Biomechanics of the Diabetic Foot: Consideration in Limb Salvage [0.03%]
糖尿病足生物力学： limb salvage时的注意事项
Paul J Kim
Paul J Kim
Significance: The biomechanics of the diabetic foot is altered and maladaptive. We lack a thorough understanding of the functional consequences of limb salvage. We currently rely on observation and descriptive data pertai...
Biomaterial Scaffolds for Controlled, Localized Gene Delivery of Regenerative Factors [0.03%]
用于再生因子的可控和局部基因输送的生物材料支架
Robert Michael Gower,Lonnie D Shea
Robert Michael Gower
Significance: Biomaterials play central roles in tissue regeneration by maintaining a space for tissue growth and facilitating its integration with the host. The regenerative capacity of materials can be enhanced through ...
Christopher E Nelson,Mukesh Kumar Gupta,Elizabeth J Adolph et al.
Christopher E Nelson et al.
Significance: Aberrant overexpression of proinflammatory molecules is believed to be a key mediator in the formation of chronic skin wounds, and the inhibition of these signals may be an effective therapeutic strategy to ...
Golgi Feels Its Own Wound [0.03%]
高尔基体感受自身的创伤
Charbel Darido,Stephen M Jane
Charbel Darido
Significance: The Golgi apparatus is essential for protein processing, sorting, and transport. Processing includes carbohydrate modifications and proteolytic cleavage, and transport can involve secretion from the cell or ...
Mateusz S Wietecha,Luisa A DiPietro
Mateusz S Wietecha
Significance: Re-establishment of a functional vascular network is a critical component of successful wound repair. One of the most potent pro-angiogenic agents is vascular endothelial growth factor (VEGF), which, from a ...
The Yin and Yang of Integrin Function in Re-Epithelialization During Wound Healing [0.03%]
integrin在伤口愈合再上皮化过程中的阴阳两面性
Manuela Martins-Green
Manuela Martins-Green
Background: Integrins are transmembrane proteins that are present in the plasma membrane of basal ketatinocytes and connect them to the underlying basement membrane and to the dermis. There are primarily two types of inte...
The Contribution of Peroxisome Proliferator-Activated Receptor Gamma to Cutaneous Wound Healing [0.03%]
过量生成激活γ受体对皮肤伤口愈合的贡献
Andrew Leask
Andrew Leask
Significance: Cutaneous tissue repair involves an initial inflammatory phase, followed by a fibroproliferative phase and finally by a resolution phase. Failure to initiate fibroblast recruitment during the fibroproliferat...
Free Tissue Transfer for Limb Salvage in High-Risk Patients: Worth the Risk [0.03%]
高风险患者保肢的游离组织移植：冒险一试值得吗？
Matthew Endara,Ivica Ducic,Christopher Attinger
Matthew Endara
Significance: Mircosurgical free tissue transfer is a powerful tool in the arsenal of reconstructive surgeons, oftentimes as the final option in limb salvage before amputation. Patients presenting for limb salvage frequen...
A Connexin43 Mimetic Peptide Promotes Regenerative Healing and Improves Mechanical Properties in Skin and Heart [0.03%]
一种Connexin43模拟肽促进皮肤和心脏修复性愈合并改善机械性能
Emily L Ongstad,Michael P O&#x;Quinn,Gautam S Ghatnekar et al.
Emily L Ongstad et al.
Significance: Evidence is building that the gap junction protein connexin43 (Cx43) is an important molecule in regenerative healing of skin and heart. Excess scarring from skin wound healing is a continuing clinical probl...
Tero A H Järvinen,Erkki Ruoslahti
Tero A H Järvinen
Significance: The healing of injuries, such as those caused by ischemia (myocardial infarction, stroke), trauma, surgery, and inflammation, tends to happen through undesirable and harmful scarring. Current options in redu...