Comparative transcriptomics and gene expression divergence associated with homoploid hybrid speciation in Argyranthemum [0.03%]
同源多倍体物种形成中的比较转录组和基因表达分歧——以Argyranthemum属植物为例
Oliver W White,Alfredo Reyes-Betancort,Mark A Carine et al.
Oliver W White et al.
Ecological isolation is increasingly thought to play an important role in speciation, especially for the origin and reproductive isolation of homoploid hybrid species. However, the extent to which divergent and/or transgressive gene express...
Chromosome-level reference genomes of two imperiled desert fishes: spikedace (Meda fulgida) and loach minnow (Tiaroga cobitis) [0.03%]
两种濒危沙漠鱼类的染色体水平参考基因组：刺柄鱼（Meda fulgida）和小沙鱼（Tiaroga cobitis）
Nicolas M Alexandre,Alexander C Cameron,David Tian et al.
Nicolas M Alexandre et al.
North American minnows (Cypriniformes: Leuciscidae) comprise a diverse taxonomic group, but many members, particularly those inhabiting deserts, face elevated extinction risks. Despite conservation concerns, leuciscids remain under sampled ...
Identification of an ADAMTS2 frameshift variant in a cat family with Ehlers-Danlos syndrome [0.03%]
猫家族埃勒斯-丹洛斯综合征ADAMTS2移码变异的鉴定
Rebecca Simon,Sarah Kiener,Nina Thom et al.
Rebecca Simon et al.
We investigated 4 European domestic shorthair kittens with skin lesions consistent with the dermatosparaxis type of the Ehlers-Danlos syndrome, a connective tissue disorder. The kittens were sired by the same tomcat but were born by 3 diffe...
Demonstration of in vivo engineered tandem duplications of varying sizes using CRISPR and recombinases in Drosophila melanogaster [0.03%]
利用CRISPR和重组酶在果蝇中体内构建不同长度的串联重复序列
David W Loehlin,Georgia L McClain,Manting Xu et al.
David W Loehlin et al.
Tandem gene duplicates are important parts of eukaryotic genome structure, yet the phenotypic effects of new tandem duplications are not well-understood, in part owing to a lack of techniques to build and modify them. We introduce a method,...
An approach for prioritizing candidate genes from RNA-seq using preclinical cocaine self-administration datasets as a test case [0.03%]
一种利用临床前可卡因自给数据集的RNA测序候选基因优先排序的方法
Annika Vannan,Michela Dell&#x;Orco,Nora I Perrone-Bizzozero et al.
Annika Vannan et al.
RNA-sequencing (RNA-seq) technology has led to a surge of neuroscience research using animal models to probe the complex molecular mechanisms underlying brain function and behavior, including substance use disorders. However, findings from ...
Systematic profiling of subtelomeric silencing factors in budding yeast [0.03%]
系统研究芽殖酵母亚端粒沉默因子的作用机制
Alejandro Juárez-Reyes,J Abraham Avelar-Rivas,Jhonatan A Hernandez-Valdes et al.
Alejandro Juárez-Reyes et al.
Subtelomeric gene silencing is the negative transcriptional regulation of genes located close to telomeres. This phenomenon occurs in a variety of eukaryotes with salient physiological implications, such as cell adherence, virulence, immune...
Rong Zhang,Huaxuan Wu,Yasai Li et al.
Rong Zhang et al.
Linkage disequilibrium (LD) analysis is fundamental to the investigation of the genetic architecture of complex traits (e.g. human disease, animal and plant breeding) and population structure and evolution dynamics. However, until now, stud...
Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures [0.03%]
复杂性状和候选基因：多种遗传结构下的基因型变异估算
Mitchell J Feldmann,Giovanny Covarrubias-Pazaran,Hans-Peter Piepho
Mitchell J Feldmann
Large-effect loci-those statistically significant loci discovered by genome-wide association studies or linkage mapping-associated with key traits segregate amidst a background of minor, often undetectable, genetic effects in wild and domes...
Strain variation in gene expression impact of hyphal cyclin Hgc1 in Candida albicans [0.03%]
白色念珠菌中菌丝细胞周期素HGC1的表达受菌株变异的影响
Anupam Sharma,Aaron P Mitchell
Anupam Sharma
Formation of hyphae is a key virulence trait of the fungal pathogen Candida albicans. Hypha morphogenesis depends upon the cyclin Hgc1, which acts together with cyclin-dependent protein kinase Cdc28 to phosphorylate effectors that drive pol...