Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair [0.03%]
单细胞蛋白质组学揭示真皮鞘细胞在伤口修复中的双重特性
Bing Zhu,Yaojun Lu,Xinyue Kang et al.
Bing Zhu et al.
Wound healing is a dynamic process involving multiple cell types and signaling pathways. Dermal sheath cells (DSCs), residing surrounding hair follicles, play a critical role in tissue repair, yet their regulatory mechanisms remain unclear....
Treatment of Surgical Scars with Fractional Carbon Dioxide (CO2) Laser: A Randomized Controlled Trial [0.03%]
分数二氧化碳激光治疗手术疤痕的疗效：随机对照试验
Liang Chen,Han Xu,Qiu Yu Wang et al.
Liang Chen et al.
Object: The aim of this study was to compare the long-term effects of fractional carbon dioxide (CO2) laser treatment with traditional therapy on surgical scars by analyzing and comparing observational indicators. Approach: A randomized con...
Effects of a New Enzymatic Debrider (SN514-066b) on Eschar Protein Digestion, Burn Wound Debridement, and Healthy Skin Irritation [0.03%]
一种新型酶脱bridder(SN514-066b)对焦痂蛋白消化、烧伤创面脱bridment及健康皮肤刺激性的影响
Herbert B Slade,Barry T Reece,Nick D McCoy et al.
Herbert B Slade et al.
Objective: SN514 is a thermolysin-like enzyme under development as a debrider. Preclinical and non-clinical studies supported a first in human healthy volunteer study to predict the need for protection of periwound skin. Approach: Pharmacol...
Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat Accelerates Wound Healing in a Mouse Hind limb Lymphedema Model [0.03%]
缺氧诱导因子脯氨酰羟化酶抑制剂罗沙司他在小鼠后肢淋巴水肿模型中促进伤口愈合
Kosuke Ishikawa,Yoshitada Hoshino,Masayuki Osawa et al.
Kosuke Ishikawa et al.
Objective: Drugs regulating hypoxia-inducible factor (HIF)-1α have not been investigated for wound healing in lymphedema. Therefore, we examined the effects of drug modulation of HIF-1α activity for wound healing in our previously develop...
Skin Grafting [0.03%]
植皮术
Jyrki Vuola,Andrew Lindford
Jyrki Vuola
Significance: Although skin grafting is a basic surgical procedure, there are many sophisticated innovations that are used only by experienced surgeons. In-depth knowledge of new and old methods gives the opportunity to select the most appr...
Comparative Effectiveness of Amniotic and Chorionic Grafts in the Treatment of Lower-Extremity Diabetic Ulcers Using U.S. Medicare Real-World Evidence (2018-2022): A Retrospective Observational Cohort [0.03%]
基于美国Medicare真实世界证据（2018-2022）比较胎盘间充质干细胞凝胶和异体宫血干细胞凝胶治疗下肢糖尿病溃疡的疗效：一项回顾性队列研究
William V Padula,Swetha Ramanathan,Benjamin G Cohen et al.
William V Padula et al.
Objective: Lower-extremity diabetic ulcers (LEDUs) affect more than 500,000 U.S. Medicare beneficiaries each year. Dehydrated human amnionic and chorionic allografts (DHACAs) are clinically effective complements to standard of care (SoC; e....
Acellular Adipose Matrices Seem to Be an Effective and Safe Strategy for Soft Tissue Regeneration and Volume Restoration: A Systematic Review of Clinically Relevant Literature [0.03%]
脱细胞脂肪基质似乎是一种有效且安全的软组织再生和体积恢复策略：临床相关文献系统性回顾
Manaav K S Mehta,Hanna E Englander,Ajay Rao et al.
Manaav K S Mehta et al.
Significance: Autologous adipose tissue grafting (AAG) can provide soft tissue reconstruction in congenital defects, traumatic injuries, cancer care, or cosmetic procedures; over 94,000 AAG procedures are performed in the United States ever...
Smoking Status Impacts Mitochondrial Function and Synthetic Function in Mesenchymal Stem Cells Derived from Diabetics with Arterial Insufficiency [0.03%]
吸烟状况影响糖尿病动脉缺血患者间充质干细胞的线粒体功能和合成功能
Dylan McLaughlin,Maiko Sasaki,Carson Hoffmann et al.
Dylan McLaughlin et al.
Objective: Diabetes and smoking are frequently co-morbid conditions leading to arterial insufficiency, significantly increasing the risk of non-healing wounds and subsequent major amputation. Autologous patient-specific mesenchymal stem cel...
HMGB1 Accelerates Wound Healing by Promoting the Differentiation of Epidermal Stem Cells via the "HMGB1-TLR4-Wnt/Notch" Axis [0.03%]
HMGB1通过"HMGB1-TLR4-Wnt/Notch"轴促进表皮干细胞分化从而加速伤口愈合作用的研究
Miao Zhen,Yongkang Zhu,Peng Wang et al.
Miao Zhen et al.
Objective: Impairments in the differentiation and migratory capacity of epidermal stem cells (ESCs) are pivotal factors contributing to delayed wound healing. High mobility group box1 (HMGB1) has recently emerged as a potential target for t...