Aging- and activation-induced platelet microparticles suppress apoptosis in monocytic cells and differentially signal to proinflammatory mediator release [0.03%]
老年及活化诱导的血小板微颗粒在单核细胞凋亡中的抑制作用及其对促炎介质释放的差异化信号转导研究
Elena M Vasina,Sandra Cauwenberghs,Mareike Staudt et al.
Elena M Vasina et al.
Background: Platelet microparticles (PM) are the most abundant cell-derived microparticles in the blood, and accumulate in thrombo-inflammatory diseases. Platelets produce PM upon aging via an apoptosis-like process and b...
Understanding basic steps to hematopoietic stem cell transplantation evaluation [0.03%]
理解血髓干细胞移植评估的基本步骤
Melissa Logue,Bipin N Savani
Melissa Logue
We are celebrating one millionth transplant in year 2013! With continued improvement in hematopoietic cell transplantation (HCT) outcome, the indications for HCT continue to grow. Furthermore the sources of stem cells and the number of suit...
Patrick L Stevens,Nishitha M Reddy
Patrick L Stevens
Immune surveillance is a dynamic process that involves an intact immune system to identify and protect the host against tumor development. The increased understanding of the genetics, infections and hematological malignancies in congenital ...
Bruton's tyrosine kinase mediated signaling enhances leukemogenesis in a mouse model for chronic lymphocytic leukemia [0.03%]
布鲁顿酪氨酸激酶介导的信号传导可增强小鼠慢性淋巴细胞白血病模型中的白血病发生率
Laurens P Kil,Marjolein Jw de Bruijn,Jennifer Ac van Hulst et al.
Laurens P Kil et al.
In chronic lymphocytic leukemia (CLL) signals from the B cell receptor (BCR) play a major role in disease development and progression. In this light, new therapies that specifically target signaling molecules downstream of the BCR continue ...
Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemia [0.03%]
Ikaros作为B细胞急性淋巴细胞白血病肿瘤抑制因子的功能研究
Philippe Kastner,Arnaud Dupuis,Marie-Pierre Gaub et al.
Philippe Kastner et al.
The Ikaros transcription factor is crucial for many aspects of hematopoiesis. Loss of function mutations in IKZF1, the gene encoding Ikaros, have been implicated in adult and pediatric B cell acute lymphoblastic leukemia (B-ALL). These muta...
Suppression of STAT5A and STAT5B chronic myeloid leukemia cells via siRNA and antisense-oligonucleotide applications with the induction of apoptosis [0.03%]
STAT5A和STAT5B在siRNA及反义寡核苷酸应用于慢性髓系白血病细胞中的抑制作用及其促凋亡效应
Burçin Tezcanlı Kaymaz,Nur Selvi,Aysun Adan Gokbulut et al.
Burçin Tezcanlı Kaymaz et al.
Signal transducers and activators of transcription (STAT) proteins function in the JAK/STAT signaling pathway and are activated by phosphorylation. As a result of this signaling event, they affect many cellular processes including cell grow...
Repeated treatment with high dose cyclophosphamide for severe autoimmune diseases [0.03%]
大剂量环磷酰胺治疗自身免疫性疾病回顾
Amy E Dezern,Michael J Styler,Daniel B Drachman et al.
Amy E Dezern et al.
High dose cyclophosphamide (HiCY) without stem cell rescue has been shown to induce remissions in patients with severe autoimmune disorders (SADS). However, up to 80% of these patients ultimately relapse. Here we review the outcomes of seve...
Gene mutations and molecularly targeted therapies in acute myeloid leukemia [0.03%]
急性髓系白血病的基因突变和分子靶向治疗
Eleftheria Hatzimichael,Georgios Georgiou,Leonidas Benetatos et al.
Eleftheria Hatzimichael et al.
Acute myelogenous leukemia (AML) can progress quickly and without treatment can become fatal in a short period of time. However, over the last 30 years fine-tuning of therapeutics have increased the rates of remission and cure. Cytogenetics...
Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander? [0.03%]
慢性淋巴细胞白血病中的调节性T细胞：演员或无辜的旁观者？
Giovanni D&#x;Arena,Vittorio Simeon,Fiorella D&#x;Auria et al.
Giovanni D&#x;Arena et al.
Regulatory T (Treg) cells are now under extensive investigation in chronic lymphocytic leukemia (CLL). This small subset of T-cells has been, in fact, considered to be involved in the pathogenesis and progression of CLL. However, whether Tr...
Stefania Gorini,Lucia Gatta,Laura Pontecorvo et al.
Stefania Gorini et al.
Extracellular ATP (eATP) is the most abundant among extracellular nucleotides and is commonly considered as a classical danger signal, which stimulates immune responses in the presence of tissue injury. In fact, increased nucleotide concent...