Sabine M Hölter,Jan Einicke,Bettina Sperling et al.
Sabine M Hölter et al.
Phenotyping of inbred mouse strains and genetically modified mouse models for characteristics related to neuropsychiatric diseases includes assessing their anxiety-related behavior. A variety of tests have been developed to measure anxiety ...
Jorming Goh,Warren Ladiges
Jorming Goh
Voluntary wheel running in the mouse is used to assess physical performance and endurance and to model exercise training as a way to enhance health. Wheel running is a voluntary activity in contrast to other experimental exercise models in ...
Kristin Eckel-Mahan,Paolo Sassone-Corsi
Kristin Eckel-Mahan
Circadian rhythms take place with a periodicity of 24 hr, temporally following the rotation of the earth around its axis. Examples of circadian rhythms are the sleep/wake cycle, feeding, and hormone secretion. Light powerfully entrains the ...
Diabetic Retinopathy: Retina-Specific Methods for Maintenance of Diabetic Rodents and Evaluation of Vascular Histopathology and Molecular Abnormalities [0.03%]
糖尿病视网膜病变：糖尿病啮齿动物的视网膜特异性维持方法及血管病理组织学和分子异常评估方法
Alexander Veenstra,Haitao Liu,Chieh Allen Lee et al.
Alexander Veenstra et al.
Diabetic retinopathy is a major cause of visual impairment, which continues to increase in prevalence as more and more people develop diabetes. Despite the importance of vision, the retina is one of the smallest tissues in the body, and spe...
An Overview of Typical Infections of Research Mice: Health Monitoring and Prevention of Infection [0.03%]
常用实验小鼠感染性疾病概论：健康监测与预防措施
James R Fahey,Haiyan Olekszak
James R Fahey
There are many reasons to keep research mice healthy and free from infections. The two most important of these are to protect the health and welfare of research mice and to prevent infections from negatively impacting research. Just as the ...
Mouse Necropsy [0.03%]
小鼠剖检
Piper M Treuting,Jessica M Snyder
Piper M Treuting
Necropsy (also known as autopsy) is the post-mortem dissection of bodies after euthanasia or death and is a scientific examination conducted to observe and dissect the organs, collect tissues, and determine the extent of grossly evident dis...
Exploration of Energy Metabolism in the Mouse Using Indirect Calorimetry: Measurement of Daily Energy Expenditure (DEE) and Basal Metabolic Rate (BMR) [0.03%]
小鼠能量代谢的间接 calorimeter 测定：每日能量消耗(DEE)和基础代谢率(BMR)的测定
Carola W Meyer,Peter Reitmeir,Matthias H Tschöp
Carola W Meyer
Current comprehensive mouse metabolic phenotyping involves studying energy balance in cohorts of mice via indirect calorimetry, which determines heat release from changes in respiratory air composition. Here, we describe the measurement of ...
Charles J Donnelly,Carol J Bult
Charles J Donnelly
In this unit we discuss the importance of implementing a data management system for research animal colonies. We focus on drivers such as ethical considerations, cost, and data integrity. We also discuss keys to effective data management an...
One-Step Vital Staining of Presynaptic Terminals and Post-Synaptic Receptors at Neuromuscular Junctions in Mouse Skeletal Muscle [0.03%]
一种一步法活体染色神经肌肉突触前终末和突触后受体的新技术
Richard R Ribchester
Richard R Ribchester
This protocol describes vital staining of neuromuscular junctions in the mouse triangularis sterni muscle in one incubation step, combining presynaptic, motor nerve terminal staining with the styryl dye FM1-43, which labels recycling synapt...
Matthias Rosenwald,Aliki Perdikari,Elisabeth Weber et al.
Matthias Rosenwald et al.
The Western world is in the midst of an epidemic of obesity, which is the cause of severe clinical complications such as type 2 diabetes, hypertension, and cardiovascular disease. Obesity develops when energy intake chronically exceeds ener...