A pcyt-1 Allelic Series Reveals In Vivo Consequences of Reduced Phosphatidylcholine Synthesis in C. elegans [0.03%]
一种PCYT-1等位基因系列揭示了C. elegans中磷脂酰胆碱合成减少的体内后果
August Qvist,Delaney Kaper,Marcus Henricsson et al.
August Qvist et al.
Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes and is synthesized in part via the rate-limiting enzyme PCYT1A. In humans, hypomorphic PCYT1A variants cause diverse disorders. To define how graded reductio...
Copy Number Variation: A Substrate for Plant Adaptation and Stress Response in Arabidopsis [0.03%]
拷贝数变异——拟南芥适应及应对压力的载体
Piyal Karunarathne,Yannick Schäfer,Anna Glushkevich et al.
Piyal Karunarathne et al.
Copy number variation (CNV) is a major source of genomic diversity that shapes gene family evolution and may contribute to ecological differentiation, yet its genome-wide ecological relevance remains poorly understood. Here, we analyzed CNV...
CYClones: A highly powered, fully genotyped, 8-parent yeast mapping population [0.03%]
CYClones：一种高通量、完整基因分型的酿酒酵母八亲本重组群体
Gareth A Cromie,Russell S Lo,Trey S Morgan et al.
Gareth A Cromie et al.
The budding yeast Saccharomyces cerevisiae is a remarkably adaptable organism that thrives in diverse environments. Global sequencing of natural isolates has revealed extensive genetic diversity within the species. Here, we describe the con...
Dissecting genetic variance structure and evaluating genomic prediction models for single-cross hybrids derived from Stiff Stalk and Non-Stiff Stalk maize heterotic groups [0.03%]
基于遗传方差结构剖析淀粉 stalk 和非 stiff stalk 玉米杂种优势群衍生的单交种及其基因组预测模型评估
Jenifer Camila Godoy Dos Santos,Jode Edwards,Elizabeth Lee et al.
Jenifer Camila Godoy Dos Santos et al.
The early 20th-century discovery of heterosis and the establishment of heterotic groups transformed maize (Zea mays L.) into a keystone of global agriculture. However, maize breeding faces two significant challenges: the gradual decline of ...
Long read, high-coverage reference genome of the Nymphalid butterfly Catonephele acontius (Nymphalidae: Biblidinae) [0.03%]
长读取、高覆盖率的凤蝶科纸板蝶(Catonephele acontius)参考基因组
Marcus Hicks,Tan Nhat Pham,Océane Seudre et al.
Marcus Hicks et al.
Background: Catonephele acontius (Nymphalidae:Biblidinae:Epicalinii) is a butterfly species with a wide distribution across the Neotropics including the Amazon. Here, we present a long-read high-coverage reference genome ...
Genomes of the ex-type strains of Elsinoë mangiferae and E. perseae, the causal agents of scab on mango and avocado [0.03%]
杧果和牛油果煤烟病病原真菌Elsinoë mangiferae 和 E. perseae 的基因组序列
Priscila Chaverri,Efraín Escudero-Leyva,Pepijn W Kooij et al.
Priscila Chaverri et al.
Elsinoë species are slow-growing, hemibiotrophic to necrotrophic fungi that cause scab diseases on economically important fruit crops. Genome resources for many host-specific species remain limited. We report high-quality draft genome asse...
Duplication-based genetic dissection of the Down syndrome critical region reveals its complex functional organization [0.03%]
基于复制的遗传方法解剖21三体综合征关键区并揭示其复杂的功能组织形式
Xiaoling Jiang,Chunhong Liu,Zhuo Xing et al.
Xiaoling Jiang et al.
Down syndrome (DS), associated with trisomy 21, is the most common genetic cause of developmental delay and intellectual disability, yet the specific dosage-sensitive genes and the associated genetic mechanisms underlying these phenotypes r...
The complete sequence of the silkworm W chromosome uncovers its rapid evolution by large-scale duplications/deletions and translocation of W-linked genes [0.03%]
家蚕W染色体完整序列揭示其通过大片段重复/缺失及重组的快速演化机制
Wanshun Li,Hiroaki Abe,Yue Chen et al.
Wanshun Li et al.
The complete sequence of the W chromosome which carries feminization activity in the silkworm is crucial for understanding the sex-determination system in Lepidoptera. However, extensive accumulation of transposons due to lack of recombinat...
Revisiting the genome assembly of Lupinus species reveals differential diploidization after a shared whole-genome duplication [0.03%]
重建羽扇豆属植物基因组装配揭示了共享全基因组复制后的不同二倍体化现象
Liying Yang,Yanju Shuai,Weiran Li et al.
Liying Yang et al.
Accurate genome assemblies are essential for comparative genomics, yet Hi-C-guided scaffolding can introduce structural errors that misrepresent chromosome architecture and bias evolutionary inferences. Here, we identified pervasive scaffol...
Deconstructing empirical fitness seascapes across scales of granularity [0.03%]
基于精细度量的实证适应性 seascape 的层次结构分析
Swathi Nachiar Manivannan,C Brandon Ogbunugafor
Swathi Nachiar Manivannan
The fitness landscape metaphor remains resonant in evolutionary theory and has facilitated the birth of newer concepts, like the fitness seascape, that consider the role of environmental context in shaping the dynamics of evolution. Since i...