Accurate Genomic Predictions for Chronic Wasting Disease in North American Elk [0.03%]
北美麋鹿慢性消耗病的精准基因组预测
Christopher M Seabury,Eric K Bhattarai,Marcel Brun et al.
Christopher M Seabury et al.
The geographic expansion of chronic wasting disease (CWD) in North American elk (Cervus canadensis) has not been well-mitigated by traditional best management practices, diagnostic surveillance, and depopulation of positive herds. Using a c...
Chromosome-level reference genome for the common wall gecko (Tarentola mauritanica) enables comparative and functional studies in geckos [0.03%]
用于壁虎（Tarentola mauritanica）的染色体水平参考基因组可实现壁虎的比较和功能研究
Gabriel Mochales-Riaño,Valéria Marques,Miguel A Carretero et al.
Gabriel Mochales-Riaño et al.
Reptiles exhibit remarkable ecological and physiological diversity, yet genomic resources for this group remain relatively scarce, limiting research on adaptation, evolution, and invasion biology. The common wall gecko, Tarentola mauritanic...
Autoregulation of three yeast ribosomal protein genes by splicing inhibition [0.03%]
通过抑制剪接自动调节三个酵母核糖体蛋白基因
David Granas,Anirudh Kesanapally,Michael A White et al.
David Granas et al.
Yeast ribosomal protein genes RPL18B, RPL28 and RPS22B are autoregulated by inhibition of splicing. This is demonstrated by inserting their introns into a chromosomal copy of GFP and observing repression upon induction of the cognate protei...
LocusPackRat: An R Package to Support Prioritizing Candidate Genes from Large GWAS Intervals with Standardized Evidence Aggregation [0.03%]
LocusPackRat：一个支持候选基因优先排序的R包，用于从大型全基因组关联研究间隔中以标准方式聚合证据
Brian Gural,Todd Kimball,Anh N Luu et al.
Brian Gural et al.
Genome-wide association studies (GWAS) routinely implicate broad loci that span tens of megabases and contain dozens of genes, making the leap from locus to causal gene challenging, especially in model organism cohorts with reduced mapping ...
APOBEC3A is the predominant global editor of cytosines in human mRNAs and in single-strand RNA viruses [0.03%]
APOBEC3A是人类mRNA和单链RNA病毒中胞苷的主要编辑酶
Zachary W Kockler,Hamed Bostan,Leszek J Klimczak et al.
Zachary W Kockler et al.
APOBEC cytidine deaminases can convert cytosines to uracils in DNA as well as in RNA. The knowledge of DNA deamination motifs preferred by individual APOBECs revealed APOBEC3A as a major source of hypermutation in cancer. However, the exten...
Genetic analyses enabled by the Fourth Chromosome Resource Projectreveal unexpected mutant phenotypes and suggest new disease models [0.03%]
第四号染色体资源项目计划助力基因分析发现意外突变表型并提出新的疾病模型
Bonnie M Weasner,Michael J Stinchfield,Brandon P Weasner et al.
Bonnie M Weasner et al.
To date the Fourth Chromosome Resource Project (FCRP) has deposited over 850 stocks for the genetic analysis of its 79 protein coding genes. Here we employ those stocks to reveal unexpected phenotypes for multiple exemplar genes. Expression...
Cheng-Hung Tsai,Jason E Stajich
Cheng-Hung Tsai
Phyling is a fast, scalable, and user-friendly tool supporting phylogenomic reconstruction of species phylogenies directly from protein-encoded genomic data. It identifies orthologous genes by searching protein sequences against a curated s...
Distinct D-box Motifs in SPD-2 Mediate APC/CFZR-1-Dependent Degradation and Centrosomal Localization in Caenorhabditis elegans Embryos [0.03%]
秀丽杆线虫胚胎中不同的D盒基序介导SPD-2的APC/C-FZL-1依赖性降解和中心体定位
Rachel N Yim,Joseph R DiPanni,Paollette A Rivera et al.
Rachel N Yim et al.
Centrosome duplication must be tightly regulated to maintain genomic stability. In Caenorhabditis elegans, the APC/C and co-activator FZR-1 function as negative regulators of centrosome duplication by targeting specific substrates for prote...
Integrative linkage mapping and transcriptomic profiling uncover ozone-response modules in a peri-urban forest tree [0.03%]
整合连锁图谱和转录组分析揭示了近郊树木中臭氧响应模块
Xochitl Granados-Aguilar,Verónica Reyes-Galindo,Gustavo I Giles-Pérez et al.
Xochitl Granados-Aguilar et al.
The genus Abies Mill. (Pinaceae) comprises a group of conifers distributed across boreal and temperate regions, including eight species with disjunct distributions across Mexico's highest mountain chains. Abies religiosa (Kunth) Schltdl. & ...