Fisetin-Mediated Topical Modulation of Senescent Cells in Skin Improves Wound Healing Dynamics in Diabetic Mice [0.03%]
fisetin改善糖尿病小鼠皮肤老化细胞及伤口愈合效果的研究
Asfia Numani,Margarita Carrasco-Jeldres,Barbara Hernandez-Rovira et al.
Asfia Numani et al.
Objective: Diabetes mellitus affects over 25% of adults aged 65+ in the United States and is associated with a heightened risk of developing diabetic foot ulcers. Accumulation of senescent cells within the wound microenvi...
Frailty Predicts Postoperative Complications in Patients Undergoing Surgery for Diabetic Foot Ulcers [0.03%]
衰弱对糖尿病足溃疡患者的手术预后影响研究
Felix J Klimitz,Samuel Knoedler,Tobias Niederegger et al.
Felix J Klimitz et al.
Objective: To determine whether frailty, as quantified using the Five-Item Modified Frailty Index (mFI-5), independently predicts postoperative complications in patients undergoing surgery for diabetic foot ulcers (DFUs),...
Integrating Regenerative Therapies and Artificial Intelligence for Precision Management of Diabetic Foot Ulcers [0.03%]
再生疗法与人工智能在糖尿病足溃疡精准治疗中的应用整合研究
Hsiu-Jung Liao,Tzu-Chi Liao,Yu-Feng Wu
Hsiu-Jung Liao
Significance: Diabetic foot ulcers (DFUs) represent one of the most devastating complications of diabetes, leading to high rates of amputation and mortality. Their multifactorial pathogenesis-including neuropathy, ischemi...
In Vivo, Label-Free Multiphoton Microscopy Is Sensitive to Altered Metabolism and Structure in Aged Skin [0.03%]
体内无标签多光子显微镜技术可用于检测老化皮肤的代谢和结构变化
Marcos R Rodriguez,Alan E Woessner,Kyle P Quinn
Marcos R Rodriguez
Objective: The expected increase in age-related health care costs over the coming decades underscores the need to characterize the effects of biological aging in our cells and tissues. Our objective is to use in vivo mult...
Efficacy and Safety of Human Amniotic Membrane for Chronic Wounds: A Systematic Review and Meta-Analysis of Clinical Trials [0.03%]
人羊膜治疗慢性难愈合创面的疗效和安全性系统评价和 meta 分析
Chengcheng Zheng,Weiwei Tang,Xingwu Ran
Chengcheng Zheng
Objective: The meta-analysis was performed to evaluate the efficacy and safety associated with the application of human amniotic membrane (HAM) in individuals with chronic nonhealing wounds. ...
Immune Imbalance Drives Keloid Pathogenesis: Emerging Targets for Precision Immunotherapy [0.03%]
免疫失衡驱动瘢痕过度增生的机制及精确诊疗靶点
Qilei Chen,Shujun Wan,Yuanyuan Duan et al.
Qilei Chen et al.
Significance: Keloids represent a persistent clinical challenge, with recurrence rates approaching 100% after conventional surgical excision. Historically viewed as fibroblast-driven scars, emerging evidence positions imm...
Efficacy of a Novel Daily-Use Hydrocolloid Pad on Wound Healing: Findings of a 16-Day, Single-Center, Randomized, Controlled Study [0.03%]
新型每日使用的水胶体敷料对伤口愈合疗效的临床研究：一项为期16天的单中心随机对照试验
Jenny Du-Soriano,Diana Friscia,Robert S Kirsner
Jenny Du-Soriano
Objective: To evaluate wound healing with a novel bandage with hydrocolloid pad designed for daily use/replacement in a new model of laser-induced burns/wounds. Approach: In this randomized, controlled, single-center, 16-day study, healthy ...
Dual-Action Topical Therapy Accelerates Healing of MRSA-Infected Burn Wounds by Targeting Infection and Inflammation [0.03%]
一种兼具抗菌和抗炎作用的局部烧伤创面感染治疗手段可加速MRSA感染性难愈合创面的修复
Miaoqing Xiang,Zongze Yao,Wei Shao et al.
Miaoqing Xiang et al.
Objective: Burn injuries affect over 11 million people annually, and methicillin-resistant Staphylococcus aureus (MRSA) infection significantly delays healing by sustaining inflammation and promoting scarring. This study evaluated N-benzyl ...
Shawn Jeffrey Loder,J Peter Rubin
Shawn Jeffrey Loder
Significance: Wound healing is a complex process, and while the epidermis and dermis receive significant attention, the role of the hypodermis is important. The adipose-rich hypodermis or subcutaneous layer supports overall skin function, a...
Comparison of "Semiocclusive Dressing" Treatment Using Plastic Wrap or Low-Adherent Absorbent Wound Dressings Versus Occlusive Dressing Treatment for Stage II Pressure Injuries: A Randomized, Controlled, Noninferiority Trial [0.03%]
塑料薄膜与低粘性吸水性敷料作为半封闭敷料治疗II期压力性损伤与完全封闭式敷料的比较：随机对照非劣效性试验
Jun Takahashi,Kayoko Nakae,Osamu Yokota et al.
Jun Takahashi et al.
Objective: To verify the noninferiority of the effectiveness of "semiocclusive dressing" (SOD) treatment using plastic wrap or low-adherent absorbent wound dressings compared with occlusive dressing (OD) treatment for National Pressure Inju...