Histopathological Evaluation of Skeletal Muscle with Specific Reference to Mouse Models of Muscular Dystrophy [0.03%]
以小鼠肌营养不良模型为重点的骨骼肌组织病理学评价研究
Rebecca L Terry,Dominic J Wells
Rebecca L Terry
The muscular dystrophies are a diverse group of degenerative diseases for which many mouse models are available. These models are frequently used to assess potential therapeutic interventions and histological evaluation of multiple muscles ...
Measurement of Intestinal and Peripheral Cholesterol Fluxes by a Dual-Tracer Balance Method [0.03%]
双标平衡法测定肠和外周胆固醇转运率
Onne A H O Ronda,Theo H van Dijk,H J Verkade et al.
Onne A H O Ronda et al.
Long-term elevated plasma cholesterol levels put individuals at risk for developing atherosclerosis. Plasma cholesterol levels are determined by the balance between cholesterol input and output fluxes. Here we describe in detail the methodo...
Metabolic Profiling and Quantification of Neurotransmitters in Mouse Brain by Gas Chromatography-Mass Spectrometry [0.03%]
气相色谱-质谱法测定小鼠脑代谢轮廓及神经递质的含量
Christian Jäger,Karsten Hiller,Manuel Buttini
Christian Jäger
Metabolites are key mediators of cellular functions, and have emerged as important modulators in a variety of diseases. Recent developments in translational biomedicine have highlighted the importance of not looking at just one disease mark...
Anna Mikhaleva,Meghna Kannan,Christel Wagner et al.
Anna Mikhaleva et al.
This article describes a series of standard operating procedures for morphological phenotyping of the mouse brain using basic histology. Many histological studies of the mouse brain use qualitative approaches based on what the human eye can...
Light and Electron Microscopy Methods for Examination of Cochlear Morphology in Mouse Models of Deafness [0.03%]
小鼠耳聋模型下耳蜗形态检查的光镜和电镜方法学研究
Andrew Parker,Lauren Chessum,Philomena Mburu et al.
Andrew Parker et al.
Mice are an invaluable model organism for the study of auditory function. Even though there are differences in size and frequency response, the anatomy and physiology of the mouse and human ear are remarkably similar. In addition, the tools...
Alison Hugill,Kenju Shimomura,Roger D Cox
Alison Hugill
This article describes detailed protocols for in vitro measurements of insulin function and secretion in isolated mouse islets for the analysis of glucose homeostasis. We specify a method of enzyme digestion and hand picking to isolate and ...
Corinne G Jolivalt,Katie E Frizzi,Lucie Guernsey et al.
Corinne G Jolivalt et al.
Peripheral neuropathy is a frequent complication of chronic diabetes that most commonly presents as a distal degenerative polyneuropathy with sensory loss. Around 20% to 30% of such patients may also experience neuropathic pain. The underly...
Lee Moir,Liz Bentley,Roger D Cox
Lee Moir
In mice with altered body composition, establishing whether it is food intake or energy expenditure, or both, that is the major determinant resulting in changed energy balance is important. In order to ascertain where the imbalance is, the ...
Development of a Representative Mouse Model with Nonalcoholic Steatohepatitis [0.03%]
非酒精性脂肪肝病代表性小鼠模型的建立
Jef Verbeek,Ans Jacobs,Pieter Spincemaille et al.
Jef Verbeek et al.
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in the Western world. It represents a disease spectrum ranging from isolated steatosis to non-alcoholic steatohepatitis (NASH). In particular, NASH can evolve to ...
An Overview of Mouse Models of Nonalcoholic Steatohepatitis: From Past to Present [0.03%]
非酒精性脂肪肝病小鼠模型的研究进展：过去与现在
Ans Jacobs,Anne-Sophie Warda,Jef Verbeek et al.
Ans Jacobs et al.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world. It is associated with obesity and type 2 diabetes and represents a spectrum of histological abnormalities ranging from simple steatosis...