Infection-sensing minigenome as a novel therapeutic approach against Ebola virus [0.03%]
检测感染的 miniature 基因组作为治疗埃博拉病毒的新方法
Lin Wang,Brady N Zell,Brian J Parrett et al.
Lin Wang et al.
We describe here a molecular therapy that uses the virus's own proteins to combat itself. In this approach, infection-sensing RNAs encoding therapeutic genes are flanked by viral promoters and packaging signals in negative-sense orientation...
Targeting rare splicing defects: Antisense oligonucleotides offer a therapeutic strategy in FRDA [0.03%]
针对罕见的剪接缺陷：反义寡核苷酸可作为治疗弗里德reich共济失调的策略
Laurie M C Kerkhof,Ronald A M Buijsen
Laurie M C Kerkhof
Alternative polyadenylation and splicing regulation in refractory juvenile dermatomyositis: CELF2 at the crossroads [0.03%]
CELF2在难治性青少年皮肌炎的可变多腺苷酸化及剪接调控中的作用
Riccardo Varrica,Laura Lentini
Riccardo Varrica
Cao Hua,Saima Aftab,Abdul Rahaman et al.
Cao Hua et al.
Cell-penetrating antibody enhances nuclear delivery of triplex-forming oligonucleotides targeting HER2-positive cancers [0.03%]
一种细胞穿透型抗体能增强三链体形成寡核苷酸对HER2阳性癌的靶向性及核内递送作用
Anthony Minnah,Nicole M García Tubéns,Adam Krysztofiak et al.
Anthony Minnah et al.
Nucleic acid therapies (NATs) such as triplex-forming oligonucleotides (TFOs) offer innovative cancer treatment options to selectively target amplified oncogenes, such as HER2. However, challenges in intracellular and nuclear delivery hinde...
miRNAs from mesenchymal-stem-cell-derived extracellular vesicles: Emerging players in regenerative medicine and disease therapy [0.03%]
间充质干细胞来源细胞外囊泡中的microRNA：再生医学和疾病治疗中新兴的参与者
Yasna Shahsavandi,Farina Banaeian,Morteza Jafarinia et al.
Yasna Shahsavandi et al.
Mesenchymal stem cells (MSCs) hold immense promise in regenerative medicine due to their unique capabilities, including differentiation into various cell types and paracrine signaling. Among their secretions, extracellular vesicles (EVs) pl...
A sweet barrier to gene silencing: Glucose metabolism interferes with antisense oligonucleotide therapy [0.03%]
一把双刃剑：糖代谢阻碍反义寡核苷酸疗法发挥功效
Shuangdi Duan,Weizhi Zhang,Haiming Cao
Shuangdi Duan
The biochemical function of bivalent aptamer assemblies against B cell markers CD19 and CD20 [0.03%]
靶向B细胞标记物CD19和CD20的二价适配体复合物的生化功能研究
Yilam Ng Cen,Nicole B Williams,Nicolás Di Siervi et al.
Yilam Ng Cen et al.
B cells, essential components of the adaptive immune system, are central to the pathology of B cell malignancies and autoimmune disorders. These cells can be specifically targeted using ligands that recognize B cell surface receptors such a...
Comprehensive web-based platform for advanced PCR design, genotyping, synthetic biology, molecular diagnostics, and sequence analysis [0.03%]
全面的基于Web的平台，用于先进的PCR设计、基因分型、合成生物学、分子诊断和序列分析
Ruslan Kalendar
Ruslan Kalendar
We present a comprehensive web-based platform that integrates a suite of molecular biology tools tailored for PCR-based applications. Key features include custom multiplex tiling PCR panel design for amplicon sequencing, loop-mediated isoth...
Exploring CRISPR-Cas: The transformative impact of gene editing in molecular biology [0.03%]
探索CRISPR-Cas：基因编辑在分子生物学中的变革性影响
Vivek Pandey,Shivani Sharma,Yuba Raj Pokharel
Vivek Pandey
This review traces the evolution of clustered regularly interspaced short palindromic repeats (CRISPR) technology from a prokaryotic immune mechanism to a versatile tool for precise genome engineering. We compare CRISPR with traditional gen...