial aspirate (BAS), remains underexplored. Here, we aimed to validate and refine miRNA quantification in BAS samples to establish its suitability ...
Dynamic regulation of NeuroD1 expression level by a novel viral construct during astrocyte-to-neuron reprogramming [0.03%]
新的病毒载体通过动态调节神经转录因子NeuroD1的表达水平促进星形胶质细胞重编程为功能性神经元细胞
Natalie Mseis-Jackson,Mei Jiang,Mehek Sharma et al.
Natalie Mseis-Jackson et al.
Astrocyte-to-neuron reprogramming presents a viable approach for regenerative medicine. The reprogramming factor NeuroD1 has demonstrated the capability of neuronal reprogramming with high efficiency and yet primarily glutamatergic neuronal...
Progress and prospect of minicircle as a minimized non-viral DNA vector in gene therapy and regenerative medicine [0.03%]
微创非病毒DNA载体-minicircle在基因治疗和再生医学中的进展与前景
Pegah Chanani,Naeimeh Rezaei,Kianoush Dormiani et al.
Pegah Chanani et al.
The ideal and reliable genetic treatment of human diseases relies on the use of an effective vector that does not trigger serious side effects such as immunogenicity and genotoxicity. In recent years, non-viral DNA vectors have gained signi...
Exploring exon excision as a therapeutic intervention strategy for the future treatment of ADGRV1- associated retinitis pigmentosa [0.03%]
探索外显子切除作为治疗ADGRV1相关视网膜色素变性的未来疗法策略
Merel Stemerdink,Lucija Malinar,Sanne Broekman et al.
Merel Stemerdink et al.
Given the lack of treatment options for ADGRV1-associated retinitis pigmentosa (RP), we evaluated exon excision as a potential therapeutic strategy. To enable careful selection of target exons, in silico analyses of the ADGRV1 protein domai...
Advancing CRISPR with deep learning: A comprehensive review of models and databases [0.03%]
基于深度学习的CRISPR研究进展：模型与数据库综述
Roghayyeh Alipanahi,Leila Safari,Alireza Khanteymoori
Roghayyeh Alipanahi
CRISPR is considered a powerful tool for targeted genome editing. However, off-target effects remain a significant challenge in the CRISPR field, hindering its broader clinical application. To enhance the development of gene-editing therapi...
Mechanosensitive calcium ion channels Piezo1: A therapeutic target in liver disease [0.03%]
机械敏感性钙离子通道Piezo1：肝病治疗的新靶点
Jiao Liu,Xueying Wang,Fang He et al.
Jiao Liu et al.
The liver is vital in the metabolism of proteins, cholesterol, and carbohydrates, as well as energy production. Liver diseases often develop insidiously, making early diagnosis difficult, and rapid disease progression is directly associated...
Measles and rubella: From global health challenges to advancements in molecular diagnostics in the elimination era [0.03%]
从全球卫生挑战到消除时代的分子诊断进展——麻疹和风疹
Shivani Sharma,Yuba Raj Pokharel
Shivani Sharma
Measles and rubella are highly contagious viral infections with significant public health implications, particularly in low- and middle-income countries. Despite the availability of effective vaccines, these diseases continue to cause perio...
Daniel Nielsen,Maria Victorova,Timothy R Mercer et al.
Daniel Nielsen et al.