Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing [0.03%]
转化生长因子β在伤口愈合不同阶段的关键作用
Mohammadreza Pakyari,Ali Farrokhi,Mohsen Khosravi Maharlooei et al.
Mohammadreza Pakyari et al.
Significance: This review highlights the critical role of transforming growth factor beta (TGF-β)1-3 within different phases of wound healing, in particular, late-stage wound healing. It is also very important to identif...
Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring [0.03%]
转化生长因子β信号转导在伤口愈合和瘢痕形成中的动态变化
Kenneth W Finnson,Sarah McLean,Gianni M Di Guglielmo et al.
Kenneth W Finnson et al.
Significance: Wound healing is an intricate biological process in which the skin, or any other tissue, repairs itself after injury. Normal wound healing relies on the appropriate levels of cytokines and growth factors to ...
Victor W Wong,Bill Beasley,John Zepeda et al.
Victor W Wong et al.
Objective: To mechanically control the wound environment and prevent cutaneous scar formation. Approach: We subjected various material ...
Rapid Fabrication of Living Tissue Models by Collagen Plastic Compression: Understanding Three-Dimensional Cell Matrix Repair In Vitro [0.03%]
快速制备活体组织模型的胶原塑料压缩法：体外理解三维细胞基质修复
Umber Cheema,Robert A Brown
Umber Cheema
Objective: To produce biomimetic collagen scaffolds for tissue modeling and as tissue-engineered implants. Approach: Control of collage...
Justin R Sharpe,Yella Martin
Justin R Sharpe
Significance: Scarring continues to present a significant clinical problem. Wound contraction leads to scarring and is mediated by myofibroblasts and contractile forces across the wound bed. Contracture formation can have...
Integrin β 1: A Mechanosignaling Sensor Essential for Connective Tissue Deposition by Fibroblasts [0.03%]
整合素β1：纤维母细胞合成结缔组织所需的机械信号传感器
Andrew Leask
Andrew Leask
Significance: There is no effective drug treatment for fibrosis (i.e., pathological scarring). Identifying the fundamental mechanisms responsible for normal and pathological connective tissue deposition is likely to yield...
A Paradigm of Fibroblast Activation and Dermal Wound Contraction to Guide the Development of Therapies for Chronic Wounds and Pathologic Scars [0.03%]
关于成纤维细胞活化和真皮创口收缩的范式以指导慢性伤口及病理性疤痕疗法的发展
Howard Levinson
Howard Levinson
Significance: Delayed wound healing and pathologic scarring are abnormal processes that can be thought of as occurring on a wound healing continuum, where insufficient wound contraction leads to nonhealing wounds, and ove...
Splinting Strategies to Overcome Confounding Wound Contraction in Experimental Animal Models [0.03%]
实验动物模型中克服伤口收缩的夹板策略
Jeffrey M Davidson,Fang Yu,Susan R Opalenik
Jeffrey M Davidson
Significance: Clinical healing by secondary intention frequently occurs in skin that is firmly anchored to underlying (human) connective tissue. Small animals (rodents) are extensively utilized to model human cutaneous wo...
Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention [0.03%]
肌成纤维细胞在伤口收缩、瘢痕和纤维化中的机械调节：新的治疗干预机会
Livingston Van De Water,Scott Varney,James J Tomasek
Livingston Van De Water
Significance: Myofibroblasts are responsible for wound closure that occurs in healed acute wounds. However, their actions can result in disfiguring scar contractures, compromised organ function, and a tumor promoting stro...
A Snapshot of Direct Cell-Cell Communications in Wound Healing and Scarring [0.03%]
伤口愈合和瘢痕形成过程中的细胞直接通讯研究进展
H Paul Ehrlich
H Paul Ehrlich
Significance: The repair of wounds usually terminates with a scar. The healing from a severe tissue loss can create a new clinical problem, excessive scarring. Approaches to prevent excessive scarring will optimize the re...