Mouse Models of Asthma [0.03%]
哮喘的小鼠模型
Nincy Debeuf,Eline Haspeslagh,Mary van Helden et al.
Nincy Debeuf et al.
Allergic asthma is a chronic inflammatory disease of the conducting airways characterized by the presence of allergen-specific IgE, Th2 cytokine production, eosinophilic airway inflammation, bronchial hyperreactivity, mucus overproduction, ...
Jonathan M Williams,Carrie A Duckworth,Kate Vowell et al.
Jonathan M Williams et al.
The murine intestinal tract represents a difficult organ system to study due to its long convoluted tubular structure, narrow diameter, and delicate mucosa which undergoes rapid changes after sampling prior to fixation. These features do no...
Céline Caravagna,Alexandre Jaouën,Franck Debarbieux et al.
Céline Caravagna et al.
Neuroinflammation demands a comprehensive appraisal in situ to gain in-depth knowledge on the roles of particular cells and molecules and their potential roles in therapy. Because of the lack of appropriate tools, direct visualization of ce...
Laura Mangiavini,Christophe Merceron,Ernestina Schipani
Laura Mangiavini
To investigate skeletal development, pathophysiological mechanisms of cartilage and bone disease, and eventually assess innovative treatments, the mouse is a very important resource. During embryonic development, mesenchymal condensations a...
Wenning Qin,Peter M Kutny,Richard S Maser et al.
Wenning Qin et al.
The CRISPR-Cas9 system in bacteria and archaea has recently been exploited for genome editing in various model organisms, including mice. The CRISPR-Cas9 reagents can be delivered directly into the mouse zygote to derive a mutant animal car...
Colin K L Phoon,Daniel H Turnbull
Colin K L Phoon
The mouse is the mammalian model of choice for investigating cardiovascular biology, given our ability to manipulate it by genetic, pharmacologic, mechanical, and environmental means. Imaging is an important approach to phenotyping both fun...
Analysis of Mitochondrial Respiratory Chain Supercomplexes Using Blue Native Polyacrylamide Gel Electrophoresis (BN-PAGE) [0.03%]
利用蓝色原质聚丙烯酰胺凝胶电泳（BN-PAGE）分析线粒体呼吸链超级复合物
Pooja Jha,Xu Wang,Johan Auwerx
Pooja Jha
Mitochondria are cellular organelles that harvest energy in the form of ATP through a process termed oxidative phosphorylation (OXPHOS), which occurs via the protein complexes of the electron transport chain (ETC). In recent years it has be...
Optimized Heart Sampling and Systematic Evaluation of Cardiac Therapies in Mouse Models of Ischemic Injury: Assessment of Cardiac Remodeling and Semi-Automated Quantification of Myocardial Infarct Size [0.03%]
优化的心脏取样及小鼠缺血损伤模型心脏治疗系统评价：心室重构评估及心肌梗死面积半自动量化分析方法
Mariana Valente,Ana Araújo,Tiago Esteves et al.
Mariana Valente et al.
Cardiac therapies are commonly tested preclinically in small-animal models of myocardial infarction. Following functional evaluation, post-mortem histological analysis is essential to assess morphological and molecular alterations underlyin...
Assessing Cognition in Mice [0.03%]
评估小鼠的认知能力
Sabine M Hölter,Lillian Garrett,Jan Einicke et al.
Sabine M Hölter et al.
Genetically modified mouse models have proven useful to study learning and memory processes and the neurocircuitry and molecular mechanisms involved, as well as to develop therapies for diseases involving cognitive impairment. A variety of ...
A Mouse Primary Hepatocyte Culture Model for Studies of Circadian Oscillation [0.03%]
小鼠原代肝细胞培养模型用于昼夜节律震荡研究
Penny C Molyneux,Lorna A Pyle,Martha Dillon et al.
Penny C Molyneux et al.
Circadian rhythms regulate many aspects of behavior and physiological processes, and, through external signals, help an organism entrain to its environment. These rhythms are driven by circadian clocks in many cells and tissues within our b...