Multidisciplinary clinical management of paroxysmal nocturnal hemoglobinuria [0.03%]
阵发性夜间血红蛋白尿的多学科临床管理策略
Fahri Sahin,Melda Comert Ozkan,Nihal Gokmen Mete et al.
Fahri Sahin et al.
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease caused by clonal expansion of one or more hematopoietic stem cell (HSC) lines due to a somatic mutation of the phosphatidylinositol glycan anchor (PIG-A) gene located on ...
Concomitant use of radiotherapy and two topoisomerase inhibitors to treat adult T-cell leukemia with a radiotherapy-resistant bulky disease: a case series [0.03%]
两种拓扑异构酶抑制剂与放疗联合治疗成人T细胞白血病-淋巴瘤肿块型难治性病灶：3例报告
Kosuke Obama
Kosuke Obama
Concomitant chemoradiotherapy is established as the standard treatment to improve the prognosis of several types of solid tumor, but has not been the general practice for hematological malignancies. Here, I report two cases of adult T-cell ...
Case Reports
American journal of blood research. 2014 Dec 15;4(2):106-9. DOI: 2014
Imported visceral leishmaniasis - unexpected bone marrow diagnosis in a patient with fever, pancytopenia, and splenomegaly [0.03%]
进口内脏利什曼病一一发热、全血细胞减少和脾大的患者的意外骨髓诊断结果
Valentina Gallina,Raffaella Binazzi,Arber Golemi et al.
Valentina Gallina et al.
Leishmaniasis is spreading from mediterranean countries to the north of Europe. The Alps are not an endemic region and there are only few reports of sporadic cases. We report the case of a 72 year old male who presented after a syncope with...
Case Reports
American journal of blood research. 2014 Dec 15;4(2):101-5. DOI: 2014
Long-lasting complete response to imatinib in a patient with systemic mastocytosis exhibiting wild type KIT [0.03%]
KIT基因野生型系统性肥大细胞增多症患者接受伊马替尼治疗后持续完全缓解的病例报告
Peter Valent,Sabine Cerny-Reiterer,Gregor Hoermann et al.
Peter Valent et al.
Systemic mastocytosis (SM) is a hematopoietic disorder characterized by abnormal expansion of mast cells (MCs) in visceral organs. The skin is involved in most cases. In adult patients the transforming KIT mutation D816V is usually present ...
Comparative of three methods (ELIZA, MAIPA and flow cytometry) to determine anti-platelet antibody in children with ITP [0.03%]
三种方法（ELIZA、MAIPA和流式细胞仪）检测ITP儿童血小板抗体的比较研究
Mohsen Hamidpour,Ghader Khalili,Nader Tajic et al.
Mohsen Hamidpour et al.
Immune (idiopathic) thrombocytopenic purpurea (ITP) is an autoimmune disease characterized by the increased anti-platelet antibodies in the patient's sera and decreased platelets in the blood circulation. This study has determined and chara...
Dkk-1 and IL-7 in plasma of patients with multiple myeloma prevent differentiation of mesenchymal stem cells into osteoblasts [0.03%]
华氏巨球蛋白血症患者血浆中的Dkk-1和IL-7可阻止间充质干细胞向成骨细胞分化
Brittany A Nierste,Carlotta A Glackin,Julia Kirshner
Brittany A Nierste
Bone disease is the leading cause of morbidity associated with multiple myeloma (MM). Lytic bone lesions have been detected in 90% of patients diagnosed with MM and present a great therapeutic challenge. After the removal of the tumor burde...
The role of glucocorticoid receptor (GR) polymorphisms in human erythropoiesis [0.03%]
糖皮质激素受体(GR)多态性在人类红细胞生成中的作用
Lilian Varricchio,Anna Rita Migliaccio
Lilian Varricchio
Glucocorticoids are endogenous steroid hormones that regulate several biological functions including proliferation, differentiation and apoptosis in numerous cell types in response to stress. Synthetic glucocorticoids, such as dexamethasone...
Towards an off-the-shelf vaccine therapy targeting shared B-cell tumor idiotypes [0.03%]
针对共享B细胞肿瘤特异型的现成型疫苗疗法的研究进展
Flavio E Baio,Larry W Kwak,Jinsheng Weng
Flavio E Baio
The ideal tumor antigen is one expressed selectively by the tumor, present in all cancer patients, essential for tumor survival and nonetheless able to induce both humoral and cellular immune response. The personalized idiotype (Id) of the ...
Concomitant a novel ALAS2 mutation and GATA1 mutation in a newborn: a case report and review of the literature [0.03%]
ALAS2和GATA1基因双突变合存在所致先天性再生障碍性贫血1例报告及文献复习
Bhavya S Doshi,Carlos Abramowsky,Michael Briones et al.
Bhavya S Doshi et al.
GATA-1, an X-linked gene, encodes a transcription factor that plays a role in erythropoiesis and megakaryopoiesis. GATA-1 mutations have been associated with various diseases, such as X-linked thrombocytopenia. ALAS2 is an X-linked erythroi...
Case Reports
American journal of blood research. 2014 Sep 5;4(1):41-5. DOI: 2014
Multiplex amplification refractory mutation system (MARMS) for the detection of β-globin gene mutations among the transfusion-dependent β-thalassemia Malay patients in Kelantan, Northeast of Peninsular Malaysia [0.03%]
马来西亚半岛东北Kelatan省输血依赖型β-地中海贫血患者中β-珠蛋白基因突变的多重等位基因特异性PCR检测方法研究
Sarifah Hanafi,Rosline Hassan,Rosnah Bahar et al.
Sarifah Hanafi et al.
The aim of this study was to adapt MARMS with some modifications to detect beta mutation in our cohort of thalassemia patients. We focused only on transfusion-dependent thalassemia Malay patients, the predominant ethnic group (95%) in the K...