Transfusion-independent β(0)-thalassemia after bone marrow transplantation failure: proposed involvement of high parental HbF and an epigenetic mechanism [0.03%]
输血独立型β(o)地中海贫血与骨髓移植失败后的高父母亲HbF及表观遗传机制的关联性报告
Katia Paciaroni,Guido Lucarelli,Fabrizio Martelli et al.
Katia Paciaroni et al.
Currently, bone marrow transplantation is the only curative treatment for β-thalassemia and sickle cell disease. In rare cases, sustained and full fetal hemoglobin production was observed in patients after failure of bone marrow transplant...
STAT5 N-domain deleted isoforms are naturally occurring hypomorphs partially rescued in hematopoiesis by transgenic Bcl-2 expression [0.03%]
Stat5 N端结构域缺失的异构体是造血过程中可被Bcl-2转基因表达部分挽救的低功能等位基因变异体
Zhengqi Wang,Geqiang Li,Kevin D Bunting
Zhengqi Wang
Signal transducer and activator of transcription 5 (STAT5) is a critical regulator of normal and leukemic lympho-myeloid development through activation downstream of early-acting cytokines, their receptors, and JAKs. Truncation of STAT5 can...
The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis [0.03%]
转录因子Miz-1对胚胎和应激诱导的红细胞生成是必需的，但对成体红细胞生成可有可无
Christian Kosan,Marissa Rashkovan,Julie Ross et al.
Christian Kosan et al.
Myc-interacting zinc finger protein 1 (Miz-1) is a BTB/POZ domain transcription factor that regulates complex processes such as proliferation and apoptosis. Constitutively Miz-1-deficient animals arrest embryonic development at E14.5 due to...
Ashraf Bakr,Youssef Al-Tonbary,Ghada Osman et al.
Ashraf Bakr et al.
The success that has been made in the care of patients with thalassemia has led to the emergence of unrecognized complications including several renal abnormalities. Chronic anemia and iron overload as well as the use of iron chelator are b...
Chronic myelogenous leukemia after postoperative adjuvant S-1 therapy for rectal cancer: a case report [0.03%]
术后卡培他滨辅助治疗后发生慢性粒细胞白血病一例报告
Masahiro Manabe,Takafumi Nishii,Junya Okita et al.
Masahiro Manabe et al.
We report a case in which chronic myelogenous leukemia (CML) developed after postoperative adjuvant S-1 therapy for rectal cancer. A 56-year-old man was diagnosed with rectal adenocarcinoma, which was treated with abdominoperineal resection...
Case Reports
American journal of blood research. 2013 Dec 18;3(4):286-9. DOI: 2013
N-cadherin impedes proliferation of the multiple myeloma cancer stem cells [0.03%]
N-钙黏着蛋白阻碍多发性骨髓瘤癌干细胞的增殖
Nicole M Sadler,Britney R Harris,Brittany A Metzger et al.
Nicole M Sadler et al.
Multiple myeloma (MM) is an incurable malignancy of the plasma cells localized to the bone marrow. A rare population of MM cancer stem cells (MM-CSCs) has been shown to be responsible for maintaining the pull of residual disease and to cont...
Asu Fergun Yilmaz,Guray Saydam,Fahri Sahin et al.
Asu Fergun Yilmaz et al.
Granulocytic sarcoma also called myeloid sarcoma is an extramedullary tumor of immature granulocytic cells. It is a rare entity, and mostly accompanied by acute myeloid leukemia. It is observed during the course of myeloproliferative disord...
Romiplostim for delayed platelet recovery and secondary thrombocytopenia following allogeneic stem cell transplantation [0.03%]
Romiplostim治疗allo-HSCT后血小板恢复延迟和继发性血小板减少症的疗效及安全性：一项随机、双盲、安慰剂对照Ⅱ期研究
Limei Michelle Poon,Antonio Di Stasi,Uday Popat et al.
Limei Michelle Poon et al.
Delayed recovery of platelet count post allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been associated with worse transplant outcomes. Thrombopoietic agents have been successfully used in immune mediated thrombocytopenia...
Carlo Lucioni,Carlo Finelli,Silvio Mazzi et al.
Carlo Lucioni et al.
Myelodysplastic syndromes (MDS) encompass a range of myeloid neoplasms characterised by a defect in haematopoietic stem cell maturation, resulting in peripheral cytopenias. As a major consequence, most MDS patients become anaemic, so as to ...
Detection of immune suppressive neutrophils in peripheral blood samples of cancer patients [0.03%]
检测癌症患者外周血中免疫抑制性中性粒细胞
Suyang Hao,Mary Andersen,Hongbo Yu
Suyang Hao
Neutrophils provide first-line defense against infections and are potent effectors in innate and adaptive immunity. Recently neutrophils have been shown to play important roles in multiple antitumor reactions. A subset of mature neutrophils...