Chemokines and Their Receptors Are Key Players in the Orchestra That Regulates Wound Healing [0.03%]
趋化因子及其受体在调控伤口愈合过程中的关键作用
Manuela Martins-Green,Melissa Petreaca,Lei Wang
Manuela Martins-Green
Significance: Normal wound healing progresses through a series of overlapping phases, all of which are coordinated and regulated by a variety of molecules, including chemokines. Because these regulatory molecules play rol...
Systems-Level Lipid Analysis Methodologies for Qualitative and Quantitative Investigation of Lipid Signaling Events During Wound Healing [0.03%]
用于伤口愈合过程中脂质信号事件的定性和定量分析的系统水平脂质分析方法学
Dayanjan S Wijesinghe,Charles E Chalfant
Dayanjan S Wijesinghe
Objective: Accumulating evidence implicates a prominent role for lipid signaling molecules in the regulation of wound healing. These lipids regulate hemostasis, onset and resolution of inflammation, migration and prolifer...
Cordelia Ziraldo,Qi Mi,Gary An et al.
Cordelia Ziraldo et al.
Objective: Inflammation is both central to proper wound healing and a key driver of chronic tissue injury via a positive-feedback loop incited by incidental cell damage. We seek to derive actionable insights into the role...
Tomasz Arodz,Danail Bonchev,Robert F Diegelmann
Tomasz Arodz
Objective: The wound healing process is well-understood on the cellular and tissue level; however, its complex molecular mechanisms are not yet uncovered in their entirety. Viewing wounds as perturbed molecular networks p...
Evelien M Bunnik,Karine G Le Roch
Evelien M Bunnik
Objective: Over the past decade, the development of high-throughput technologies for DNA and protein analysis has revolutionized the ways in which cells can be studied. Within a relatively short time frame, research has c...
Ben Readhead,Joel Dudley
Ben Readhead
Significance: A majority of therapeutic interventions occur late in the pathological process, when treatment outcome can be less predictable and effective, highlighting the need for new precise and preventive therapeutic ...
Michael Januszyk,Geoffrey C Gurtner
Michael Januszyk
Significance: Wound repair is a complex biological process that integrates multiple physiologic pathways to restore skin homeostasis after a wide array of gross and anatomical insults. As such, a scientific examination of...
Asheesh Gupta,Pinar Avci,Tianhong Dai et al.
Asheesh Gupta et al.
Significance: Wound care is an important area of medicine considering the increasing age of the population who may have diverse comorbidities. Light-based technology comprises a varied set of modalities of increasing rele...
Dynamic Regulation of Integrin α6β4 During Angiogenesis: Potential Implications for Pathogenic Wound Healing [0.03%]
角蛋白5/14阳性细胞在血管生成过程中的动态调节及其对病理性伤口修复的潜在影响
Diana Desai,Purva Singh,Livingston Van De Water et al.
Diana Desai et al.
Objective: Angiogenesis is an essential component of normal cutaneous wound repair, but is altered in pathogenic forms of wound healing, such as chronic wounds and fibrosis. We previously reported that endothelial express...
Ge Zhao,Marcia L Usui,Soyeon I Lippman et al.
Ge Zhao et al.
Significance: The incidence, cost, morbidity, and mortality associated with non-healing of chronic skin wounds are dramatic. With the increasing numbers of people with obesity, chronic medical conditions, and an increasin...