A First-in-Human Randomized Clinical Study Investigating the Safety and Tolerability of Stabilized Hypochlorous Acid in Patients with Chronic Leg Ulcers [0.03%]
关于次氯酸在慢性腿部溃疡患者中安全性和耐受性的首次人体随机临床研究
Magnus Mustafa Fazli,Klaus Kirketerp-Møller,David Peick Sonne et al.
Magnus Mustafa Fazli et al.
Objective: Biofilm infections in chronic wounds are common and pose a significant clinical challenge. This challenge was addressed by developing the SoftOx Biofilm Eradicator (SBE) composed of hypochlorous acid (HOCl) and acetic acid with s...
Systematic Review of Cellular, Acellular, and Matrix-like Products and Indirect Treatment Comparison Between Cellular/Acellular and Amniotic/Nonamniotic Grafts in the Management of Diabetic Foot Ulcers [0.03%]
有关细胞型、非细胞型和类似基质型产品治疗糖尿病足溃疡的间接比较及系统评价
Jaideep Banerjee,Andrew Lasiter,Leo Nherera
Jaideep Banerjee
Significance: This Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant review focuses on the efficacy of cellular, acellular, and matrix-like products (CAMPs) in the management of diabetic foot ulcers (DFUs...
The WOUND-Q Function and Symptoms Scales for Chronic Lower Extremity Wounds: A Validation Study [0.03%]
慢性下肢难愈合创面WOUND-Q功能和症状量表的验证性研究
Nina Vestergaard Simonsen,Anne F Klassen,Charlene Rae et al.
Nina Vestergaard Simonsen et al.
Objective: Determine the validity and reliability of the LIMB-Q scales, Function, and Symptoms in patients with chronic lower extremity wounds. Approach: Cognitive debriefing interviews with people with current or previous wounds were condu...
Biomaterial-Based Regenerative Strategies for Volumetric Muscle Loss: Challenges and Solutions [0.03%]
基于生物材料的体积性肌肉损失再生策略：挑战与解决方案
Charlene W Cai,Josh A Grey,Dirk Hubmacher et al.
Charlene W Cai et al.
Significance: Volumetric muscle loss (VML) is caused by the loss of significant amounts of skeletal muscle tissue. VML cannot be repaired by intrinsic regenerative processes, resulting in permanent loss of muscle function and disability. Cu...
Testosterone Promotes Nerve Tethering and Acellular Biomaterial Perineural Fibrosis in a Rat Wound Repair Model [0.03%]
睾酮通过促进神经缠绕和无细胞生物材料的硬脑膜纤维化从而加重坐骨神经束膜损伤后的继发性损伤(以大鼠为模型)
Calvin R Schuster,Erik Reiche,Patrick R Keller et al.
Calvin R Schuster et al.
Objective: Nerve scarring after traumatic or iatrogenic exposure can lead to impaired function and pain. Nerve-adjacent biomaterials promoting a regenerative tissue response may help reduce perineural fibrosis. Our prior work suggests that ...
Use of Acellular Matrices as Scaffolds in Cartilage Regeneration: A Systematic Review [0.03%]
透明质酸钠注射液用于骨关节炎的镇痛作用：一项随机、双盲、对照研究
Wolfram Demmer,Jannik Schinacher,Paul Severin Wiggenhauser et al.
Wolfram Demmer et al.
Significance: Cartilage regeneration remains a significant challenge in the field of regenerative medicine. Acellular matrix (AM)-based cartilage tissue regeneration offers an innovative approach to repairing cartilage defects by providing ...
Identifying the Pattern Characteristics of Anoikis-Related Genes in Keloid [0.03%]
与外伤相关的瘢痕中anoikis相关基因的模式特征识别
Ruxin Xie,Chenyu Li,Jiao Yun et al.
Ruxin Xie et al.
Objective: Anoikis is a kind of programmed cell death that is triggered when cells lose contact with each other or with the matrix. However, the potential value of anoikis-related genes (ARGs) in keloid (KD) has not been investigated. Appro...
Exploring the Efficacy of Selected Allografts in Chronic Wound Healing: Evidence from Murine Models and Clinical Data for a Proposed Treatment Algorithm [0.03%]
探究选定同种异体移植物在慢性伤口愈合中的疗效：来自小鼠模型和临床数据的证据以及提出的治疗算法
Charlotte R Reed,Tokoya Williams,Iulianna Taritsa et al.
Charlotte R Reed et al.
Significance: Chronic wounds can lead to poor outcomes for patients, with risks, including amputation and death. In the United States, chronic wounds affect 2.5% of the population and cost up to $28 billion per year in primary health care c...
Shannon M Clayton,Sasha H Shafikhani,Athena M Soulika
Shannon M Clayton
Significance: The incidence of diabetes continues to rise throughout the world in an alarming rate. Diabetic patients often develop diabetic foot ulcers (DFUs), many of which do not heal. Non-healing DFUs are a major cause of hospitalizatio...
Assessment of Patient-Reported Outcomes for Closed-Incision Negative Pressure Therapy with Wide-Coverage Dressings in Simple Mastectomy and Immediate Implant-Based Breast Reconstruction [0.03%]
带广泛覆盖敷料的封闭切口负压伤口治疗在乳腺癌保乳术和即刻假体乳房重建术后应用的患者报告结局评估研究
Benjamin G Baker,Andrew Pieri
Benjamin G Baker
Objective: A new configuration of closed-incision negative pressure therapy (ciNPT) dressings now covers the incision and a broader area of peri-incisional tissues. We have implemented these ciNPT dressings following simple mastectomy (SM) ...