Assessing Healthspan and Lifespan Measures in Aging Mice: Optimization of Testing Protocols, Replicability, and Rater Reliability [0.03%]
评估衰老小鼠健康寿命和寿命指标：测试方案的优化、可重复性和评价者可靠性
Stacey J Sukoff Rizzo,Laura C Anderson,Torrian L Green et al.
Stacey J Sukoff Rizzo et al.
The relationship between chronological age (lifespan) and biological age (healthspan) varies amongst individuals. Understanding the normal trajectory and characteristic traits of aging mice throughout their lifespan is important for selecti...
Evaluation of the Estrous Cycle, Reproductive Tract, and Mammary Gland in Female Mice [0.03%]
雌性小鼠发情周期、生殖道和乳腺的评估
Justin D Vidal,Adam J Filgo
Justin D Vidal
Evaluation of the female reproductive system is an important part of basic reproductive biology research, toxicology testing, and mutant mouse phenotype assessment. The female reproductive system is dynamic and the onset of puberty and the ...
Jessica B Graham,Jessica L Swarts,Jennifer M Lund
Jessica B Graham
The use of a mouse model to study the breadth of symptoms and disease severity seen in human West Nile virus (WNV) infection can provide insight into the kinetics of the immune response and the specific pathways responsible for control of W...
The Study of Host Immune Responses Elicited by the Model Murine Hookworms Nippostrongylus brasiliensis and Heligmosomoides polygyrus [0.03%]
由啮齿动物寄生钩虫模型Nippostrongylusbrasiliensisa和Heligmosomoidespolygyrust诱导的宿主免疫反应研究
T Bouchery,B Volpe,K Shah et al.
T Bouchery et al.
Hookworm infections (Necator americanus or Ancylostoma duodenale) represent a major neglected tropical disease, affecting approximately 700 million people worldwide, and can cause severe morbidity due to the need for these worms to feed on ...
Annemarie Zimprich,Jörn Niessing,Lior Cohen et al.
Annemarie Zimprich et al.
Adaptive social behavior is important in mammals, both for the well-being of the individual and for the thriving of the species. Dysfunctions in social behavior occur in many neurodevelopmental and psychiatric diseases, and research into th...
Pathology Evaluation of Developmental Phenotypes in Neonatal and Juvenile Mice [0.03%]
新生和幼年小鼠发育表型的病理学评估
Brad Bolon,Susan Newbigging,Kelli L Boyd
Brad Bolon
Necropsy (or autopsy) is the post mortem dissection of an animal to examine and collect organs and tissues in order to understand the effects and causes of disease. The systematic harvesting of samples at necropsy is an essential step in de...
Using Vascular Landmarks to Orient 3D Optical Coherence Tomography Images of the Mouse Eye [0.03%]
基于血管标志物的三维光学相干层析成像小鼠眼睛图像定位法
Mark P Krebs
Mark P Krebs
Comparing 3D structural information obtained by optical coherence tomography (OCT) requires accurate alignment of images acquired from individual subjects. Despite the widespread use of OCT to image the anterior and posterior mouse eye, few...
Wanze Chen,Vincent Gardeux,Antonio Meireles-Filho et al.
Wanze Chen et al.
Complex biological systems are composed of multiple cell types whose transcriptional activity can vary due to differences in cell state, environmental stimulation, or intrinsic programs. Conventional bulk analysis methods capture the averag...
Yibo Wu,Evan G Williams,Ruedi Aebersold
Yibo Wu
The quantitative measurement of the proteome has been shown to yield new insights into physiology and cell biology that cannot be determined from the genome and transcriptome because the quantitative relationship between transcriptome and p...
Microbiota Analysis Using an Illumina MiSeq Platform to Sequence 16S rRNA Genes [0.03%]
基于Illumina MiSeq平台的16S rDNA测序分析微生物菌群组成
Alexis Rapin,Céline Pattaroni,Benjamin J Marsland et al.
Alexis Rapin et al.
The microbiota have been shown to play an important role in diverse biological processes including immunity, metabolism, and digestion. Assessing the exact composition of the microbiota has proven challenging due to the often unknown growth...