Temporal In Vitro Models of Skin Wound Healing Components: A Cell-Specific Framework for Acute and Chronic Repair Mechanisms [0.03%]
皮肤伤口愈合成分的时空体外模型：急性期和慢性期修复机制的细胞特异性框架
Dipti Kalshetti,Mahmud Amin,Ridham Varsani et al.
Dipti Kalshetti et al.
Significance: Wound healing is as much about opportunity (Gk. Karios) and sequence (Gk. Chronos). The sequential healing responses involve concerted responses of cells of various lineages along with both soluble (cytokine...
The Diabetic Foot Consortium Biomarker Platform Study: A New Approach to Advance Diabetic Foot Ulcer Healing [0.03%]
糖尿病足联盟生物标志物平台研究：促进糖尿病足溃疡愈合的新方法
Brian M Schmidt,Cathie Spino,Teresa L Z Jones et al.
Brian M Schmidt et al.
Objective: Platform studies are an innovative clinical trial design to evaluate multiple potential therapies simultaneously using a master protocol framework for more rapid discovery of critical new disease-modifying ther...
The Functionality of High-Density Lipoproteins Is Impaired in People with Diabetes Who Require Minor Amputations [0.03%]
糖尿病合并需要小截肢患者的高密度脂蛋白功能受损
Zahra Lotfollahi,Emma L Solly,Joanne T M Tan et al.
Zahra Lotfollahi et al.
Objective: High-density lipoprotein (HDL) functionality is emerging as a novel predictor of disease outcomes. The role of HDL functionality in patients with diabetes-related amputations is unexplored. We aimed to assess c...
Protein-Based Nutrition for Chronic Wounds: A Clinician's Guide to Patient Selection, Dosing, Monitoring, and Outcomes [0.03%]
基于蛋白的营养素在慢性伤口治疗中的应用——临床医师选择患者、用药剂量、监测及预后的指导手册
Zilong Tan,Yi Ru,Caiyun Zhang et al.
Zilong Tan et al.
Significance: Chronic wounds remain a major global health burden and often stall despite guideline-based care because of persistent inflammation, oxidative stress, impaired perfusion, and dysregulated extracellular matrix...
Overcoming Challenges in Wound Infection: Biofilm and Antimicrobial Resistance [0.03%]
应对伤口感染的挑战：生物膜与抗菌药物耐药性
Markus Rothmaier,Matthew J Hardman,Bithi Chatterjee et al.
Markus Rothmaier et al.
Significance: Chronic wounds represent a growing clinical and economic burden, affecting 1-2% of the global population, with prevalence expected to rise due to aging and increasing rates of diabetes, obesity, and vascular...
Partnering with Communities to Improve Diabetic Foot Ulcer Care in High-Risk Populations [0.03%]
与社区合作改善高风险人群糖尿病足溃疡护理
Nancy Gauvin,Breana Wayne,Shomita S Mathew-Steiner et al.
Nancy Gauvin et al.
Background: Diabetic foot ulcers (DFUs) remain one of the most devastating complications of diabetes, accounting for over 80% of nontraumatic amputations and contributing to a 5-year mortality rate exceeding 30%. Despite ...
Maria Shvedova,Minsung Cho,Jeroen Eyckmans et al.
Maria Shvedova et al.
Significance: Chronic wounds such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers are characterized by impaired healing and persistent inflammation. Cellular senescence, defined as irreversible growth arre...
Hanqi Yao,Michelle F Griffin,Serena L Jing et al.
Hanqi Yao et al.
Significance: Wound healing is an energetically demanding process that is easily disturbed by metabolic dysregulation. Metabolic dysregulation, induced by diabetes, obesity, insulin resistance, and various hormone imbalan...
Engineered Mesenchymal Stem Cells with Endogenous Trehalose Expression Activate the NRF2-HMOX1 Pathway to Enhance Antioxidant Stress and Wound Healing Capacity [0.03%]
内源性海藻糖表达的工程间充质干细胞通过激活NRF2-HMOX1途径增强抗氧化应激和促进伤口愈合能力
Zhen Wang,Xin Liu,Xin Chen et al.
Zhen Wang et al.
Objective: Oxidative stress limits mesenchymal stem cell (MSC) efficacy in tissue repair by reducing retention and survival at injury sites. Endogenous production of trehalose may enhance MSC resilience and promote skin w...
The Invisible Wound: Silent Focal Breach of Skin Integrity that Cascades into Systemic Dysfunction and Chronic Morbidity [0.03%]
无形的伤口：沉默的重点违背导致皮肤完整性受损并进而引发全身功能障碍和慢性疾病的连锁反应
Chandan K Sen,Sashwati Roy
Chandan K Sen
Barrier function of human skin maintains hydration by preventing excessive transepidermal water loss (TEWL), blocks the entry of pathogens and allergens, regulates thermal and chemical exchange with the environment, and sustains immune equi...