Carole A Oskeritzian
Carole A Oskeritzian
Background: Mast cells (MC) are ubiquitous resident cells, traditionally viewed as effector cells of allergic reactions that can store and synthesize de novo many mediators upon activation by a variety of stimuli. Excitin...
Wound Healing Angiogenesis: Innovations and Challenges in Acute and Chronic Wound Healing [0.03%]
创伤愈合血管生成：急性期和慢性期伤口愈合的创新与挑战
Tatiana N Demidova-Rice,Jennifer T Durham,Ira M Herman
Tatiana N Demidova-Rice
Background: Formation of new blood vessels, by either angiogenesis or vasculogenesis, is critical for normal wound healing. Major processes in neovascularization include (i) growth-promoting or survival factors, (ii) prot...
Christopher J Ferrante,Samuel Joseph Leibovich
Christopher J Ferrante
Background: Macrophages (Mφs) participate in wound healing by coordinating inflammatory and angiogenic processes. Mφs respond to environmental cues by adopting either "classically" activated (M1) proinflammatory or "alt...
H Paul Ehrlich,Thomas K Hunt
H Paul Ehrlich
Background: Open wound closure by wound contraction produces a healed defect made up mostly of dermis. Generating thicker collagen fibers condenses granulation tissue, which pulls surrounding skin into the defect. ...