RNA sequencing in adult Drosophila females identifies estrogen-related receptor-dependent transcriptional changes in metabolism, DNA replication, and translation [0.03%]
RNA测序分析揭示了成年雌性果蝇中的ERR依赖性代谢、DNA复制及翻译的转录变化
Sophie A Fleck,Eleanor B Goldstone,Lesley N Weaver
Sophie A Fleck
Nuclear receptors, transcription factors essential for organism growth, development, and reproduction, are expressed in a variety of tissues, with some exhibiting differential expression between males and females. The estrogen-related recep...
Proteome analyses reveal endoplasmic reticulum stress-induced changes in protein abundance associated with Ube2j2 deficiency in human cell culture [0.03%]
蛋白质组分析揭示了Ube2j2缺陷诱导的人类细胞系内质网压力下蛋白丰度的变化
Caroline L Dahlberg,Matthew Zinkgraf,Sophie Heiden Laugesen et al.
Caroline L Dahlberg et al.
The unfolded protein response (UPR) helps reinstate cellular proteostasis upon an accumulation of misfolded proteins in the endoplasmic reticulum (ER), in part through ER-associated degradation (ERAD). Ube2j2 is an ER-localized E2 ubiquitin...
Sweetalana,Shirin Nataneli,Shengmiao Huang et al.
Sweetalana et al.
Runs of homozygosity (ROH) are genomic regions that arise when identical haplotypes are inherited from a shared ancestor. In this study, we explored ROH across 556 whole-genome sequences from domesticated and non-domesticated dogs. Then, we...
Rare variant analysis of whole genome sequenced juvenile idiopathic arthritis multiplex pedigrees identifies rare variants in NOD2 and ACVR1 [0.03%]
全基因组序列多系谱分析鉴别出幼年特发性关节炎中的罕见NOD2和ACVR1变异体
Cecile N Avery,Edgar J Hernandez,Sandy G Kazuko et al.
Cecile N Avery et al.
Juvenile idiopathic arthritis (JIA) is a complex rheumatic disease that is influenced by environmental and genetic factors. Linkage studies and genome-wide association studies have identified genes that contribute to the risk of developing ...
Scalable medium-density genotyping platforms for cultivar identification, pedigree authentication, marker-assisted and genomic selection, and other applications in strawberry [0.03%]
草莓品种鉴定、血缘验证、标记辅助和基因组选择及其他应用的可扩展中密度基因分型平台
Dominique D A Pincot,Joshua A Sleper,Randi A Famula et al.
Dominique D A Pincot et al.
A broad spectrum of high-density genotyping approaches, including single nucleotide polymorphism (SNP) arrays, genotyping-by-sequencing, and whole-genome reduced-representation sequencing, have been shown to perform well in strawberry (Frag...
A Translocation within the Ogataea Species Complex Alters Local Subtelomeric Chromatin while Maintaining Overall Genome Organization [0.03%]
огатаеа物种复合体内的易位改变了局部着丝粒端侧染色质，但保持了整体基因组组织结构
Tiffany J Lundberg,Nickolas M Lande,Daniel Tourevski et al.
Tiffany J Lundberg et al.
Eukaryotic genomic DNA is packaged in the nucleus as chromatin - a DNA-protein aggregate regulating genome function, including transcription. Chromatin is classified as either active euchromatin or silent heterochromatin, with each marked b...
A marine-derived fungal genome of Annulohypoxylon annulatoides reveals AT-rich isochores with putative regulatory functions [0.03%]
孔孢壳属菌种基因组富含AT的异染色质区具有潜在调控功能
Che-Yu Thiat-Ut Kuo,Yu-Ching Liu,Cheng-Ju Yang et al.
Che-Yu Thiat-Ut Kuo et al.
Marine and coastal fungi experience intense environmental variability, yet the genomic features associated with tolerance to such conditions remain unclear. From 56 fungal isolates collected along the Lailai rocky shore in northern Taiwan, ...
Caroline West,Lauren Dineen,Abigail Leavitt LaBella
Caroline West
Transfer RNAs (tRNAs) are known for delivering amino acids to the growing polypeptide chain during translation. They can also influence gene expression, especially in times of nutrient starvation, through differential tRNA expression and mo...
Protein secretion routes in fungi are predicted by the length of the hydrophobic helix in the signal sequence [0.03%]
通过信号肽中疏水螺旋的长度预测真菌中的蛋白质分泌途径
Tristan Sones-Dykes,Edward W J Wallace
Tristan Sones-Dykes
Secreted proteins are translocated across membranes through multiple routes. In eukaryotes, secreted proteins with N-terminal signal sequences can use either the signal recognition particle and its receptor or the alternative Sec complex to...