Model Organism Modifier (MOM): a user-friendly Galaxy workflow to detect modifiers from genome sequencing data using Caenorhabditis elegans [0.03%]
模型生物调控因子(MOM)：一种基于果蝇的用户友好的Galaxy工作流程用于使用基因组测序数据检测调控因子
Tatiana Maroilley,K M Tahsin Hassan Rahit,Afiya Razia Chida et al.
Tatiana Maroilley et al.
Genetic modifiers are variants modulating phenotypic outcomes of a primary detrimental variant. They contribute to rare diseases phenotypic variability, but their identification is challenging. Genetic screening with model organisms is a wi...
Probing the physiological role of the plastid outer-envelope membrane using the oemiR plasmid collection [0.03%]
利用oemiR质粒集合探究叶绿体外膜的生理作用
Serena Schwenkert,Wing Tung Lo,Beata Szulc et al.
Serena Schwenkert et al.
Plastids are the site of complex biochemical pathways, most prominently photosynthesis. The organelle evolved through endosymbiosis with a cyanobacterium, which is exemplified by the outer envelope membrane that harbors more than 40 protein...
Identification of a spontaneously arising variant affecting thermotaxis behavior in a recombinant inbred Caenorhabditis elegans line [0.03%]
在重组近交秀丽隐杆线虫品系中鉴定影响趋热行为的自发突变体
Jihye Yeon,Charmi Porwal,Patrick T McGrath et al.
Jihye Yeon et al.
Analyses of the contributions of genetic variants in wild strains to phenotypic differences have led to a more complete description of the pathways underlying cellular functions. Causal loci are typically identified via interbreeding of str...
Near chromosome-level genome assembly of the microsporidium Hamiltosporidium tvaerminnensis [0.03%]
近染色体水平的微孢子虫Hamiltosporidium tvaerminnensis基因组组装图谱
Pascal Angst,Jean-François Pombert,Dieter Ebert et al.
Pascal Angst et al.
Microsporidia are intracellular parasitic fungi whose genomes rank among the smallest of all known eukaryotes. A number of outstanding questions remain concerning the evolution of their large-scale variation in genome architecture, responsi...
A multiplexed plant-animal SNP array for selective breeding and species conservation applications [0.03%]
一种用于选择育种和物种保护的植物-动物SNP微阵列
Sara Montanari,Cecilia Deng,Emily Koot et al.
Sara Montanari et al.
Reliable and high-throughput genotyping platforms are of immense importance for identifying and dissecting genomic regions controlling important phenotypes, supporting selection processes in breeding programs, and managing wild populations ...
An expanded GCaMP reporter toolkit for functional imaging in Caenorhabditis elegans [0.03%]
用于秀丽隐杆线虫功能成像的扩展GCaMP报告基因工具包
Jimmy Ding,Lucinda Peng,Sihoon Moon et al.
Jimmy Ding et al.
In living organisms, changes in calcium flux are integral to many different cellular functions and are especially critical for the activity of neurons and myocytes. Genetically encoded calcium indicators (GECIs) have been popular tools for ...
Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases [0.03%]
利用罕见疾病遗传模型开展罕见病研究（GENETICS及G3系列报道）
Philip Hieter,Brenda Andrews,Douglas Fowler et al.
Philip Hieter et al.
De novo genome assembly and comparative genomics for the colonial ascidian Botrylloides violaceus [0.03%]
新型基因组组装和比较基因组学在紫囊纤细亚口动物中的应用
Jack T Sumner,Cassidy L Andrasz,Christine A Johnson et al.
Jack T Sumner et al.
Ascidians have the potential to reveal fundamental biological insights related to coloniality, regeneration, immune function, and the evolution of these traits. This study implements a hybrid assembly technique to produce a genome assembly ...
Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus) [0.03%]
非洲脊鼠(Acomys cahirinus)染色体水平基因组组装报告
Elizabeth Dong Nguyen,Vahid Nikoonejad Fard,Bernard Y Kim et al.
Elizabeth Dong Nguyen et al.
There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference...
Phenotypic defects from the expression of wild-type and pathogenic TATA-binding proteins in new Drosophila models of Spinocerebellar Ataxia Type 17 [0.03%]
新的果蝇模型中的野生型和致病型TATA结合蛋白表达的表型缺陷：I型脊小脑共济失调Spinocerebellar Ataxia Type 17)
Nikhil Patel,Nadir Alam,Kozeta Libohova et al.
Nikhil Patel et al.
Spinocerebellar Ataxia Type 17 (SCA17) is the most recently identified member of the polyglutamine (polyQ) family of disorders, resulting from abnormal CAG/CAA expansion in the TATA box-binding protein (TBP), an initiation factor essential ...