Simulating the impact of recombination rate on genomic selection breeding outcomes [0.03%]
重组率对基因组选择育种效果影响的模拟研究
Zsa Zsa Boyny,Nicholas Lester,Karen Massel et al.
Zsa Zsa Boyny et al.
Recombination shuffles alleles during meiosis, driving genetic diversity and shaping the outcomes of breeding programs. By breaking the physical links between loci, recombination facilitates the creation of new allelic combinations that can...
Recombination and the role of pseudo-overdominance in polyploid evolution [0.03%]
重组在多倍体进化中的作用及假准显性的作用
William W Booker,Daniel R Schrider
William W Booker
Natural selection is an imperfect force that can under some conditions fail to prevent the buildup of deleterious mutations. Small population sizes and the lack of recombination are two such scenarios that reduce the efficiency of selection...
A systematic overexpression screen identifies cytotoxic genes encoded by the Cluster L1 mycobacteriophage LeBron [0.03%]
系统性过表达筛选鉴定了由Cluster L1分支棒状杆菌噬菌体LeBron编码的细胞毒性基因
Earick J Cagang,Brian Nguyen,Elizabeth Paul et al.
Earick J Cagang et al.
Bacteriophages represent a vast reservoir of genetic diversity however, functional annotation remains a major challenge, as most predicted gene products lack detectable similarity to characterized gene families. Experimental approaches such...
Hepatocyte-targeted Bap1 reduction in the liver primes an inflammatory transcriptional response [0.03%]
BAP1肝细胞特异性敲低诱导肝脏炎症反应
William C Nenad,Peyton C Kuhlers,Ian R Sturgill et al.
William C Nenad et al.
BRCA1-associated protein 1 (BAP1) is a deubiquitinase, frequently altered in cancers including hepatocellular carcinoma and cholangiocarcinoma. While Bap1 has been shown to play key roles in metabolism, maintenance of tissue homeostasis, an...
Back to the future 2: the implications of germplasm structure on the balance between short and long-term genetic gain in a changing target population of environments [0.03%]
展望未来第二部：育种目标动态变化下遗传进展的短期与长期平衡及其对核心种质构成的影响
Frank Technow,Dean Podlich,Mark Cooper
Frank Technow
Plant breeding operates within a complex genetic landscape determined by genes interacting within biological networks and with the environment. This environment is not constant but subject to short-term fluctuations and long-term shifts. Th...
pSB3, a member of the 2-micron family of plasmids, replicates and is efficiently partitioned in multiple budding yeast species [0.03%]
新型酿酒酵母质粒pSB3的复制和分配研究
Anastasiia Mereshchuk,Joyce S K Chew,Melanie J Dobson
Anastasiia Mereshchuk
The plasmids pSB3 of Zygosaccharomyces rouxii and the 2-micron circle of Saccharomyces cerevisiae belong to a small family of multi-copy yeast DNA plasmids. Members are similarly organized, with each encoding a conserved version of Flp, the...
Upper bound on the mutational burden imposed by a CRISPR-Cas9 gene-drive element [0.03%]
CRISPR-Cas9基因驱动元件施加的突变负担上限估算
Michael S Overton,Sean E Guy,Xingsen Chen et al.
Michael S Overton et al.
Homing-based CRISPR-Cas9 gene drives (CCGDs) are powerful tools for genetic control of wild populations, with applications from disease eradication to species conservation. However, Cas9 alone and in a complex with guide RNA can cause doubl...
Reference genome assemblies for the North American bumble bees Bombus flavifrons and Bombus fervidus, two phenotypically polymorphic species from distinct phylogenetic lineages [0.03%]
北美大黄蜂和炽热大黄蜂的参考基因组组装：两个来自不同谱系的表型多态物种
Jeffrey D Lozier,Rena M Schweizer,Sheina B Sim et al.
Jeffrey D Lozier et al.
We present genome assemblies for two bumble bee (Hymenoptera: Apidae: Bombus) species: Bombus (Pyrobombus) flavifrons and Bombus (Thoracobombus) fervidus. These species are widespread pollinators across North America and both exhibit intras...
Comparative analysis of draper mutant alleles and RNAi expression systems in the ovary and brain of Drosophila melanogaster [0.03%]
模式节肢动物生殖系和脑中排水基因的突变及RNA干扰敲低分析
Guangmei Liu,Pamela Yang,Trung Le et al.
Guangmei Liu et al.
The phagocytic receptor Draper (Drpr) mediates clearance of apoptotic cells in Drosophila melanogaster, yet how distinct drpr alleles and RNAi constructs differ in efficiency and phenotypic outcomes has not been systematically compared. Her...
Metabolic state modulates risky foraging behavior via multiple branches of the insulin/IGF-1-like pathway in C. elegans [0.03%]
代谢状态通过胰岛素/IGF-1样通路的多个分支调节秀丽隐杆线虫的风险取食行为
Kaiden H Price,Jason T Braco,Sofia Franco et al.
Kaiden H Price et al.
Foraging to acquire nutrients is an essential and sometimes risky behavior displayed by nearly all animals. Appropriately balancing foraging risks with nutrient requirements is pivotal for peak survival and reproduction, and metabolic state...