Rabies lyssavirus phosphoprotein possesses RNA duplex-unwinding activities [0.03%]
狂犬病lyssavirus磷蛋白具有解开RNA二聚体的作用
Jingfang Mu,Caiqian Wang,Ting Shu et al.
Jingfang Mu et al.
Rabies lyssavirus (RABV) is a prototypical neurotropic virus that belongs to the Rhabdoviridae family and causes one of the most lethal zoonotic diseases. For RNA viruses, RNA-unwinding proteins such as helicases and RNA chaperones are cruc...
Exon-targeted U1 snRNA rescues splicing defects and ameliorates inherited optic neuropathy: A novel RNA-based treatment [0.03%]
靶向外显子的U1小核RNA可修复剪接缺陷并改善遗传性视神经病变：一种新型RNA治疗技术
Hongli Zhang,Xiaoyan Sun,Zhengyang Chen et al.
Hongli Zhang et al.
GalNAc-conjugated siRNA targeting C/EBPβ reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model [0.03%]
N-乙酰半乳糖胺连接的靶向C/EBPβ的siRNA通过逆转代谢紊乱和恢复肝脏稳态来治疗小鼠MASLD
Shirin Elizabeth Khorsandi,Daniel Vasconcelos,Roman Nicholas et al.
Shirin Elizabeth Khorsandi et al.
CCAAT/enhancer-binding protein beta (C/EBPβ) is a master regulator of hepatic metabolism, inflammation, and fibrosis, making it an attractive but underexploited target for metabolic dysfunction-associated steatotic liver disease (MASLD). H...
Selective silencing of expanded CAG repeats: Chemically modified siRNA advances RNA-based therapies for polyglutamine diseases [0.03%]
选择性沉默CAG重复序列：化学修饰的siRNA可促进多聚谷氨酰胺疾病的RNA疗法发展
Gijs-Jan Scholten,Jamie T Hyde,Ronald A M Buijsen
Gijs-Jan Scholten
N1MΨU-modified mRNA vaccines break the mold in fish by enhancing innate immune activation [0.03%]
N1MΨU修饰的mRNA疫苗通过增强先天性免疫激活打破鱼类疫苗的常规
Dean Porter,Luc Jouneau,Mathilde Peruzzi et al.
Dean Porter et al.
Messenger RNA (mRNA) vaccines have revolutionized immunization strategies in mammals, with chemical modifications such as N1-methyl-pseudouridine (N1MΨU) enhancing stability, translation, and reducing innate immune activation. However, the...
Troy von Beck,Dwight D Koeberl
Troy von Beck
A shift of paradigm, emerging role of miRNAs as therapeutic targets for complex disease [0.03%]
范式转换与microRNA作为复杂疾病治疗靶点的作用不容忽视
Anna Altieri,Alessandra Mastricci,Riccardo Panella
Anna Altieri
Howard Y Chang,Lorinda Chung,Mark M Davis et al.
Howard Y Chang et al.
Lipid self-assembling nanoparticles as a novel platform for mRNA-based vaccination [0.03%]
基于脂质纳米颗粒的mRNA疫苗技术平台研究进展
Arianna De Chiara,Valeria Nele,Alessia Angelillo et al.
Arianna De Chiara et al.
Synthetic messenger RNA (mRNA) formulated in lipid nanoparticles (mRNA-LNPs) is a promising candidate for next-generation gene therapy and genetic vaccines. However, mRNA-LNP formulations require low-temperature storage to ensure proper tra...
Knowledge-graph-enhanced multi-scale modeling for drug-drug interaction prediction [0.03%]
基于知识图的多尺度建模药物相互作用预测方法研究
Jing Chen,Qiang Deng,Peimeng Zhen et al.
Jing Chen et al.
Drug-drug interaction (DDI) prediction is crucial for understanding combined medication effects and preventing adverse reactions. Traditional machine learning methods rely on handcrafted features and lack generalization, while existing deep...