Characterization of novel recombinant mycobacteriophages derived from homologous recombination between two temperate phages [0.03%]
源于两个温和噬菌体同源重组的新型结核分枝杆菌噬菌体特征分析
Hamidu T Mohammed,Catherine Mageeney,Jamie Korenberg et al.
Hamidu T Mohammed et al.
Comparative analyses of mycobacteriophage genomes reveals extensive genetic diversity in genome organization and gene content, contributing to widespread mosaicism. We previously reported that the prophage of mycobacteriophage Butters (clus...
Cardiac muscle-restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features [0.03%]
心脏肌肉限制性部分丢失Nos1ap的表达对心电图特征的影响有限但显著
Alexa Smith,Dallas Auer,Morgan Johnson et al.
Alexa Smith et al.
Genome-wide association studies have identified sequence polymorphisms in a functional enhancer of the NOS1AP gene as the most common genetic regulator of QT interval and human cardiac NOS1AP gene expression in the general population. Funct...
A haplotype-resolved chromosome-scale genome for Quercus rubra L. provides insights into the genetics of adaptive traits for red oak species [0.03%]
染色体水平的红橡树基因组为适应性状遗传解析提供新见解
Beant Kapoor,Jerry Jenkins,Jeremy Schmutz et al.
Beant Kapoor et al.
Northern red oak (Quercus rubra L.) is an ecologically and economically important forest tree native to North America. We present a chromosome-scale genome of Q. rubra generated by the combination of PacBio sequences and chromatin conformat...
Conserving a threatened North American walnut: a chromosome-scale reference genome for butternut (Juglans cinerea) [0.03%]
美国 walnut 植物基因组研究取得重要进展
Cristopher R Guzman-Torres,Emily Trybulec,Hannah LeVasseur et al.
Cristopher R Guzman-Torres et al.
With the advent of affordable and more accurate third-generation sequencing technologies, and the associated bioinformatic tools, it is now possible to sequence, assemble, and annotate more species of conservation concern than ever before. ...
A comparative analysis of stably expressed genes across diverse angiosperms exposes flexibility in underlying promoter architecture [0.03%]
对不同被子植物中稳定表达的基因进行比较分析，揭示了其上游调控元件结构的灵活性
Eric J Y Yang,Cassandra J Maranas,Jennifer L Nemhauser
Eric J Y Yang
Promoters regulate both the amplitude and pattern of gene expression-key factors needed for optimization of many synthetic biology applications. Previous work in Arabidopsis found that promoters that contain a TATA-box element tend to be ex...
Peter Z Schall,Paige A Winkler,Simon M Petersen-Jones et al.
Peter Z Schall et al.
Recent advances in long-read sequencing have enabled the creation of reference-quality genome assemblies for multiple individuals within a species. In particular, 8 long-read genome assemblies have recently been published for the canine mod...
Demographic reconstruction of the Western sheep expansion from whole-genome sequences [0.03%]
全基因组序列解析西部绵羊的群体扩张历史
Pedro Morell Miranda,André E R Soares,Torsten Günther
Pedro Morell Miranda
As one of the earliest livestock, sheep (Ovis aries) were domesticated in the Fertile Crescent about 12,000-10,000 years ago and have a nearly worldwide distribution today. Most of our knowledge about the timing of their expansions stems fr...
Lysines K117 and K147 play conserved roles in Ras activation from Drosophila to mammals [0.03%]
从果蝇到哺乳动物赖氨酸K117和K147在Ras激活中的保守作用
Jiya Singh,Prashath Karunaraj,Max Luf et al.
Jiya Singh et al.
Ras signaling plays an important role in growth, proliferation, and developmental patterning. Maintaining appropriate levels of Ras signaling is important to establish patterning in development and to prevent diseases such as cancer in matu...
Near-complete de novo assembly of Tricholoma bakamatsutake chromosomes revealed the structural divergence and differentiation of Tricholoma genomes [0.03%]
染色体从头几乎完整组装揭示了口蘑属基因组的结构分化及多样性
Hiroyuki Ichida,Hitoshi Murata,Shin Hatakeyama et al.
Hiroyuki Ichida et al.
Tricholoma bakamatsutake, which is an edible ectomycorrhizal fungus associated with Fagaceae trees, may have diverged before the other species in Tricholoma section Caligata. We generated a highly contiguous whole-genome sequence for T. bak...
Nanopore-based direct sequencing of RNA transcripts with 10 different modified nucleotides reveals gaps in existing technology [0.03%]
基于纳米孔直接测序具有10种不同修饰核苷酸的RNA转录本发现现有技术中的缺陷
Joshua T Burdick,Annelise Comai,Alan Bruzel et al.
Joshua T Burdick et al.
RNA undergoes complex posttranscriptional processing including chemical modifications of the nucleotides. The resultant-modified nucleotides are an integral part of RNA sequences that must be considered in studying the biology of RNA and in...