A Paradigm of Fibroblast Activation and Dermal Wound Contraction to Guide the Development of Therapies for Chronic Wounds and Pathologic Scars [0.03%]
关于成纤维细胞活化和真皮创口收缩的范式以指导慢性伤口及病理性疤痕疗法的发展
Howard Levinson
Howard Levinson
Significance: Delayed wound healing and pathologic scarring are abnormal processes that can be thought of as occurring on a wound healing continuum, where insufficient wound contraction leads to nonhealing wounds, and ove...
Splinting Strategies to Overcome Confounding Wound Contraction in Experimental Animal Models [0.03%]
实验动物模型中克服伤口收缩的夹板策略
Jeffrey M Davidson,Fang Yu,Susan R Opalenik
Jeffrey M Davidson
Significance: Clinical healing by secondary intention frequently occurs in skin that is firmly anchored to underlying (human) connective tissue. Small animals (rodents) are extensively utilized to model human cutaneous wo...
Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention [0.03%]
肌成纤维细胞在伤口收缩、瘢痕和纤维化中的机械调节：新的治疗干预机会
Livingston Van De Water,Scott Varney,James J Tomasek
Livingston Van De Water
Significance: Myofibroblasts are responsible for wound closure that occurs in healed acute wounds. However, their actions can result in disfiguring scar contractures, compromised organ function, and a tumor promoting stro...
A Snapshot of Direct Cell-Cell Communications in Wound Healing and Scarring [0.03%]
伤口愈合和瘢痕形成过程中的细胞直接通讯研究进展
H Paul Ehrlich
H Paul Ehrlich
Significance: The repair of wounds usually terminates with a scar. The healing from a severe tissue loss can create a new clinical problem, excessive scarring. Approaches to prevent excessive scarring will optimize the re...
Biomechanics of the Diabetic Foot: Consideration in Limb Salvage [0.03%]
糖尿病足生物力学： limb salvage时的注意事项
Paul J Kim
Paul J Kim
Significance: The biomechanics of the diabetic foot is altered and maladaptive. We lack a thorough understanding of the functional consequences of limb salvage. We currently rely on observation and descriptive data pertai...
Biomaterial Scaffolds for Controlled, Localized Gene Delivery of Regenerative Factors [0.03%]
用于再生因子的可控和局部基因输送的生物材料支架
Robert Michael Gower,Lonnie D Shea
Robert Michael Gower
Significance: Biomaterials play central roles in tissue regeneration by maintaining a space for tissue growth and facilitating its integration with the host. The regenerative capacity of materials can be enhanced through ...
Christopher E Nelson,Mukesh Kumar Gupta,Elizabeth J Adolph et al.
Christopher E Nelson et al.
Significance: Aberrant overexpression of proinflammatory molecules is believed to be a key mediator in the formation of chronic skin wounds, and the inhibition of these signals may be an effective therapeutic strategy to ...
Golgi Feels Its Own Wound [0.03%]
高尔基体感受自身的创伤
Charbel Darido,Stephen M Jane
Charbel Darido
Significance: The Golgi apparatus is essential for protein processing, sorting, and transport. Processing includes carbohydrate modifications and proteolytic cleavage, and transport can involve secretion from the cell or ...
Mateusz S Wietecha,Luisa A DiPietro
Mateusz S Wietecha
Significance: Re-establishment of a functional vascular network is a critical component of successful wound repair. One of the most potent pro-angiogenic agents is vascular endothelial growth factor (VEGF), which, from a ...
The Yin and Yang of Integrin Function in Re-Epithelialization During Wound Healing [0.03%]
integrin在伤口愈合再上皮化过程中的阴阳两面性
Manuela Martins-Green
Manuela Martins-Green
Background: Integrins are transmembrane proteins that are present in the plasma membrane of basal ketatinocytes and connect them to the underlying basement membrane and to the dermis. There are primarily two types of inte...