Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish [0.03%]
Gli3R介导的Hh信号抑制可改变斑马鱼胚胎转录组
Anna J Moyer,Summer B Thyme
Anna J Moyer
Hedgehog signaling is a conserved developmental pathway that patterns diverse tissues during vertebrate embryogenesis. In zebrafish, disruptions to the hedgehog pathway cause well-characterized defects in specific cell types including neuro...
CX-5461 and Doxorubicin activate a shared DNA damage-associated transcriptional response in human cardiomyocytes [0.03%]
CX-5461和多柔比星在人类心肌细胞中激活了共享的DNA损伤相关转录反应
Sayan Paul,José A Gutiérrez,Alyssa R Bogar et al.
Sayan Paul et al.
CX-5461 (CX) is under investigation for the treatment of late-stage cancers. While CX was first described as an RNA polymerase I inhibitor, it has recently been shown to primarily inhibit the beta isoform of topoisomerase II. This isoform i...
Strength of selection potentiates distinct adaptive responses in an evolution experiment with outcrossing yeast [0.03%]
强选择有利于芽殖酵母进化实验中不同的适应性反应
Mark A Phillips,Megan Sandoval-Powers,Rupinderjit K Briar et al.
Mark A Phillips et al.
Selection intensity is expected to influence the magnitude and genetic architecture of adaptive responses, yet it is rarely evaluated as a standalone variable in experimental evolution studies. Here, we evolved outcrossing populations of Sa...
Noc1 downregulation induces nucleolar stress and upregulates p53 isoforms, with a robust increase of the truncated p53E isoform in Drosophila wing discs [0.03%]
Noc1下调在果蝇翅盘中诱导核仁应激并上调p53异构体，尤其是截短型p53E异构体的强增加现象
Andrea Vutera Cuda,Shivani Bajaj,Valeria Manara et al.
Andrea Vutera Cuda et al.
Disruption of ribosome biogenesis triggers nucleolar stress, a conserved cellular response that activates p53. We previously demonstrated that depletion of Nucleolar Complex Protein 1 (Noc1) in Drosophila wing imaginal discs impairs rRNA ma...
High-quality genome assembly and linkage map for a rapidly evolving plant species: Silene uniflora [0.03%]
高质量的基因组组装和连锁图谱用于快速进化的植物物种：Silene uniflora
Owen G Osborne,Daniel P Wood,Mariya P Dobreva et al.
Owen G Osborne et al.
The genus Silene is an important model system for fields as diverse as sex chromosome evolution, speciation and disease ecology. However, genomic resources remain scarce in the genus. Here, we present a near chromosome-scale genome assembly...
Deep-mutational scanning libraries using tiled-region exchange mutagenesis [0.03%]
利用分段区域交换诱变构建深突变扫描文库
Kortni Kindree,Claire A Chochinov,Keerath Bhachu et al.
Kortni Kindree et al.
The analysis of gene function frequently requires the generation of mutants. Deep-mutational scanning (DMS) has emerged as a powerful tool to decipher important functional residues within genes and proteins. However, methods for performing ...
Genetics of retroactive measures of stress response in pigs before and after exposure to a disease challenge [0.03%]
疾病挑战暴露的猪应激反应回溯性措施的遗传研究
Fazhir Kayondo,Hayder Al-Shanoon,Yolande M Seddon et al.
Fazhir Kayondo et al.
This study explored the genetics of cortisol (CL), cortisone (CN), DHEA (DH), and DHEA-S (DS) in hair of 610 pigs that was grown while they were exposed to infectious stressors (IS) from a natural polymicrobial disease challenge. Results we...
A draft genome assembly of the agricultural pest Leucoptera coffeella and analysis of its dsRNA processing machinery is a key step towards RNAi-based biopesticides in Lepidoptera [0.03%]
农业害虫Leucoptera coffeella的基因组草图及Lepidoptera中基于RNAi的生物农药的关键步骤：其dsRNA加工装置的分析
Jay K Goldberg,Leonardo A Vidal,Erick S L Queiroz et al.
Jay K Goldberg et al.
The Coffee Leaf Miner (Lepidoptera: Lyonetiidae: Leucoptera coffeella) is a specialist herbivore and major global pest of coffee plants. Current pest control strategies primarily rely on chemical pesticides which in turn negatively impact b...
Transcriptome- and phenotype-based epistasis analysis in Caenorhabditis elegans reveals daf-16/FoxO-dependent and independent effects of daf-2/InsR in L1 starvation and recovery [0.03%]
基于线虫转录组和表型的上位性分析揭示了daf-2/InsR在L1饥饿与复苏中通过daf-16/FoxO依赖或非依赖效应发挥作用
Kinsey Fisher,Rojin Chitrakar,L Ryan Baugh
Kinsey Fisher
Reduced insulin/IGF signaling (IIS) in Caenorhabditis elegans increases starvation resistance in a daf-16/FoxO-dependent fashion, but it is unclear whether the effects of reduced IIS are entirely dependent on daf-16/FoxO. We used RNA sequen...
Whole-genome sequences of the dwarf honey bee subgenus Micrapis: Apis andreniformis and Apis florea [0.03%]
dwarf 意大利蜂亚属 Micrapis 的全基因组序列：Apis andreniformis 和 Apis florea
Atma Ivancevic,Madison Sankovitz,Holly Allen et al.
Atma Ivancevic et al.
The Micrapis subgenus, which includes the black dwarf honey bee (Apis andreniformis) and the red dwarf honey bee (Apis florea), remains underrepresented in genomic studies despite its ecological significance. Here, we present high-quality d...