HIF-2-dependent Regulation of PTHrP and Paraneoplastic Hypercalcemia in Aggressive Clear Cell Renal Cell Carcinoma [0.03%]
缺氧诱导因子-2调节甲状旁腺激素相关蛋白及侵袭性透明细胞肾癌的副肿瘤性高钙血症
Arijit Mal,Bingqing Xie,Zane Gray et al.
Arijit Mal et al.
Renal cell carcinoma (RCC) patients with hypercalcemia (HC) have worse outcomes. HC often involves PTHrP, and the role of HIF-2 is incompletely understood. Leveraging RCC tumorgraft (TG) models of HC, which were characterized by tumor cell ...
Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression [0.03%]
筛选靶向肿瘤微管的药物鉴定PKC调节剂可作为多靶点抑制胶质母细胞瘤进展的药物
Daniel D Azorín,Dirk C Hoffmann,Nils R Hebach et al.
Daniel D Azorín et al.
Glioblastomas are incurable primary brain tumors that depend on neural-like cellular processes, tumor microtubes (TMs), to invade the brain. TMs also interconnect single tumor cells to a communicating multicellular network that resists curr...
Association between Medicaid Expansion and 5-Year Survival among Individuals Diagnosed with Cancer [0.03%]
医疗补助计划的扩大与癌症患者五年生存率之间的关系
Elizabeth J Schafer,Christopher J Johnson,Fabio Y Moraes et al.
Elizabeth J Schafer et al.
Medicaid expansion is associated with improvements in access to early detection and treatment services, and 2-year overall survival (OS) among individuals with cancer. However, the association with improvements in longer-term survival remai...
Recurrent immunogenic neoantigens and their cognate T-cell receptors in treatment-resistant metastatic prostate cancer [0.03%]
治疗抵抗性转移性前列腺癌中的复发性免疫原性新抗元及其相应的T细胞受体
Nofar Gumpert,Shira Sagie,Claudia Arnedo-Pac et al.
Nofar Gumpert et al.
New approaches that generate long-lasting therapeutic responses in therapy-resistant metastatic cancer patients are urgently needed. To address this challenge, we developed SpotNeoMet, a novel data-driven pipeline that systematically identi...
Correction: Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers [0.03%]
关于RAS激活抑制剂RMC-6236在驱动型癌症中转化研究和治疗评价的更正通知
Jingjing Jiang,Lingyan Jiang,Benjamin J Maldonato et al.
Jingjing Jiang et al.
Published Erratum
Cancer discovery. 2025 Oct 6;15(10):2186. DOI:10.1158/2159-8290.CD-25-1519 2025
Correction: INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors [0.03%]
订正：选择性CDK2抑制剂INX-315可诱导实体肿瘤细胞周期停滞和衰老
Catherine Dietrich,Alec Trub,Antonio Ahn et al.
Catherine Dietrich et al.
Published Erratum
Cancer discovery. 2025 Oct 6;15(10):2185. DOI:10.1158/2159-8290.CD-25-1502 2025
Emmanuel E Korsah,Noah A Dusseau,Eunhee Yi
Emmanuel E Korsah
Extrachromosomal DNA (ecDNA) has been suggested as a key factor of tumor heterogeneity at the genomic and transcriptional levels, via unequal segregation and ecDNA hub formation, respectively. In this issue of Cancer Discovery, two studies ...
Boosting Sensitivity through a Multianalyte Cerebrospinal Fluid Approach for Diagnosis, Prognostication, and Immune Monitoring for Brain Tumors [0.03%]
基于脑脊液的多指标方法提高中枢神经系统肿瘤诊断、预后和免疫监测灵敏度
Hannah K Weiss,Camila S Fang,Daniel A Orringer et al.
Hannah K Weiss et al.
The CSF-BAM assay, developed by Pearlman, Wang, and colleagues, integrates the detection of somatic mutations, genome aneuploidy, and B- and T-cell receptor clonality from a single cerebrospinal fluid DNA library to increase the sensitivity...
Epigenetic and transcriptional programs define osteosarcoma subtypes and establish targetable vulnerabilities [0.03%]
表观遗传和转录谱式定义骨肉瘤亚型并确定可作用的肿瘤脆弱性
Eunice Lopez-Fuentes,Andrew S Clugston,Alex G Lee et al.
Eunice Lopez-Fuentes et al.
Osteosarcoma is a genomically complex tumor characterized by widespread structural rearrangements. This complexity has limited development of therapeutic strategies informed by molecular mechanisms of oncogenesis. We hypothesized that epige...
Epigenetic regulation of chromosomal instability by EZH2 methyltransferase [0.03%]
EZH2甲基转移酶通过表观遗传调控染色体不稳定性
Yang Bai,Albert S Agustinus,Shira Yomtoubian et al.
Yang Bai et al.
Chromosomal instability (CIN) and epigenetic reprogramming are central drivers of breast cancer progression, yet the mechanisms connecting them remain elusive. We uncover a direct role of EZH2 histone methyltransferase in promoting CIN in t...