A gap-free, telomere-to-telomere genome assembly for the Caenorhabditis briggsae reference strain AF16 [0.03%]
一种无间隙端到端基因组组装结果，用于参考菌株AF16的布拉氏构巢酵母基因组序列參考菌株AF16的缺口-free且端对端的线性基因組 assemblies
Lance M O&#x;Connor,Nicolas D Moya,Nikita S Jhaveri et al.
Lance M O&#x;Connor et al.
The nematode Caenorhabditis elegans was the first metazoan to have its genome completely sequenced and assembled. Since that time, researchers have continuously updated the reference genome and manually curated its approximately 20,000 gene...
Alternative Lengthening of Telomeres is dependent on RAD52 and RAD51 gene function in the budding yeast Naumovozyma castellii [0.03%]
端粒替代延长依赖于棒状大芽抱酵母中的RAD52和RAD51基因功能
Humberto Itriago,Marita Cohn
Humberto Itriago
Telomerase is a specialized ribonucleoprotein enzyme responsible for elongation of telomeres, the DNA ends of eukaryotic chromosomes. In the absence of telomerase activity, telomeres progressively shorten, eventually triggering a DNA damage...
Helitrons are enriched in lichenized fungi with long generation lengths and small distribution sizes [0.03%]
Helitron元件在世代周期长且分布范围小的地衣型真菌中富集
Julianna Paulsen,Stephen T Sharrett,Devin Mumey et al.
Julianna Paulsen et al.
Transposable elements (TEs) have the potential to drive genome evolution by introducing mutations and causing structural instability and chromosomal rearrangements, particularly under conditions like environmental or genetic stress. In this...
Integrin-Talin axis regulates mechanosensory presynaptic development and behavioral habituation to mechanical stimulation [0.03%]
整合素-突连蛋白轴调控机械感受性突触前发生及对机械刺激的习惯化行为
Jonathan Amezquita,Nelson A Ayala,Muriel Desbois et al.
Jonathan Amezquita et al.
From invertebrates to mammals, integrin signaling plays important roles in neuron development. β-Integrins are regulated by binding ECM, and through intracellular activation or inside-out signaling via Talin and Kindlin. While Integrins ar...
Measuring the change in deleterious mutation burden of barley germplasm conserved over one regeneration cycle [0.03%]
大麦种质经一次繁殖周期后有害变异负担的变化检测
Yong-Bi Fu
Yong-Bi Fu
Deleterious mutations will occur and accumulate in germplasm conserved under long-term cold storage. However, little is known about the extent of deleterious mutation accumulation in conserved germplasm. This study represents an attempt to ...
BiTUGA: scalable prevalence-based unitig association testing for binary traits [0.03%]
基于频率的二分性状单元体关联检测方法BiTUGA：可扩展的基于单元体频率的二元性状关联分析
Jannes Mittelbach,Birgit Kersten,Stefan Kurtz
Jannes Mittelbach
Sequence-based association studies can be challenging in large and highly repetitive genomes. While reference-free k-mer approaches enable direct analysis of sequence variation from sequencing reads, current tools often rely on constructing...
Improved chromosome-level genome assembly of Pleurotus ostreatus CCMSSC 00389 [0.03%]
模式草菇基因组的改进染色体水平组装
Yanjiao Ma,Chenyang Huang,Mengran Zhao et al.
Yanjiao Ma et al.
Pleurotus ostreatus is one of the major cultivated edible mushrooms in China, and possesses high nutritional value and prominent medicinal properties. A chromosome-level genome assembly of this species is therefore of great significance for...
Multi-locus Models of Deleterious Epimutation-Selection Balance and the Evolution of Recombination Modifiers [0.03%]
多基因位点的有害表观突变-选择平衡模型及重组调控因子的进化 модели遗传有害表观突变-选择平衡和重组修饰因子的进化
Gregory Chernomas,Cortland K Griswold
Gregory Chernomas
Epigenetic inheritance has the potential to act as an additional source of phenotypic variation in natural populations of organisms. Previous theoretical works have investigated the deleterious potential of epigenetic variation at single lo...