Functional neuroimaging of fatty acid amide hydrolase inhibition in posttraumatic stress disorder: a randomized clinical trial [0.03%]
脂肪酸氨酶抑制功能神经影像学在创伤后应激障碍中的应用：一项随机临床试验
Ryann Tansey,Irene Perini,Gavin N Petrie et al.
Ryann Tansey et al.
The endocannabinoid ligand anandamide (AEA) plays a role in fear extinction, the conceptual foundation of the gold standard treatment for posttraumatic stress disorder (PTSD), exposure-based psychotherapy. Converging evidence from animal mo...
Sex and dose-dependent effects of cannabidiol on cocaine consumption in mice [0.03%]
大麻素对小鼠可卡因消耗的剂量和性别依赖性效应
Veronika Llerena,Iva Tic,Maria Llach-Folcrà et al.
Veronika Llerena et al.
Cocaine use disorder (CUD) is a neuropsychiatric disorder marked by compulsive drug-seeking and loss of control over cocaine intake, with women experiencing a faster addictive development and greater adverse outcomes despite lower incidence...
Postpartum Psychosis: could genetic vulnerability to insomnia or short sleep duration be protective? [0.03%]
产后精神病：失眠或睡眠时间短的遗传易感性可能是保护性的吗？
Chiara Petrosellini,Sofia H Eriksson,Nicholas Meyer et al.
Chiara Petrosellini et al.
Postpartum Psychosis (PP) is a severe and understudied perinatal mental illness which disproportionately affects women with bipolar disorder (BD). A relationship between sleep disturbance and PP is often assumed, but is poorly understood. F...
Natural Anti-NMDAR1 autoantibodies associate with slowed decline of cognitive functions in Alzheimer's diseases [0.03%]
天然抗NMDAR1自身抗体与阿尔茨海默病认知功能减退放缓相关性研究
Xianjin Zhou
Xianjin Zhou
Low titers of blood circulating natural anti-NMDAR1 autoantibodies were reported in ~10% of the general human population. Their potential effects on NMDAR functions in the brain, however, remain unknown. We developed a new method to more ac...
SARS-CoV-2 infection during pregnancy and neurodevelopmental outcomes in early childhood [0.03%]
孕期新冠病毒感染及儿童早期神经发育结局的关系研究
Lisa A Croen,Yinge Qian,Luke Grosvenor et al.
Lisa A Croen et al.
SARS-CoV-2 infection in pregnancy has become common, yet very little is known about the impact of prenatal exposure on child development. Our objective was to examine the impact of infection with SARS-CoV-2 during pregnancy on child neurode...
Identifying drug targets for schizophrenia through gene prioritization [0.03%]
通过基因优先排序识别治疗精神分裂症的药物靶点
Julia Kraft,Alice Braun,Swapnil Awasthi et al.
Julia Kraft et al.
Schizophrenia genome-wide association studies (GWASes) have identified >250 significant loci and prioritized >100 disease-related genes. However, gene prioritization efforts have mostly been restricted to locus-based methods that ignore inf...
Several novel classes of small regulatory RNAs show widespread changes in schizophrenia and bipolar disorder and extensive linkages to critical brain processes [0.03%]
几类小型调控RNA在精神分裂症和双相情感障碍中广泛变化并与关键大脑过程密切相关
Stepan Nersisyan,Phillipe Loher,Iliza Nazeraj et al.
Stepan Nersisyan et al.
Transcriptomic studies of post-mortem brain samples in schizophrenia (SCZ) and bipolar disorder (BD) have primarily focused on messenger RNAs (mRNAs) but have given limited attention to small non-coding RNAs (sncRNAs). In this study, we pre...
Trajectory of depression occurrence before, during, and after dementia diagnosis: A population-based study [0.03%]
一项基于人口的纵向研究：痴呆诊断前后的抑郁症发病轨迹
Wenzhe Yang,Weiwei Li,Sakura Sakakibara et al.
Wenzhe Yang et al.
Depression and dementia commonly co-occur, yet little is known about depression trajectories across dementia stages. We aimed to map depression occurrence before, during, and after dementia diagnosis, and to identify factors associated with...
Minocycline attenuates panicogenic responses in a CO2-induced panic attack model: a translational approach [0.03%]
多西环素通过二氧化碳诱发的恐慌模型中的惊恐反应：一种转化方法
Beatriz F G de Oliveira,Laiana A Quagliato,Alana T Frias et al.
Beatriz F G de Oliveira et al.
There is a connection between neuroinflammation and panic attacks (PA), as microglia-driven pro-inflammatory responses help detect homeostatic disturbances like CO₂ inhalation. This model has become widely used in research since CO₂ expos...
Echoes of childhood trauma: the relationship between adverse childhood experiences, brain structure, and mental health in aging adults [0.03%]
童年创伤的余波：不利童年经历、大脑结构和老年人心理健康之间的关系
Anne Klimesch,Leonie Ascone,Götz Thomalla et al.
Anne Klimesch et al.
Adverse childhood experiences (ACEs) are associated with persistent mental health risks and brain structural differences across adulthood, yet their long-term neurobiological relevance in aging populations remains unclear. Given that ACEs a...