Chromosomal instability in in vitro cultured mouse hematopoietic cells associated with oxidative stress [0.03%]
氧化应激导致的小鼠造血细胞体外培养中的染色体不稳定现象
Alice M Liu,William W Qu,Xia Liu et al.
Alice M Liu et al.
Hematopoietic stem cells (HSCs) that give rise to all blood cell types are important vehicles for cell-based and gene therapies. After isolation from the bone marrow, HSCs are often cultured in laboratory settings for purposes of ex vivo ex...
High dose methotrexate and extended hours high-flux hemodialysis for the treatment of primary central nervous system lymphoma in a patient with end stage renal disease [0.03%]
终末期肾病患者中枢神经系统淋巴瘤的高剂量甲氨蝶呤治疗及长时间高效透析清除
Howard Mutsando,Magid Fahim,Devinder S Gill et al.
Howard Mutsando et al.
This report discusses the case of a 52 year old female with post-transplant lymphoproliferative disorder, confined to the central nervous system, which was managed with high dose methotrexate (HDMTX) in the context of end stage renal diseas...
Katja Fiedler,Cornelia Brunner
Katja Fiedler
In recent years, the prospective isolation of hematopoietic stem and progenitor cells has identified the hierarchical structure of hematopoietic development and lineage-commitment. Moreover, these isolated cell populations allowed the eluci...
Platelet-derived growth factors and their receptors in normal and malignant hematopoiesis [0.03%]
血小板源性生长因子及其受体在正常和恶性造血作用中的作用
Jean-Baptiste Demoulin,Carmen P Montano-Almendras
Jean-Baptiste Demoulin
Platelet-derived growth factors (PDGF) bind to two closely related receptor tyrosine kinases, PDGF receptor α and β, which are encoded by the PDGFRA and PDGFRB genes. Aberrant activation of PDGF receptors occurs in myeloid malignancies as...
Yan Yu,Min Xie,Rui Kang et al.
Yan Yu et al.
High mobility group box 1 (HMGB1) is a nuclear DNA-binding protein, which functions as Damage Associated Molecular Pattern molecule (DAMP) when released from cells under conditions of stress, such as injury and infection. Recent studies ind...
Cancer-testis antigens: the current status on antigen regulation and potential clinical use [0.03%]
癌症睾丸抗原：抗原调节和潜在临床应用的现状
Seah H Lim,Yana Zhang,Jian Zhang
Seah H Lim
Immunotherapy is theoretically an attractive therapeutic option for patients with hematological malignancies. Various laboratory studies suggested the importance of the choice of tumor antigen for successful immunotherapy. Cancer-testis ant...
The association of hepatitis B virus infection with B-cell non-Hodgkin lymphoma - a review [0.03%]
乙型肝炎病毒感染与B细胞非霍奇金淋巴瘤相关性的研究进展综述
Fabrizio Marcucci,Enea Spada,Alfonso Mele et al.
Fabrizio Marcucci et al.
Epidemiological studies performed over the last decade have demonstrated a positive association between persistent, hepatitis B surface antigen (HBsAg)-positive hepatitis B virus (HBV) infection and B-cell non-Hodgkin lymphoma (NHL), with H...
Role of high-dose melphalan and autologous peripheral blood stem cell transplantation in AL amyloidosis [0.03%]
高剂量美法仑和自体外周血干细胞移植在AL型淀粉样变性疾病治疗中的作用
Vaishali Sanchorawala
Vaishali Sanchorawala
AL amyloidosis is the most common form of systemic amyloidosis and is associated with an underlying plasma cell dyscrasia. The disease is often difficult to recognize because of its broad range of manifestations and, what are often, vague s...
Matthew J Oberley,Deng-Shun Wang,David T Yang
Matthew J Oberley
The Vav family of proteins are guanine nucleotide exchange factors which have been shown to be deregulated in several types of human cancer. There are three members of the Vav family that have been identified which are members of the Dbl do...
C-MOPP: the forgotten regimen plus Rituximab for untreated and relapsed follicular lymphoma [0.03%]
未治疗和复发的滤泡性淋巴瘤的遗忘方案C-MOPP联合利妥昔单抗疗法
Mark J Fesler,Medhat Osman,James Glauber et al.
Mark J Fesler et al.
C-MOPP is a chemotherapy regimen for the treatment of Non-Hodgkin lymphoma (NHL). Because rituximab improves results in B-cell NHL, we added rituximab to C-MOPP, giving it the term C-MOPP-R. We retrospectively report the results of C-MOPP-R...