Ultrasound-Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma [0.03%]
超声引导方法提高肝细胞癌异种移植瘤模型同源性的研究
Ghina Bou About,Emilie Thiebault,Marie Wattenhofer-Donzé et al.
Ghina Bou About et al.
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide. While curative approaches for early stage HCC exist, effective treatment options for advanced HCC are lacking. Furthermore, there are no efficient chemopr...
Marisa A Brake,Lacramioara Ivanciu,Susan A Maroney et al.
Marisa A Brake et al.
The mammalian blood coagulation system was designed to restrict blood loss due to injury as well as keep the blood fluid within the blood vessels of the organism. Blood coagulation activity in inbred mouse strains varies widely among strain...
Use of Isotope Tracers to Assess Lipid Absorption in Conscious Lymph Fistula Mice [0.03%]
同位素示踪法评估清醒淋巴外瘘小鼠脂质吸收率
Chih-Wei Ko,Jie Qu,Min Liu et al.
Chih-Wei Ko et al.
This protocol provides a comprehensive reference for the evolution of the lymph fistula model, the mechanism of lipid absorption, the detailed procedure for studying lipid absorption using the lymph fistula model, the interpretation of the ...
Máximo E Lange,Richard R E Uwiera,G Douglas Inglis
Máximo E Lange
Gnotobiotic mice are an established, robust model utilized in current research to study host-microbiota interactions. For years isolators have been used to rear germ-free and gnotobiotic mice. However, isolators can be costly and the segreg...
Yong Hong Chen,Megan S Keiser,Beverly L Davidson
Yong Hong Chen
Adeno-associated virus (AAV) vectors are exemplary tools for studying gene function in vivo and are particularly favorable for transferring genes of interest into brain tissues. They have shown great promise as a gene therapy vector for pre...
Yong Hong Chen,Megan S Keiser,Beverly L Davidson
Yong Hong Chen
Viral vectors are a promising tool for effective delivery of genetic material into cells. They take advantage of the natural ability of a virus to deliver a genetic payload into cells while being genetically modified such that their ability...
Techniques for Intracranial Stereotaxic Injections of Adeno-Associated Viral Vectors in Adult Mice [0.03%]
成年小鼠脑内立体定位腺相关病毒注射技术
Megan S Keiser,Yong Hong Chen,Beverly L Davidson
Megan S Keiser
Stereotaxic intracranial injection of viral vectors is a valuable technique to directly deliver genetic material to a specific population of cells in the central nervous system of a mouse model. This enables scientists to test candidate gen...
Andrew Blease,Patricia Das Neves Borges,Marcia Curtinha et al.
Andrew Blease et al.
With the increasing availability and complexity of mouse models of disease, either spontaneous or induced, there is a concomitant increase in their use in the analysis of pathogenesis. Among such diseases is osteoarthritis, a debilitating d...
Critical Assessment of the mdx Mouse with Ex Vivo Eccentric Contraction of the Diaphragm Muscle [0.03%]
体内离体膈肌向心和离心收缩对mdx小鼠的影响的批判性评估
Gregory C Addicks,Phillip Marshall,Bernard J Jasmin et al.
Gregory C Addicks et al.
Muscle function and health progressively deteriorate during the progression of muscle dystrophies. The ability to objectively characterize muscle function and muscle damage is useful not only when comparing variants of dystrophy models, but...
Shuaiyu Wang,Bao Zhang,Gregory C Addicks et al.
Shuaiyu Wang et al.
Muscle stem cells (MuSCs) are essential for maintaining muscle homeostasis by providing progenitor cells for muscle regeneration after injury and in muscular diseases. MuSC properties dynamically change, reflecting physiology or pathologica...