The Contribution of Peroxisome Proliferator-Activated Receptor Gamma to Cutaneous Wound Healing [0.03%]
过量生成激活γ受体对皮肤伤口愈合的贡献
Andrew Leask
Andrew Leask
Significance: Cutaneous tissue repair involves an initial inflammatory phase, followed by a fibroproliferative phase and finally by a resolution phase. Failure to initiate fibroblast recruitment during the fibroproliferat...
Free Tissue Transfer for Limb Salvage in High-Risk Patients: Worth the Risk [0.03%]
高风险患者保肢的游离组织移植：冒险一试值得吗？
Matthew Endara,Ivica Ducic,Christopher Attinger
Matthew Endara
Significance: Mircosurgical free tissue transfer is a powerful tool in the arsenal of reconstructive surgeons, oftentimes as the final option in limb salvage before amputation. Patients presenting for limb salvage frequen...
A Connexin43 Mimetic Peptide Promotes Regenerative Healing and Improves Mechanical Properties in Skin and Heart [0.03%]
一种Connexin43模拟肽促进皮肤和心脏修复性愈合并改善机械性能
Emily L Ongstad,Michael P O&#x;Quinn,Gautam S Ghatnekar et al.
Emily L Ongstad et al.
Significance: Evidence is building that the gap junction protein connexin43 (Cx43) is an important molecule in regenerative healing of skin and heart. Excess scarring from skin wound healing is a continuing clinical probl...
Tero A H Järvinen,Erkki Ruoslahti
Tero A H Järvinen
Significance: The healing of injuries, such as those caused by ischemia (myocardial infarction, stroke), trauma, surgery, and inflammation, tends to happen through undesirable and harmful scarring. Current options in redu...
Sadanori Akita,Kozo Akino,Akiyoshi Hirano
Sadanori Akita
Significance: The benefit and role of basic fibroblast growth factor (bFGF) in scarless wound healing in clinical application and basic mechanism are discussed. bFGF is a glycoprotein which is widely used in treating woun...
David T Corr,David A Hart
David T Corr
Significance: Skin exhibits direction-dependent biomechanical behavior, influenced by the structural orientation of its collagen-rich fibrous network and its viscous ground-substance matrix. Injury can affect the skin's s...
Marissa Janine Carter
Marissa Janine Carter
Objective: To describe the role of health economics (HE) in wound care in relation to coverage and reimbursement. Approach: Narrative d...
Benjamin J Brown,Christopher E Attinger
Benjamin J Brown
Significance: A below-knee amputation (BKA) can be the most functional option for select patients with a diseased lower extremity and may offer a better quality of life than limb salvage in some patients. ...
Epidermal Growth Factor and Epidermal Growth Factor Receptor: The Yin and Yang in the Treatment of Cutaneous Wounds and Cancer [0.03%]
表皮生长因子和表皮生长因子受体在创面修复与肿瘤治疗中的双刃剑作用机制：阴阳相济，刚柔并举
Richard J Bodnar
Richard J Bodnar
Significance: Epidermal growth factor (EGF) and EGF receptor (EGFR) play an essential role in wound healing through stimulating epidermal and dermal regeneration. The development of new therapies for enhancing wound heali...
Daniel J Gibson,Gregory S Schultz
Daniel J Gibson
Significance: The process of wound healing includes the regulated destruction of proteins via enzymes called proteinases. However, when the proteolytic process becomes excessive, pro-healing factors are destroyed and the ...