AURKA Activates FOXO3a to Form a Positive Feedback Loop in the Proliferation and Migration of Keloid Fibroblasts [0.03%]
AURKA活化FOXO3a形成促进瘢痕纤维细胞增殖和迁移的正反馈环路
Xi Chu,Jiaqi Sun,Siya Dai et al.
Xi Chu et al.
Objective: Keloids are benign fibroproliferative disorders with invasive growth exceeding the wound boundary. Aurora kinase A (AURKA) is a serine/threonine kinase highly expressed in various tumors, facilitating tumor growth and invasion. C...
Lower Extremity Traumatic Wound Management: Relative Significance of Negative Pressure Wound Therapy in the Orthopedic Setting [0.03%]
负压伤口治疗在骨科创伤下肢创面处理中的应用及意义
Evania Lok,Timothy Oe,Sally Ng
Evania Lok
Significance: Lower extremity traumatic wounds are associated with numerous perioperative challenges. Their etiologies determine the characteristics and extent of the injury. The timing of subsequent surgical intervention and wound healing ...
Extrusion-Based 3D Bioprinting of Bioactive and Piezoelectric Scaffolds as Potential Therapy for Treating Critical Soft Tissue Wounds [0.03%]
用于治疗关键软组织伤口的生物活性和压电支架的挤出式3D生物打印
Surendrasingh Y Sonaye,Smriti Bohara,Breanne L Welsh et al.
Surendrasingh Y Sonaye et al.
Objective: This study focuses on developing bioactive piezoelectric scaffolds that could deliver bioelectrical cues to potentially treat injuries to soft tissues such as skeletal muscles and promote active regeneration. Approach: To address...
Current and Future Directions in Fluorescence Imaging Guided Debridement [0.03%]
当前和未来的荧光成像引导清创术的发展方向
Rachael Orkin,Arjun Sharma,David G Armstrong et al.
Rachael Orkin et al.
Sterility and reduction of the bioburden are crucial for healing in chronic wounds such as diabetic foot ulcers (DFU). Although there are methods for measuring bioburdens, such as semi-quantitative analysis of swab/biopsy samples, microbiol...
Pablo Ottolino
Pablo Ottolino
Significance: The laparotomy is a common surgical procedure with a wide range of indications. Ideally, once the goals of surgery were achieved, the incision edges could then be approximated and the abdomen primarily closed. However, in some...
Chandan K Sen
Chandan K Sen
Standardized care is crucial in healthcare for ensuring consistent, safe, high-quality, efficient, and evidence-based practices. Care pathways that standardize procedures promote adherence to best practices, reduce variability in treatment,...
Prospective Evaluation of Vitamin C, Vitamin D, and Zinc Deficiencies in Patients with Active Foot Ulceration [0.03%]
前瞻性评估维生素C、维生素D和锌缺乏在活动性足溃疡患者中的作用
Nada Bechara,Peta Tehan,Jenny E Gunton
Nada Bechara
Objective: This prospective cohort study aimed to determine the relationship between serum vitamin C, D, and zinc on foot wound healing and compare time to healing in individuals who are deficient versus those who have adequate levels. Appr...
Standardized Reporting of Research on Exosomes to Ensure Rigor and Reproducibility [0.03%]
关于外泌体研究的标准化报告以确保其严谨性和可重复性
Anita Yadav,Yi Xuan,Chandan K Sen et al.
Anita Yadav et al.
Significance: The study of extracellular vesicles (EV), especially exosomes, has unlocked new avenues in understanding cellular communication and potential therapeutic avenues. ...
Can Electrical Stimulation Prevent Recurrence of Keloid Scars: A Scoping Review [0.03%]
电刺激能否预防瘢痕增生复发：系统综述
Robert Edward George,Caroline C Bay,Sarah M Thornton et al.
Robert Edward George et al.
Objective: Keloids represent a symptomatic, aberrant healing process that is difficult to treat with high recurrence rates spanning from 55-100% if treated via excision without adjuvant therapy. Electrical stimulation (ES...
Muscle fibrosis, NF-κB, and TGF-β are differentially altered in two models of paralysis (Botox vs. Neurectomy) [0.03%]
肉毒杆菌素和神经切断诱导的麻痹模型中肌肉纤维化、NF-κB 和 TGF-β 的变化不同
James T Redden,Jingyao Deng,David J Cohen et al.
James T Redden et al.
Objective: Volumetric muscle loss (VML) results in intramuscular axotomy, denervating muscle and leading to paralysis and loss of muscle function. Once the nerve is damaged, paralyzed skeletal muscle will atrophy and accu...