Interactions of the Extracellular Matrix and Progenitor Cells in Cutaneous Wound Healing [0.03%]
表皮伤口愈合中细胞外基质与干细胞的相互作用
Susan W Volk,Syed Amir Iqbal,Ardeshir Bayat
Susan W Volk
Significance: Both chronic wounds and excessive scar formation after cutaneous injury create a formidable clinical problem resulting in considerable morbidity and healthcare expenditure. The deposition and remodeling of e...
Axolotl as a Model to Study Scarless Wound Healing in Vertebrates: Role of the Transforming Growth Factor Beta Signaling Pathway [0.03%]
墨西哥钝头螈作为研究脊椎动物无瘢痕伤口愈合的模型：转化生长因子β信号通路的作用
Jean-François Denis,Mathieu Lévesque,Simon D Tran et al.
Jean-François Denis et al.
Significance: The skin is our largest organ, with the primary role of protection against assaults from the outside world. It also suffers frequent damage, from minor scrapes to, more rarely, complete destruction such as i...
Focal Adhesion Kinase: A Key Mediator of Transforming Growth Factor Beta Signaling in Fibroblasts [0.03%]
肌纤维母细胞中黏着斑激酶是转化生长因子β信号通路的关键介质
Andrew Leask
Andrew Leask
Significance: There is no effective drug therapy for scarring and fibrotic disease. The cytokine transforming growth factor beta (TGF-β) promotes tissue repair, but its excessive action can lead to over exuberant scarrin...
Integrins as Modulators of Transforming Growth Factor Beta Signaling in Dermal Fibroblasts During Skin Regeneration After Injury [0.03%]
损伤后皮肤再生过程中表皮纤维细胞中整合素调节转化生长因子β信号转导的功能研究
Stellar Boo,Lina Dagnino
Stellar Boo
Significance: Abnormal wound repair results from disorders in granulation tissue remodeling, and can lead to hypertrophic scarring and fibrosis. Excessive scarring can compromise tissue function and decrease tissue resist...
Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing [0.03%]
转化生长因子β在伤口愈合不同阶段的关键作用
Mohammadreza Pakyari,Ali Farrokhi,Mohsen Khosravi Maharlooei et al.
Mohammadreza Pakyari et al.
Significance: This review highlights the critical role of transforming growth factor beta (TGF-β)1-3 within different phases of wound healing, in particular, late-stage wound healing. It is also very important to identif...
Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring [0.03%]
转化生长因子β信号转导在伤口愈合和瘢痕形成中的动态变化
Kenneth W Finnson,Sarah McLean,Gianni M Di Guglielmo et al.
Kenneth W Finnson et al.
Significance: Wound healing is an intricate biological process in which the skin, or any other tissue, repairs itself after injury. Normal wound healing relies on the appropriate levels of cytokines and growth factors to ...
Victor W Wong,Bill Beasley,John Zepeda et al.
Victor W Wong et al.
Objective: To mechanically control the wound environment and prevent cutaneous scar formation. Approach: We subjected various material ...
Rapid Fabrication of Living Tissue Models by Collagen Plastic Compression: Understanding Three-Dimensional Cell Matrix Repair In Vitro [0.03%]
快速制备活体组织模型的胶原塑料压缩法：体外理解三维细胞基质修复
Umber Cheema,Robert A Brown
Umber Cheema
Objective: To produce biomimetic collagen scaffolds for tissue modeling and as tissue-engineered implants. Approach: Control of collage...
Justin R Sharpe,Yella Martin
Justin R Sharpe
Significance: Scarring continues to present a significant clinical problem. Wound contraction leads to scarring and is mediated by myofibroblasts and contractile forces across the wound bed. Contracture formation can have...
Integrin β 1: A Mechanosignaling Sensor Essential for Connective Tissue Deposition by Fibroblasts [0.03%]
整合素β1：纤维母细胞合成结缔组织所需的机械信号传感器
Andrew Leask
Andrew Leask
Significance: There is no effective drug treatment for fibrosis (i.e., pathological scarring). Identifying the fundamental mechanisms responsible for normal and pathological connective tissue deposition is likely to yield...