Comparison of Markers and Functional Attributes of Human Adipose-Derived Stem Cells and Dedifferentiated Adipocyte Cells from Subcutaneous Fat of an Obese Diabetic Donor [0.03%]
人肥胖糖尿病供体皮下脂肪来源的分化脂肪细胞和成脂诱导前的间充质干细胞的标志物及功能属性比较研究
James E Watson,Niketa A Patel,Gay Carter et al.
James E Watson et al.
Objective: Adipose tissue is a robust source of adipose-derived stem cells (ADSCs) that may be able to provide secreted factors that promote the ability of wounded tissue to heal. However, adipocytes also have the potential to dedifferentia...
William J Ennis,Audrey Sui,Amelia Bartholomew
William J Ennis
Significance: The number of patients with nonhealing wounds has rapidly accelerated over the past 10 years in both the United States and worldwide. Some causative factors at the macro level include an aging population, ep...
Disclosure of the Culprits: Macrophages-Versatile Regulators of Wound Healing [0.03%]
揭穿“真凶”：巨噬细胞——伤口愈合的多面调控者
Anca Sindrilaru,Karin Scharffetter-Kochanek
Anca Sindrilaru
Significance: Macrophages are invariably present and tightly regulate all phases of adult wound healing, including inflammation, granulation tissue formation, and matrix deposition with the unavoidable outcome of scar for...
Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments [0.03%]
湿润、潮湿和干燥环境对伤口愈合和炎症的临床影响
Johan P E Junker,Rami A Kamel,E J Caterson et al.
Johan P E Junker et al.
Significance: Successful treatment of wounds relies on precise control and continuous monitoring of the wound-healing process. Wet or moist treatment of wounds has been shown to promote re-epithelialization and result in ...
Chemokines and Their Receptors Are Key Players in the Orchestra That Regulates Wound Healing [0.03%]
趋化因子及其受体在调控伤口愈合过程中的关键作用
Manuela Martins-Green,Melissa Petreaca,Lei Wang
Manuela Martins-Green
Significance: Normal wound healing progresses through a series of overlapping phases, all of which are coordinated and regulated by a variety of molecules, including chemokines. Because these regulatory molecules play rol...
Systems-Level Lipid Analysis Methodologies for Qualitative and Quantitative Investigation of Lipid Signaling Events During Wound Healing [0.03%]
用于伤口愈合过程中脂质信号事件的定性和定量分析的系统水平脂质分析方法学
Dayanjan S Wijesinghe,Charles E Chalfant
Dayanjan S Wijesinghe
Objective: Accumulating evidence implicates a prominent role for lipid signaling molecules in the regulation of wound healing. These lipids regulate hemostasis, onset and resolution of inflammation, migration and prolifer...
Cordelia Ziraldo,Qi Mi,Gary An et al.
Cordelia Ziraldo et al.
Objective: Inflammation is both central to proper wound healing and a key driver of chronic tissue injury via a positive-feedback loop incited by incidental cell damage. We seek to derive actionable insights into the role...
Tomasz Arodz,Danail Bonchev,Robert F Diegelmann
Tomasz Arodz
Objective: The wound healing process is well-understood on the cellular and tissue level; however, its complex molecular mechanisms are not yet uncovered in their entirety. Viewing wounds as perturbed molecular networks p...
Evelien M Bunnik,Karine G Le Roch
Evelien M Bunnik
Objective: Over the past decade, the development of high-throughput technologies for DNA and protein analysis has revolutionized the ways in which cells can be studied. Within a relatively short time frame, research has c...
Ben Readhead,Joel Dudley
Ben Readhead
Significance: A majority of therapeutic interventions occur late in the pathological process, when treatment outcome can be less predictable and effective, highlighting the need for new precise and preventive therapeutic ...