Reimagining VEGF Therapy: The Role of PLCγ2 in Pan-Organ Endothelial Networks [0.03%]
从头开始想象VEGF疗法：PLCγ2在泛器官内皮网络中的作用
Ahmed S Abouhashem,Sumit S Verma,Julie Faden-McCormack et al.
Ahmed S Abouhashem et al.
Objective: Ischemic tissue perfusion remains a major clinical challenge despite VEGF's central role in angiogenesis. Limited success of VEGF-based therapies underscores the need to understand endothelial heterogeneity, as...
Benchmarking Zero-Shot Generative Pre-Trained Transformer-Based Multimodal Large Language Models for Pressure Injury Staging [0.03%]
基准测试基于生成性预训练变压器的压力损伤分期多模态大型语言模型的零样本性能
Toshiaki Takahashi,Kengo Miyo,Nao Tamai
Toshiaki Takahashi
Objective: To benchmark zero-shot generative pre-trained transformer (GPT)-based multimodal large language models (MLLMs) for pressure injury (PI) staging from photographs and quantify the effects of prompt strategy, stru...
Does Warmed Saline Irrigation Improve Comfort During Dressing Changes After Digit Replantation? A Randomized Controlled Trial [0.03%]
复温盐水冲洗可改善指尖再植术后更换敷料的舒适度吗？一项随机对照试验
Fengxia Lai,Feng Huang,Yunyi Sheng et al.
Fengxia Lai et al.
Objective: Dressing changes after digit replantation can trigger pain, anxiety, and local wound cooling, yet the clinical impact of cleansing solution temperature remains unclear. This study evaluated whether warmed salin...
Adult Burn Survivors Face Elevated Long-Term Risk of Major Adverse Cardiovascular Events, Venous Thromboembolism, and Mortality: A Real-World Analysis [0.03%]
成人烧伤幸存者长期患重大心血管疾病、静脉血栓栓塞和死亡的风险增加：现实世界分析
Yu-Hsiang Lin,Yu-Ching Wang,Tai-Li Chen et al.
Yu-Hsiang Lin et al.
Objective: Burn injuries affect millions globally, with increasing survival rates due to advances in acute care. However, long-term cardiovascular outcomes including major adverse cardiovascular events (MACE), venous thro...
Management of Infected Wounds: A Wound Healing Foundation Consensus Statement [0.03%]
感染性创面的处理：伤口愈合基金会共识声明
Nicolás Cortés-Penfield,Benjamin A Lipsky,Elof Eriksson et al.
Nicolás Cortés-Penfield et al.
The Wound Healing Foundation (WHF) previously organized consensus panels on the management of chronic wounds (2022), acute wounds (2024), and diabetic wounds (2025). This WHF consensus statement, authored by a global interdisciplinary panel...
Predicting Harm: A Systematic Review of Pediatric Pressure Injury Models and Their Clinical Shortcomings [0.03%]
预测压力性损伤的模型及其临床不足的系统综述——儿童视角
Xiaojie Zhang,Zhichao Yang,Xiuping Li et al.
Xiaojie Zhang et al.
Significance: Pediatric pressure injuries (PIs) are a distinct and preventable clinical challenge, yet risk prediction models tailored to children remain underdeveloped. This systematic review critically evaluates existin...
Development and Validation of a Novel Risk Prediction Model for Incident Diabetic Foot Complications: A Large, Longitudinal, Population-Based Machine Learning Study [0.03%]
新型糖尿病足并发症发生率预测模型的开发和验证：一项大规模纵向人群机器学习研究
Ziyun Li,Aomingyang Wang,Ruilin Wang et al.
Ziyun Li et al.
Objective: Diabetic foot complications (DFCs) are common diabetes complications. Existing tools for predicting incident DFCs remain insufficient. This study aimed to develop and validate a novel machine learning-based mod...
Diabetic Foot Ulcers as a Marker of Systemic Disease: Long-Term Survival, Limb Loss, and Economic Impact in a Large Real-World Cohort [0.03%]
糖尿病足溃疡作为系统性疾病标志的长期生存、截肢和经济影响现实世界队列研究
María Lourdes Del Río-Solá,Carlos García Padrón,Clara de la Torre Casaseca et al.
María Lourdes Del Río-Solá et al.
Background: Diabetic foot ulcers (DFUs) represent one of the most severe complications of diabetes mellitus and are associated with limb loss, excess mortality, and substantial health care costs. Although DFUs are often a...
Temporal In Vitro Models of Skin Wound Healing Components: A Cell-Specific Framework for Acute and Chronic Repair Mechanisms [0.03%]
皮肤伤口愈合成分的时空体外模型：急性期和慢性期修复机制的细胞特异性框架
Dipti Kalshetti,Mahmud Amin,Ridham Varsani et al.
Dipti Kalshetti et al.
Significance: Wound healing is as much about opportunity (Gk. Karios) and sequence (Gk. Chronos). The sequential healing responses involve concerted responses of cells of various lineages along with both soluble (cytokine...
The Diabetic Foot Consortium Biomarker Platform Study: A New Approach to Advance Diabetic Foot Ulcer Healing [0.03%]
糖尿病足联盟生物标志物平台研究：促进糖尿病足溃疡愈合的新方法
Brian M Schmidt,Cathie Spino,Teresa L Z Jones et al.
Brian M Schmidt et al.
Objective: Platform studies are an innovative clinical trial design to evaluate multiple potential therapies simultaneously using a master protocol framework for more rapid discovery of critical new disease-modifying ther...