Inducing and characterizing liver regeneration in mice: Reliable models, essential "readouts" and critical perspectives [0.03%]
诱导和表征小鼠肝再生：可靠模型、必要评价指标与关键视角
Dimitrios C Mastellos,Robert A Deangelis,John D Lambris
Dimitrios C Mastellos
Elucidating the molecular circuitry that regulates regenerative responses in mammals has recently attracted considerable attention because of its emerging impact on modern bioengineering, tissue replacement technologies, and organ transplan...
Janet L Demayo,Jie Wang,Dongcai Liang et al.
Janet L Demayo et al.
The generation of transgenic mice by DNA microinjection is a powerful tool to investigate the molecular regulation of gene expression, development, and disease. The power of this technology is that foreign DNA can be introduced into every c...
Methods for studying rodent intestinal lipoprotein production and metabolism [0.03%]
研究啮齿动物肠源性脂蛋白生成和代谢的方法
Alison B Kohan,Philip N Howles,Patrick Tso
Alison B Kohan
Lipid absorption begins with the digestion of dietary triacylglycerol and ultimately results in the secretion of triacylglycerol in chylomicrons into the lymphatics. Additionally, the intestine also secretes numerous proteins and peptides i...
Tanya Burkholder,Charmaine Foltz,Eleanor Karlsson et al.
Tanya Burkholder et al.
Good science and good animal care go hand in hand. A sick or distressed animal does not produce the reliable results that a healthy and unstressed animal produces. This unit describes the essentials of assessing mouse health, colony health ...
Developing genetically engineered mouse models to study tumor suppression [0.03%]
开发基因工程小鼠模型研究肿瘤抑制功能
Shunbin Xiong,Jan Parker-Thornburg,Guillermina Lozano
Shunbin Xiong
Since the late 1980s, the tools to generate mice with deletions of tumor suppressors have made it possible to study such deletions in the context of a whole animal. Deletion of some tumor suppressors results in viable mice while deletion of...
David Ho,Xin Zhao,Shumin Gao et al.
David Ho et al.
The majority of current cardiovascular research involves studies in genetically engineered mouse models. The measurement of heart rate is central to understanding cardiovascular control under normal conditions, with altered autonomic tone, ...
Echocardiography in Mice [0.03%]
小鼠超声心动图
Shumin Gao,David Ho,Dorothy E Vatner et al.
Shumin Gao et al.
Murine models have been utilized with increasing frequency mainly due to availability of genetically engineered models. With advancement in high spatial and temporal resolution, echocardiography is used extensively for the evaluation of car...
Xin Zhao,David Ho,Shumin Gao et al.
Xin Zhao et al.
The use of mice for the evaluation and study of cardiovascular pathophysiology is growing rapidly, primarily due to the relative ease for developing genetically engineered mouse models. Arterial pressure monitoring is central to the evaluat...