Comparative Analysis of Animal Models in Wound Healing Research and the Utility for Humanized Mice Models [0.03%]
伤口愈合研究中动物模型的比较分析及人源化小鼠模型的应用价值
Haley Cirka,Tammy T Nguyen
Haley Cirka
Significance: The rise of chronic nonhealing lower extremity wounds among aging, diabetic, obese, and cardiovascular patients has surged. Despite a decade of drug testing in preclinical animal models, few federally approved therapies have e...
SEMTWIST Quantification of Biofilm Infection in Human Chronic Wound Using Scanning Electron Microscopy and Machine Learning [0.03%]
基于扫描电子显微镜和机器学习的人类慢性伤口生物膜感染量化(SEMTWIST)
Surabhi Singh,Fabio Muniz De Oliveira,Cong Wang et al.
Surabhi Singh et al.
Objective: To develop scanning electron microscopy-based Trainable Weka (Waikato Environment for Knowledge Analysis) Intelligent Segmentation Technology (SEMTWIST), an open-source software tool, for structural detection and rigorous quantif...
Jessica Mroueh,Luisa Weber,Yori Endo et al.
Jessica Mroueh et al.
Significance: Volumetric muscle loss is defined as composite loss of muscle mass. Severe injuries result in permanent functional impairment. Treatment options are limited. Tissue engineering techniques utilizing scaffolds offer promise as a...
Anish Vasan,Suntae Kim,Emily Davis et al.
Anish Vasan et al.
Significance: Nonhealing or chronic wounds represent a significant and growing global health concern, imposing substantial burdens on individuals, health care systems, and economies worldwide. Although the standard-of-care treatment involve...
Global Burden of Pressure Ulcer and Contributing Factors from 1990 to 2021: A Systematic Analysis with Forecasts to 2035 [0.03%]
1990年至2021年全球压力性溃疡疾病负担及影响因素：1990至2021年的系统分析和2035年前的预测
Hanyu Lei,Kaihuan Zhong,Zhizhao Chen et al.
Hanyu Lei et al.
Objective: To analyze global trends in pressure ulcer (PU) burden, focusing on microbial infections, antimicrobial resistance (AMR), and climate change from 1990 to 2021, and to forecast location-specific disease burdens through 2035. Appro...
Systematic Review of Relevant Biomarkers for Human Connective Tissue Repair and Healing Outcome: Implications for Understanding Healing Processes and Design of Healing Interventions [0.03%]
人类连接组织修复和愈合结局相关生物标志物的系统评价：理解愈合过程及设计干预措施的意义
Junyu Chen,Xiaoxue Fu,Aisha S Ahmed et al.
Junyu Chen et al.
Objective: The healing process following connective tissue (CT) injuries is complex, resulting in variable and often suboptimal outcomes. Patients undergoing CT repair frequently experience healing failures, compromised function, and chroni...
Chondrocyte Mitochondrial Quality Control: A Novel Insight into Osteoarthritis and Cartilage Regeneration [0.03%]
软骨细胞线粒体质量控制：关节炎及软骨再生新视角
Jinni Wu,Jiawen Xu,Menghan Zhang et al.
Jinni Wu et al.
Significance: Osteoarthritis (OA), one of the most prevalent joint diseases affecting more than 240 million people, strongly influences human health and reduces life quality. This review aims to fill the current research gap regarding the a...
Integration of Flow Cytometry and Single-Cell RNA Sequencing Analysis to Explore the Fibroblast Subpopulations in Keloid that Correlate with Recurrence [0.03%]
整合流式细胞术和单细胞RNA测序分析探索与瘢痕增生复发相关的胶原蛋白合成长强的瘢痕成纤维亚群
Ruxin Xie,Chenyu Li,Tian Zhao et al.
Ruxin Xie et al.
Objective: Fibroblasts (FBs) are the cytological basis of keloid (KD) formation. This study aimed to identify the key pathogenic target cell subpopulation involved in KD recurrence. Approach: Single-cell RNA sequencing data were retrieved f...
Advancing Therapeutic Solutions for Burn Wounds: Potential Use of Noninvasive Ultrasound-Driven Splenic Stimulation [0.03%]
烧伤伤口治疗方案的新进展：非侵入性超声驱动脾刺激的潜在应用
Ahmed Sami Raihane,David G Armstrong,T Justin Gillenwater et al.
Ahmed Sami Raihane et al.
Significance: Burn wound injuries are a global health challenge, affecting millions annually and resulting in significant morbidity, mortality, and economic burden. The urgent need for accessible and cost-effective therapeutic alternatives,...
Evidence Mapping of Clinical Practice Guideline Recommendations for Self-Management Strategies of Diabetic Foot Ulcers [0.03%]
糖尿病足溃疡自我管理策略的临床实践指南推荐循证映射分析
Shupeng Shi,Piaoyu Yang,Xingzhou Liu et al.
Shupeng Shi et al.
Significance: Diabetic foot ulcer (DFU) is a common complication of diabetes, characterized by chronic, hard-to-heal wounds that can lead to serious infections and amputations. Effective self-management is crucial for treatment and preventi...