Researchers have discovered that black splotches on brown bullhead catfish in lakes in New England and Canada are likely caused by a transmissible cancer, the first one found in fish. The discovery raises questions about the cancer's origin...
Follicular Lymphoma Transformation is Characterized by Cytokine-associated Remodeling of Stromal and Macrophage Compartments [0.03%]
滤泡性淋巴瘤转化的特点是细胞因子相关基质和巨噬细胞区室的重塑
Nicholas J Haradhvala,Stephanie Pei Tung Yiu,Laura Beckmann et al.
Nicholas J Haradhvala et al.
Across cancer, one of the most frequent examples of histologic transformation is the evolution of follicular lymphoma (FL) to an aggressive large cell lymphoma. Despite recent progress, understanding of the molecular and cellular underpinni...
Editor's Note: Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness [0.03%]
编者按：胆碱能信号通过毒蕈碱受体直接和间接抑制胰腺肿瘤发生及癌干细胞特性
Bernhard W Renz,Takayuki Tanaka,Masaki Sunagawa et al.
Bernhard W Renz et al.
Published Erratum
Cancer discovery. 2026 Aug 3;16(8):1711. DOI:10.1158/2159-8290.CD-26-1218 2026
Eline J M Bertrums,Ruben van Boxtel
Eline J M Bertrums
Brady and colleagues investigated the mutational consequences of cancer treatment on the genomes of 160 childhood cancer survivors who developed a subsequent neoplasm (SN). Their research aids in directing the next steps toward the preventi...
René Bernards
René Bernards
Ever since immune checkpoint blockade showed activity in the treatment of cancer, the search has been on for combination regimens that make this therapy more effective. In this issue, Blagg and colleagues describe an unorthodox approach to ...
Xiuning Le,Jürgen Wolf
Xiuning Le
Beyond established rare fusions, such as ALK and ROS1, emerging ultrarare fusions involving receptor tyrosine kinases or their ligands, including EGFR-SHC1, further guide us to uncover novel mechanisms of oncogenic activation and correspond...
Researchers have found that some lung tumors in mice can cause cachexia by directly communicating with neurons to alter eating behavior. Further, researchers showed that efforts to reduce cachexia through feeding the mice a high-fat diet pa...
Diane Yang,Stefan Andrew Harry,Harrison Byron Chong et al.
Diane Yang et al.
Small molecules that modulate protein complexes have transformed cell biology and oncology, yet few chemical starting points exist to probe protein-protein interactions. To expand this space, we developed molecular COUPLrs, elaborated small...
Nearly 11 years after T-VEC became the first oncolytic virus approved in a major market, the closest candidate to follow it-Replimune's RP1, now facing an FDA advisory committee-remains a locally injected herpesvirus for melanoma, underscor...
Timothy Yap, MBBS, PhD, vice president and head of clinical development in the Therapeutics Discovery Division and professor in the Department of Investigational Cancer Therapeutics (Phase I Program) at The University of Texas MD Anderson C...